- Evidence of mitochondrial dysfunction in fragile X-associated tremor/ataxia syndrome
[作者:Ross-Inta, C; Omanska-Klusek, A; Wong, S; Barrow, C; Garcia-Arocena, D; Iwahashi, C; Berry-Kravis, E; Hagerman, RJ; Hagerman, PJ; Giulivi, C,期刊:Biochemical Journal, 页码:545-552 , 文章类型: Article,,卷期:2010年429-Part 3]
- FXTAS (fragile X-associated tremor/ataxia syndrome) is a late-onset neurodegenerative disorder that affects individuals who are carriers of premutation expansions (55-200 CGG repeats) in the 5' untranslated region of the...
- Effect of 8-oxoguanine and abasic site DNA lesions on in vitro elongation by human DNA polymerase epsilon in the presence of replication protein A and proliferating-cell nuclear antigen
[作者:Locatelli, GA; Pospiech, H; Le Gac, NT; van Loon, B; Hubscher, U; Parkkinen, S; Syvaoja, JE; Villani, G,期刊:Biochemical Journal, 页码:573-582 , 文章类型: Article,,卷期:2010年429-Part 3]
- DNA pol (polymerase) epsilon is thought to be the leading strand replicase in eukaryotes. In the present paper, we show that human DNA pot epsilon can efficiently bypass an 8-oxo-G (7,8-dihydro-8-oxoguanine) lesion on th...
- Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells
[作者:Evans, IM; Bagherzadeh, A; Charles, M; Raynham, T; Ireson, C; Boakes, A; Kelland, L; Zachary, IC,期刊:Biochemical Journal, 页码:565-572 , 文章类型: Article,,卷期:2010年429-Part 3]
- VEGF (vascular endothelial growth factor) plays an essential role in angiogenesis during development and in disease largely mediated by signalling events initiated by binding of VEGF to its receptor, VEGFR2 (VEGF recepto...
- Regulation of renal sodium-dependent phosphate co-transporter genes (Npt2a and Npt2c) by all-trans-retinoic acid and its receptors
[作者:Masuda, M; Yamamoto, H; Kozai, M; Tanaka, S; Ishiguro, M; Takei, Y; Nakahashi, O; Ikeda, S; Uebanso, T; Taketani, Y; Segawa, H; Miyamoto, K; Takeda, E,期刊:Biochemical Journal, 页码:583-592 , 文章类型: Article,,卷期:2010年429-Part 3]
- The type II sodium-dependent phosphate co-transporters Npt2a and Npt2c play critical roles in the reabsorption of P-i by renal proximal tubular cells. The vitamin A metabolite ATRA (all-trans-retinoic acid) is important ...
- Translational control of the sterol-regulatory transcription factor SREBP-1 mRNA in response to serum starvation or ER stress is mediated by an internal ribosome entry site
[作者:Damiano, F; Alemanno, S; Gnoni, GV; Siculella, L,期刊:Biochemical Journal, 页码:603-612 , 文章类型: Article,,卷期:2010年429-Part 3]
- SREBPs (sterol-regulatory-element-binding proteins) are a family of transcription factors that modulate the expression of several enzymes implicated in endogenous cholesterol, fatty acid, triacylelycerol and phospholipid...
- Desmosomes: adhesive strength and signalling in health and disease
[作者:Thomason, HA; Scothern, A; McHarg, S; Garrod, DR,期刊:Biochemical Journal, 页码:419-433 , 文章类型: Review,,卷期:2010年429-Part 3]
- Desmosomes are intercellular junctions whose primary function is strong intercellular adhesion, known as hyperadhesion. In the present review, we discuss how their structure appears to support this function as well as ho...
- Ferritin does not donate its iron for haem synthesis in macrophages
[作者:Mikhael, M; Sheftel, AD; Ponka, P,期刊:Biochemical Journal, 页码:463-471 , 文章类型: Article,,卷期:2010年429-Part 3]
- Iron is essential for all life, yet can be dangerous under certain conditions. Iron storage by the 24-subunit protein ferritin renders excess amounts of the metal non-reactive and, consequentially, ferritin is crucial fo...
- NF-kappa B mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance
[作者:Dasgupta, S; Bhattacharya, S; Biswas, A; Majumdar, SS; Mukhopadhyay, S; Ray, S; Bhattacharya, S,期刊:Biochemical Journal, 页码:451-462 , 文章类型: Article,,卷期:2010年429-Part 3]
- Fetuin-A. a hepatic secretory protein, has recently been implicated in insulin resistance and Type 2 diabetes. It is an endogenous inhibitor of insulin receptor tyrosine kinase. However, regulation of fetuin-A synthesis ...
- Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP
[作者:Ramos, IB; Miranda, K; Pace, DA; Verbist, KC; Lin, FY; Zhang, YH; Oldfield, E; Machado, EA; De Souza, W; Docampo, R,期刊:Biochemical Journal, 页码:485-495 , 文章类型: Article,,卷期:2010年429-Part 3]
- Acidocalcisomes are acidic calcium-storage compartments described from bacteria to humans and characterized by their high content in poly P (polyphosphate), a linear polymer of many tens to hundreds of P; residues linked...
- The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants
[作者:Churko, JM; Langlois, S; Pan, XY; Shao, Q; Laird, DW,期刊:Biochemical Journal, 页码:473-483 , 文章类型: Article,,卷期:2010年429-Part 3]
- Although there are currently 62 mutants of Cx43 (connexin43) that can cause ODDD (oculodentodigital dysplasia), only two mutants have also been reported to cause palmar plantar hyperkeratosis. To determine how mutants of...
- Functional characterization of leucine-specific domain 1 from eukaryal and archaeal leucyl-tRNA synthetases
[作者:Zhou, XL; Wang, M; Tan, M; Huang, QA; Eriani, G; Wang, ED,期刊:Biochemical Journal, 页码:505-513 , 文章类型: Article,,卷期:2010年429-Part 3]
- LeuRS (leucyl-tRNA synthetase) catalyses the esterification of tRNAs(Leu) with leucine. This family of enzymes is divided into prokaryotic and eukaryal/archaeal groups according to the presence and position of specific i...
- Duration of fusion pore opening and the amount of hormone released are regulated by myosin II during kiss-and-run exocytosis
[作者:Aoki, R; Kitaguchi, T; Oya, M; Yanagihara, Y; Sato, M; Miyawaki, A; Tsuboi, T,期刊:Biochemical Journal, 页码:497-504 , 文章类型: Article,,卷期:2010年429-Part 3]
- Since the fusion pore of the secretory vesicle is resealed before complete dilation during 'kiss-and-run' exocytosis, their cargoes are not completely released. Although the transient fusion pore is kept open for several...
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