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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共9条记录   CCR1 as a target for multiple myeloma [作者：Vallet, S; Anderson, KC,期刊：Expert Opinion on Therapeutic Targets, 页码：1037-1047 , 文章类型： Review，,卷期：2011年15-9] Introduction: By directing cell trafficking, differentiation and growth, chemokines modulate the immune response and are involved in the pathogenesis of autoimmune diseases and cancers, including multiple myeloma (MM). M... Refined fructose and cancer [作者：Liu, HB; Heaney, AP,期刊：Expert Opinion on Therapeutic Targets, 页码：1049-1059 , 文章类型： Review，,卷期：2011年15-9] Introduction: Caloric excess, including increased refined carbohydrate intake, is associated with higher cancer risk emphasizing the importance of improved understanding of cancer cell metabolism in tumor survival and me... Ceramide formation as a target in beta-cell survival and function [作者：Lang, F; Ullrich, S; Gulbins, E,期刊：Expert Opinion on Therapeutic Targets, 页码：1061-1071 , 文章类型： Review，,卷期：2011年15-9] Introduction: Ceramide may be synthesized de novo or generated by sphingomyelinase-dependent hydrolysis of sphingomyelin. Areas covered: The role of ceramide, ceramide-sensitive signaling and ion channels in beta-cell ap... Wnt-signaling pathways in progressive renal fibrosis [作者：Nelson, PJ; von Toerne, C; Grone, HJ,期刊：Expert Opinion on Therapeutic Targets, 页码：1073-1083 , 文章类型： Review，,卷期：2011年15-9] Introduction: The prevention and potential reversal of interstitial fibrosis is a central strategy for the treatment of progressive renal disease. This strategy requires a better understanding of the underlying pathophys... Nuclear receptors as therapeutic targets for Alzheimer's disease [作者：Mandrekar-Colucci, S; Landreth, GE,期刊：Expert Opinion on Therapeutic Targets, 页码：1085-1097 , 文章类型： Review，,卷期：2011年15-9] Introduction: Alzheimer's disease (AD) is characterized by the accumulation and extensive deposition of amyloid beta (A beta) in the parenchyma of the brain. This accumulation of amyloid is associated with perturbations ... The mTOR protein as a target in thyroid cancer [作者：de Souza, ECL; Ferreira, ACF; de Carvalho, DP,期刊：Expert Opinion on Therapeutic Targets, 页码：1099-1112 , 文章类型： Review，,卷期：2011年15-9] Introduction: The mammalian target of rapamycin (mTOR) protein is a downstream effector of the phosphatidilinositol-3 kinase (PI3K)/Akt pathway, which regulates not only cell proliferation and viability, but also iodide ... Osteopontin: a potentially important therapeutic target in cancer [作者：Ahmed, M; Behera, R; Chakraborty, G; Jain, S; Kumar, V; Sharma, P; Bulbule, A; Kale, S; Kumar, S; Mishra, R; Raja, R; Saraswati, S; Kaur, R; Soundararajan, G; Kumar, D; Thorat, D; Sanyal, M; Ramdasi, A; Ghosh, P; Kundu, GC,期刊：Expert Opinion on Therapeutic Targets, 页码：1113-1126 , 文章类型： Review，,卷期：2011年15-9] Introduction: Cancer is an extremely complex disease and most cancer treatments are limited to chemotherapy, radiation and surgery. The progression of tumours towards malignancy requires the interaction of various cytoki... The role of inflammation in the pathogenesis of lung cancer [作者：Cho, WCS; Kwan, CK; Yau, S; So, PPF; Poon, PCM; Au, JSK,期刊：Expert Opinion on Therapeutic Targets, 页码：1127-1137 , 文章类型： Review，,卷期：2011年15-9] Introduction: It is reported that cancer may arise in chronically inflamed tissue. There is mounting evidence suggesting that the connection between inflammation and lung cancer is not coincidental but may indeed be caus... CX3CR1 as a target for airways inflammation [作者：Doggrell, SA,期刊：Expert Opinion on Therapeutic Targets, 页码：1139-1142 , 文章类型： Article，,卷期：2011年15-9] Inflammation is a key component of asthma. Membrane-bound chemokine CX3CL1 is markedly induced on endothelial cells by inflammatory cytokines, and CX3CL1 levels are elevated in the bronchoalveolar lavage (BAL) of subject...