- Synthesis and biological activity of some new benzoxazoles
[作者:Temiz-Arpaci, O; Yildiz, I; Ozkan, S; Kaynak, F; Aki-Sener, E; Yalcin, I,期刊:European Journal of Medicinal Chemistry, 页码:1423-1431 , 文章类型: Article,,卷期:2008年43-7]
The synthesis and antimicrobial activity of a new series of 5-ethylsulphonyl-2-(substituted-phenyl/substituted-benzyl and/or phenylethyl)benzoxazole derivatives (3a-3t) except 3a, 3g, 3h, 3k [R.S. Pottorf, N.K. Chadha...
- Synthesis and anti-inflammatory activity evaluation of unsymmetrical selenides
[作者:Martinez-Ramos, F; Salgado-Zamora, H; Campos-Aldrete, ME; Melendez-Camargo, E; Marquez-Flores, Y; Soriano-Garcia, M,期刊:European Journal of Medicinal Chemistry, 页码:1432-1437 , 文章类型: Article,,卷期:2008年43-7]
The alkylation reaction of 2,2'-diseleno and 4,4'-diseleno-bis(benzoic acid) derivatives in the presence of sodium borohydride and alkyl halides allowed the synthesis of various new o- and p-alkylselenenylated benzoic...
- Synthesis and anticancer activity of lipophilic platinum(II) complexes of 3,5-diisopropylsalicylate
[作者:Yu, Y; Lou, LG; Liu, WP; Zhu, HJ; Ye, QS; Chen, XZ; Gao, WG; Hou, SQ,期刊:European Journal of Medicinal Chemistry, 页码:1438-1443 , 文章类型: Article,,卷期:2008年43-7]
Novel lipophilic platinum(II) complexes (LSPt-1-3). containing 3,5-diisopropylsalicylate (DIPS) as a leaving group and 2NH(3) or 1R,2R-diaminocyclohexane or (4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane as th...
- Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: Synthesis, biological evaluation and molecular modeling studies
[作者:Logee, C; Testard, A; Thieery, V; Lozach, O; Blairvacq, M; Robert, JM; Meijer, L; Besson, T,期刊:European Journal of Medicinal Chemistry, 页码:1469-1477 , 文章类型: Article,,卷期:2008年43-7]
Continuous efforts in microwave-assisted synthesis and the structure-activity relationships' (SARs) studies of novel modified 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitriles, allowed identification of new amidine and...
- Synthesis and in vitro biological evaluation of valine-containing prodrugs derived from clinically used HIV-protease inhibitors
[作者:Roche, D; Greiner, J; Aubertin, AM; Vierling, P,期刊:European Journal of Medicinal Chemistry, 页码:1506-1518 , 文章类型: Article,,卷期:2008年43-7]
In an approach to improve the pharmacological properties and pharmacokinetic profiles of the current protease inhibitors (PIs) used in clinics, and consequently, their therapeutic potential, we performed the synthesis...
- Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor
[作者:Song, EY; Kaur, N; Park, MY; Jin, Y; Lee, K; Kim, G; Lee, KY; Yang, JS; Shin, JH; Nam, KY; No, KT; Han, G,期刊:European Journal of Medicinal Chemistry, 页码:1519-1524 , 文章类型: Article,,卷期:2008年43-7]
A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among th...
- Structure-activity relationships of sandalwood odorants: Total synthesis and fragrance properties of cyclopropano-beta-santalol
[作者:Stappen, I; Hofinghoff, J; Friedl, S; Pammer, C; Wolschann, P; Buchbauer, G,期刊:European Journal of Medicinal Chemistry, 页码:1525-1529 , 文章类型: Article,,卷期:2008年43-7]
The synthesis and odor properties of cyclopropano-beta-santalol, a new santalol analogue, are described. The exocyclic double bond of the original molecule, beta-santalol, is replaced by a cyclopropane ring. Despite t...
- Synthesis, characterization, antifungal and anti-HIV activities of metal(II) complexes of 4,6-di-tert-butyl-3-[(2-hydroxyethyl)thio] benzene-1,2-diol
[作者:Loginova, NV; Koval'chuk, TV; Polozov, GI; Osipovich, NP; Rytik, PG; Kucherov, II; Chernyavskaya, AA; Sorokin, VL; Shadyro, OI,期刊:European Journal of Medicinal Chemistry, 页码:1536-1542 , 文章类型: Article,,卷期:2008年43-7]
Co(II) and Ni(II) complexes with 4,6-di-tert-butyl-3-[(2-hydroxyethyl)thio]benzene-1,2-diol (L) have been synthesized and characterized by means of elemental analysis, TG/DTA, FT-IR, ESR, UV-vis, XRD, magnetic suscept...
- Synthesis of novel substituted 1,3-diaryl propenone derivatives and their antimalarial activity in vitro
[作者:Mishra, N; Arora, P; Kumar, B; Mishra, LC; Bhattacharya, A; Awasthi, SK; Bhasin, VK,期刊:European Journal of Medicinal Chemistry, 页码:1530-1535 , 文章类型: Article,,卷期:2008年43-7]
The synthesis of novel 1,3-diaryl propenone derivatives and their antimalarial activity in vitro against asexual blood stages of human malaria parasite, Plasmodium falciparum, are described. Chalcone derivatives were ...
|