- Ixabepilone, a novel epothilone analog in the treatment of breast cancer
[作者:Pivot, X; Villanueva, C; Chaigneau, L; Nguyen, T; Demarchi, M; Maurina, T; Stein, U; Borg, C,期刊:Expert opinion on investigational drugs, 页码:593-599 , 文章类型: Article,,卷期:2008年17-4]
Background: Natural epothilones and their analogs promote tumor cell death by binding to tubulin and stabilizing microtubules, causing cell death. Ixabepilone (BMS-247550, Ixempra (R)) is an epothilone analog that opt...
- A comparison of pentane-1,5-diol to other diols for use in dermatology
[作者:Sundberg, JJ; Faergemann, J,期刊:Expert opinion on investigational drugs, 页码:601-610 , 文章类型: Article,,卷期:2008年17-4]
Background: The use of pentane-1,5-diol in topical pharmaceutical products is relatively new compared with, e.g., propane-1,2-diol (propylene glycol), also an aliphatic diol, which has been used for many years. Yet, w...
- Investigational developments for the treatment of progesterone-dependent diseases
[作者:Moller, C; Hoffmann, J; Kirkland, TA; Schwedet, W,期刊:Expert opinion on investigational drugs, 页码:469-479 , 文章类型: Review,,卷期:2008年17-4]
Background: Clinical evidence has shown that conditions such as uterine fibroids, endometriosis and breast cancer are progesterone-dependent diseases. Therefore, progesterone receptor (PR) antagonists and selective PR...
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