- Ligand-Based Computer-Aided Discovery of Tyrosinase Inhibitors. Applications of the TOMOCOMD-CARDD Method to the Elucidation of New Compounds
[作者:Marrero-Ponce, Y; Casanola-Martin, GM; Khan, MTH; Torrens, F; Rescigno, A; Abad, C,期刊:Current Pharmaceutical Design, 页码:2601-2624 , 文章类型: Review,,卷期:2010年16-24]
- In this review an overview of the application of computational approaches is given. Specifically, the uses of Quantitative Structure-Activity Relationship (QSAR) methods for in silico identification of new families of co...
- Drug Discovery and Design for Complex Diseases through QSAR Computational Methods
[作者:Munteanu, CR; Fernandez-Blanco, E; Seoane, JA; Izquierdo-Novo, P; Rodriguez-Fernandez, JA; Prieto-Gonzalez, JM; Rabunal, JR; Pazos, A,期刊:Current Pharmaceutical Design, 页码:2640-2655 , 文章类型: Review,,卷期:2010年16-24]
- There is a need for the study of complex diseases due to their important impact on our society. One of the solutions involves the theoretical methods which are fast and efficient tools that can lead to the discovery of n...
- QSAR, Docking, and CoMFA Studies of GSK3 Inhibitors
[作者:Garcia, I; Fall, Y; Gomez, G,期刊:Current Pharmaceutical Design, 页码:2666-2675 , 文章类型: Review,,卷期:2010年16-24]
- GSK-3 inhibitors are interesting candidates to develop anti-Alzheimer compounds. GSK-3 beta are also interesting as antiparasitic compounds active against Plasmodium falciparum, Trypanosoma brucei, and Leishmania donovan...
- Ontologies of Drug Discovery and Design for Neurology, Cardiology and Oncology
[作者:Vazquez-Naya, JM; Martinez-Romero, M; Porto-Pazos, AB; Novoa, F; Valladares-Ayerbes, M; Pereira, J; Munteanu, CR; Dorado, J,期刊:Current Pharmaceutical Design, 页码:2724-2736 , 文章类型: Review,,卷期:2010年16-24]
- The complex diseases in the field of Neurology, Cardiology and Oncology have the most important impact on our society. The theoretical methods are fast and they involve some efficient tools aimed at discovering new activ...
- Predicting Drugs and Proteins in Parasite Infections with Topological Indices of Complex Networks: Theoretical Backgrounds, Applications and Legal Issues
[作者:Gonzalez-Diaz, H; Romaris, F; Duardo-Sanchez, A; Perez-Montoto, LG; Prado-Prado, F; Patlewicz, G; Ubeira, FM,期刊:Current Pharmaceutical Design, 页码:2737-2764 , 文章类型: Review,,卷期:2010年16-24]
- Quantitative Structure-Activity Relationship (QSAR) models have been used in Pharmaceutical design and Medicinal Chemistry for the discovery of anti-parasite drugs. QSAR models predict biological activity using as input ...
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