- Synthesis of 2-aryl-4-(benzimidazol-2-yl)-1,2-dihydro[1,2,4]triazino[4,5-a]benzimidazol-1-one derivatives with preferential cytotoxicity against carcinoma cell lines
[作者:Styskala, J; Styskalova, L; Slouka, J; Hajduch, M,期刊:European Journal of Medicinal Chemistry, 页码:449-455 , 文章类型: Article,,卷期:2008年43-3]
In this paper we describe the preparation of some derivatives of 1,2,4-triazino[4,5-a]benzimidazol-1-ones (5 and 6), containing additional benzimidazole ring. These compounds were prepared using coupling reactions of ...
- Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs
[作者:Abraham, MH; Ibrahim, A; Acree, WE,期刊:European Journal of Medicinal Chemistry, 页码:478-485 , 文章类型: Article,,卷期:2008年43-3]
Values of in vitro gas to lung partition coefficients, K-lung, of VOCs have been collected from the literature. For 44 VOCs, application of the Abraham solvation equation to log K-lung yielded a correlation with R-2 =...
- Evaluation of myorelaxant activity of 7-substituted hexahydroquinoline derivatives in isolated rabbit gastric fundus
[作者:Gunduz, MG; Ozturk, GS; Vural, IM; Simsek, R; Sarioglu, Y; Safak, C,期刊:European Journal of Medicinal Chemistry, 页码:562-568 , 文章类型: Article,,卷期:2008年43-3]
In this article, 16 new methyl(ethyl) 4-(dichlorophenyl)-2,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates and methyl(ethyl) 2-methyl-4-(dichlorophenyl)-5-oxo-7-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-c...
- Bioactivity of novel transition metal complexes of N '-[(4-methoxy)thiobenzoyl]benzoic acid hydrazide
[作者:Shrivastav, A; Tripathi, P; Srivastava, AK; Singh, NK; Sharma, RK,期刊:European Journal of Medicinal Chemistry, 页码:577-583 , 文章类型: Article,,卷期:2008年43-3]
Cu(II), Fe(III), and Mn(II) complexes of a novel ligand N '-[(4-methoxy)thiobenzoyl]benzoic acid hydrazide (H(2)mtbh) have been synthesized and characterized by elemental analyses, IR, UV-vis, NMR, mass, EPR and Mossb...
- 1,8-Naphthyridines VI. Synthesis and anti-inflammatory activity of 5-(alkylamino)-N.N-diethyl[1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamides with a new substitution pattern on the triazole ring
[作者:Di Braccio, M; Grossi, G; Roma, G; Piras, D; Mattioli, F; Gosmar, M,期刊:European Journal of Medicinal Chemistry, 页码:584-594 , 文章类型: Article,,卷期:2008年43-3]
On the basis of the good anti-inflammatory properties shown by the 9-alkyl-N,N-dialkyl-5-(alkylamino)[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides 1, a series of analogues of such compounds, in which the 9-a...
- Synthesis, antifungal activity and CoMFA analysis of novel l,2,4-triazolo[1,5-a]pyrimidine derivatives
[作者:Chen, Q; Zhu, XL; Jiang, LL; Liu, ZM; Yang, GF,期刊:European Journal of Medicinal Chemistry, 页码:595-603 , 文章类型: Article,,卷期:2008年43-3]
In order to search novel agrochemicals with higher antifungal activity, a series of new 1,2,4-triazolo[1,5-a]pyrimidine derivatives bearing 1,3,4-oxadiazole moieties were designed and synthesized. Their antifungal act...
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