- Use of cethromycin, a new ketolide, for treatment of community-acquired respiratory infections
[作者:Hammerschlag, MR; Sharma, R,期刊:Expert opinion on investigational drugs, 页码:387-400 , 文章类型: Article,,卷期:2008年17-3]
Background: The ketolides, are a subclass of macrolides, which were designed specifically to overcome macrolide-resistant respiratory pathogens. Ketolides lack the cladinose sugar, which is replaced with a 3-ketone gr...
- Vaspin: a novel serpin with insulin-sensitizing effects
[作者:Wada, J,期刊:Expert opinion on investigational drugs, 页码:327-333 , 文章类型: Review,,卷期:2008年17-3]
Background: A variety of substances, including free fatty acids, leptin, tumor necrosis factor-a, acylation-stimulating protein, adiponectin, and resistin, are secreted by adipocytes. They modulate insulin sensitivity...
- New taxanes in development
[作者:Ferlini, C; Gallo, D; Scambia, G,期刊:Expert opinion on investigational drugs, 页码:335-347 , 文章类型: Review,,卷期:2008年17-3]
Background: Taxanes are presently widely employed for the medical treatment of cancer. However, despite the huge clinical success, these agents exhibit clinical problems related to poor drug solubility, toxicity and, ...
- Alitretinoin: a comprehensive a review
[作者:Cheng, C; Michaels, J; Scheinfeld, N,期刊:Expert opinion on investigational drugs, 页码:437-443 , 文章类型: Review,,卷期:2008年17-3]
Background: Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma). Studies are being carrie...
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