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  • Selenium and human health
    [作者:Rayman, MP,期刊:Lancet, 页码:1256-1268 , 文章类型: Review,,卷期:2012年379-9822]
  • Selenium is incorporated into selenoproteins that have a wide range of pleiotropic effects, ranging from anti oxidant and anti-inflammatory effects to the production of active thyroid hormone. In the past 10 years, the d...
  • Hepatocellular carcinoma
    [作者:Forner, A; Llovet, JM; Bruix, J,期刊:Lancet, 页码:1245-1255 , 文章类型: Article,,卷期:2012年379-9822]
  • Hepatocellular carcinoma is the sixth most prevalent cancer and the third most frequent cause of cancer-related death. Patients with cirrhosis are at highest risk of developing this malignant disease, and ultrasonography...
  • Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies
    [作者:Sarwar, N; Butterworth, AS; Freitag, DF; Gregson, J; Willeit, P; Gorman, DN; Gao, P; Saleheen, D; Rendon, A; Nelson, CP; Braund, PS; Hall, AS; Chasman, DI; Tybjaerg-Hansen, A; Chambers, JC; Benjamin, EJ; Franks, PW; Clarke, R; Wilde, AAM; Trip, MD; Steri, M; Witteman, JCM; Qi, L; van der Schoot, CE; de Faire, U; Erdmann, J; Stringham, HM; Koenig, W; Rader, DJ; Melzer, D; Reich, D; Psaty, BM; Kleber, ME; Panagiotakos, DB; Willeit, J; Wennberg, P; Woodward, M; Adamovic, S; Rimm, EB; Meade, TW; Gillum, RF; Shaffer, JA; Hofman, A; Onat, A; Sundstrom, J; Wassertheil-Smoller, S; Mellstrom, D; Gallacher, J; Cushman, M; Tracy, RP; Kauhanen, J; Karlsson, M; Salonen, JT; Wilhelmsen, L; Amouyel, P; Cantin, B; Best, LG; Ben-Shlomo, Y; Manson, JE; Davey-Smith, G; de Bakker, PIW; O'Donnell, CJ; Wilson, JF; Wilson, AG; Assimes, TL; Jansson, JO; Ohlsson, C; Tivesten, A; Ljunggren, O; Reilly, MP; Hamsten, A; Ingelsson, E; Cambien, F; Hung, J; Thomas, GN; Boehnke, M; Schunkert, H; Asselbergs, FW; Kastel,期刊:Lancet, 页码:1205-1213 , 文章类型: Article,,卷期:2012年379-9822]
  • Background Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To...
  • The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
    [作者:Swerdlow, DI; Holmes, MV; Kuchenbaecker, KB; Engmann, JEL; Shah, T; Sofat, R; Guo, YR; Chung, C; Peasey, A; Ster, RP; Mooijaart, SP; Ireland, HA; Leusink, M; Langenberg, C; Li, K; Palmen, J; Howard, P; Cooper, JA; Drenos, F; Hardy, J; Nalls, MA; Li, YR; Lowe, G; Stewart, M; Bielinski, SJ; Peto, J; Timpson, NJ; Gallacher, J; Dunlop, M; Houlston, R; Tomlinson, I; Tzoulaki, I; Luan, J; Boer, JMA; Forouhi, NG; Onland-Moret, NC; van der Schouw, YT; Schnabel, RB; Hubacek, JA; Kubinova, R; Baceviciene, M; Tamosiunas, A; Pajak, A; Topor-Madry, R; Malyutina, SA; Baldassarre, D; Sennblad, B; Tremoli, E; de Faire, U; Ferrucci, L; Bandenelli, S; Tanaka, T; Meschia, JF; Singleton, A; Navis, G; Leach, IM; Bakker, SJL; Gansevoort, RT; Ford, I; Epstein, SE; Burnett, MS; Devaney, JM; Jukema, JW; Westendorp, RGJ; de Borst, GJ; van der Graaf, Y; de Jong, PA; Maitland-van der Zee, AH; Klungel, OH; de Boer, A; Doevendans, PA; Stephens, JW; Eaton, CB; Robinson, JG; Manson, JE; Fowkes, FGR; Frayling, TM; Pri,期刊:Lancet, 页码:1214-1224 , 文章类型: Article,,卷期:2012年379-9822]
  • Background A high circulating concentration of interleukin 6 is associated with increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a monoclonal antibody (tocilizumab) licensed fo...
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