个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共33条记录   The Importance of Doing Trials Right While Doing the Right Trials [作者：Dilts, DM; Cheng, SK,期刊：Clinical Cancer Research, 页码：3-5 , 文章类型： Article，,卷期：2012年18-1] Effort is being expended in investigating efficiency measures (i.e., doing trials right) through achievement of accrual and endpoint goals for clinical trials. It is time to assess the impact of such trials on meeting th... Elusive Extranuclear Estrogen Receptors in Breast Cancer [作者：Levin, ER,期刊：Clinical Cancer Research, 页码：6-8 , 文章类型： Article，,卷期：2012年18-1] Estrogen receptors at the plasma membrane and cytoplasm have been difficult to detect in breast cancer specimens. New imaging approaches are needed to determine the percentage of cancers expressing extranuclear estrogen ... Vemurafenib and BRAF Inhibition: A New Class of Treatment for Metastatic Melanoma [作者：Luke, JJ; Hodi, FS,期刊：Clinical Cancer Research, 页码：9-14 , 文章类型： Article，,卷期：2012年18-1] The U.S. Food and Drug Administration recently approved vemurafenib for the treatment of BRAF valine in exon 15, at codon 600 (V600E) mutant metastatic melanoma. Vemurafenib is a competitive small-molecule serine-threoni... Molecular Pathways: Targeting Proteasomal Protein Degradation in Cancer [作者：Molineaux, SM,期刊：Clinical Cancer Research, 页码：15-20 , 文章类型： Article，,卷期：2012年18-1] With the approval by the U.S. Food and Drug Administration of bortezomib for the treatment of multiple myeloma and mantle cell lymphoma, the proteasome was clinically validated as a target in oncology. The proteasome is ... Drug Development: Portals of Discovery [作者：Bates, SE; Amiri-Kordestani, L; Giaccone, G,期刊：Clinical Cancer Research, 页码：23-32 , 文章类型： Article，,卷期：2012年18-1] A British humorist said, "There is much to be said for failure. It is much more interesting than success." This CCR Focus section is aimed at identifying lessons to be learned from difficulties encountered in recent year... BRAF Inhibitors for the Treatment of Metastatic Melanoma: Clinical Trials and Mechanisms of Resistance [作者：Alcala, AM; Flaherty, KT,期刊：Clinical Cancer Research, 页码：33-39 , 文章类型： Article，,卷期：2012年18-1] The efficacy of selective BRAF inhibitors has now been established in the 50% of patients with metastatic melanoma whose tumors harbor activating mutations. However, for the vast majority of patients, responses persist f... The Insulin Receptor/Insulin-Like Growth Factor Receptor Family as a Therapeutic Target in Oncology [作者：Pollak, M,期刊：Clinical Cancer Research, 页码：40-50 , 文章类型： Article，,卷期：2012年18-1] Over the past decade, encouraging preclinical and early clinical data concerning the relevance of the insulin receptor/insulin-like growth factor (IGF) receptor family to neoplasia led to ambitious clinical trial program... Inhibitors Targeting Mitosis: Tales of How Great Drugs against a Promising Target Were Brought Down by a Flawed Rationale [作者：Komlodi-Pasztor, E; Sackett, DL; Fojo, AT,期刊：Clinical Cancer Research, 页码：51-63 , 文章类型： Article，,卷期：2012年18-1] Although they have been advocated with an understandable enthusiasm, mitosis-specific agents such as inhibitors of mitotic kinases and kinesin spindle protein have not been successful clinically. These drugs were develop... Hsp90 Molecular Chaperone Inhibitors: Are We There Yet? [作者：Neckers, L; Workman, P,期刊：Clinical Cancer Research, 页码：64-76 , 文章类型： Article，,卷期：2012年18-1] Heat shock protein (Hsp) 90 is an ATP-dependent molecular chaperone that is exploited by malignant cells to support activated oncoproteins, including many cancer-associated kinases and transcription factors, and it is es... Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy [作者：Kemp, CD; Rao, M; Xi, SC; Inchauste, S; Mani, H; Fetsch, P; Filie, A; Zhang, M; Hong, JA; Walker, RL; Zhu, YLJ; Ripley, RT; Mathur, A; Liu, F; Yang, MC; Meltzer, PA; Marquez, VE; De Rienzo, A; Bueno, R; Schrump, DS,期刊：Clinical Cancer Research, 页码：77-90 , 文章类型： Article，,卷期：2012年18-1] Purpose: Polycomb group (PcG) proteins are critical epigenetic mediators of stem cell pluripotency, which have been implicated in the pathogenesis of human cancers. This study was undertaken to examine the frequency and ... Eph-B2/Ephrin-B2 Interaction Plays a Major Role in the Adhesion and Proliferation of Waldenstrom's Macroglobulinemia [作者：Azab, F; Azab, AK; Maiso, P; Calimeri, T; Flores, L; Liu, Y; Quang, P; Roccaro, AM; Sacco, A; Ngo, HT; Zhang, Y; Morgan, BL; Carrasco, RD; Ghobrial, IM,期刊：Clinical Cancer Research, 页码：91-104 , 文章类型： Article，,卷期：2012年18-1] Purpose: The ephrin receptors (Eph) are found in a wide range of cancers and correlate with metastasis. In this study, we characterized the role of Eph-B2 receptor in the interaction of Waldenstrom's macroglobulinemia (W... Costimulatory Protein 4IgB7H3 Drives the Malignant Phenotype of Glioblastoma by Mediating Immune Escape and Invasiveness [作者：Lemke, D; Pfenning, PN; Sahm, F; Klein, AC; Kempf, T; Warnken, U; Schnolzer, M; Tudoran, R; Weller, M; Platten, M; Wick, W,期刊：Clinical Cancer Research, 页码：105-117 , 文章类型： Article，,卷期：2012年18-1] Purpose: Recent work points out a role of B7H3, a member of the B7-family of costimulatory proteins, in conveying immunosuppression and enforced invasiveness in a variety of tumor entities. Glioblastoma is armed with eff... Cytoplasmic Estrogen Receptor in Breast Cancer [作者：Welsh, AW; Lannin, DR; Young, GS; Sherman, ME; Figueroa, JD; Henry, NL; Ryden, L; Kim, C; Love, RR; Schiff, R; Rimm, DL,期刊：Clinical Cancer Research, 页码：118-126 , 文章类型： Article，,卷期：2012年18-1] Purpose: In addition to genomic signaling, it is accepted that estrogen receptor-alpha (ER alpha) has nonnuclear signaling functions, which correlate with tamoxifen resistance in preclinical models. However, evidence for... STAT5A-Mediated SOCS2 Expression Regulates Jak2 and STAT3 Activity Following c-Src Inhibition in Head and Neck Squamous Carcinoma [作者：Sen, B; Peng, SH; Woods, DM; Wistuba, I; Bell, D; El-Naggar, AK; Lai, SY; Johnson, FM,期刊：Clinical Cancer Research, 页码：127-139 , 文章类型： Article，,卷期：2012年18-1] Purpose: The inhibition of c-Src results in a striking reduction in cancer cell invasion, but the effect on cell survival is modest. Defining mechanisms that limit apoptosis following c-Src inhibition could result in an ... Phenylarsine Oxide Induces Apoptosis in Bax- and Bak-Deficient Cells through Upregulation of Bim [作者：Ni, BY; Ma, Q; Li, BW; Zhao, LX; Liu, Y; Zhu, YS; Chen, Q,期刊：Clinical Cancer Research, 页码：140-151 , 文章类型： Article，,卷期：2012年18-1] Purpose: Bax and Bak are regarded as key mediators for cytochrome c (Cyt c) release and apoptosis. Loss of Bax or Bak is often reported in human cancers and renders resistance of these cancerous cells to chemotherapy. He... A CDD Polymorphism as Predictor of Capecitabine-Induced Hand-Foot Syndrome-Letter [作者：Ciccolini, J; Evrard, A; Lacarelle, B,期刊：Clinical Cancer Research, 页码：317-317 , 文章类型： Letter，,卷期：2012年18-1]