- CRIM1 is Expressed at Higher Levels in Drug-resistant than in Drug-sensitive Myeloid Leukemia HL60 Cells
[作者:Prenkert, M; Uggla, B; Tidefelt, U; Strid, H,期刊:Anticancer Research, 页码:4157-4161 , 文章类型: Article,,卷期:2010年30-10]
- Aim: The aim of this study was to explore possible differences in the mRNA expression levels of CRIM1, SMAD5, BMP4 and BMP7 in sensitive (S) and multidrug-resistant (R0.5) myeloid leukemia HL60 cells. Materials and Metho...
- Clinicopathological Significance of p53, Hypoxia-inducible Factor 1 alpha, and Vascular Endothelial Growth Factor Expression in Colorectal Cancer
[作者:Kwon, HC; Kim, SH; Oh, SY; Lee, S; Kwon, KA; Choi, HJ; Park, KJ; Kim, HJ; Roh, MS,期刊:Anticancer Research, 页码:4163-4168 , 文章类型: Article,,卷期:2010年30-10]
- Background: The principal objective of this study was to evaluate the prognostic significances of p53, hypoxia inducible factor-1 alpha (HIF-1 alpha), and vascular endothelial growth factor (VEGF) expression in colorecta...
- Up-regulation of Fibronectin and Tissue Transglutaminase Promotes Cell Invasion Involving Increased Association with Integrin and MMP Expression in A431 Cells
[作者:Chen, SH; Lin, CY; Lee, LT; Chang, GD; Lee, PP; Hung, CC; Kao, WT; Tsai, PH; Schally, AV; Hwang, JJ; Lee, MT,期刊:Anticancer Research, 页码:4177-4186 , 文章类型: Article,,卷期:2010年30-10]
- In human tumors, fibronectin (FN) expression is positively associated with tumor metastatic potential and matrix metalloproteinase (MMP) secretion. Additionally, tissue transglutaminase (TG2) is implicated as playing an ...
- The Novel Quinolone CHM-1 Induces DNA Damage and Inhibits DNA Repair Gene Expressions in a Human Osterogenic Sarcoma Cell Line
[作者:Chen, HY; Lu, HF; Yang, JS; Kuo, SC; Lo, C; Yang, MD; Chiu, TH; Chueh, FS; Ho, HC; Ko, YC; Chung, JG,期刊:Anticancer Research, 页码:4187-4192 , 文章类型: Article,,卷期:2010年30-10]
- 20-Fluoro-6,7-methylenedioxy-2-phenyl-4-quino-lone (CHM-1) has been reported to induce cell cycle arrest and apoptosis in many types of cancer cells. However, there is no available information to show CHM-1 affecting DNA...
- Inhibition of Myc Effectively Targets KRAS Mutation-positive Lung Cancer Expressing High Levels of Myc
[作者:Fukazawa, T; Maeda, Y; Matsuoka, J; Yamatsuji, T; Shigemitsu, K; Morita, I; Faiola, F; Durbin, ML; Soucek, L; Naomoto, Y,期刊:Anticancer Research, 页码:4193-4200 , 文章类型: Article,,卷期:2010年30-10]
- Myc is an oncogenic transcription factor that promotes tumorigenesis. Recently, a dominant negative form of Myc (Omomyc) was shown to cause regression of lung tumors in a mouse model of lung cancer caused by KRAS mutatio...
- Antitumour and Cytogenetic Effects of Modified Steroidal Derivatives of Propenoic Acid: In Vivo/In Vitro Studies
[作者:Papageorgiou, A; Mourelatos, C; Geromichalos, G; Geromichalou, E; Dalezis, P; Lialiaris, T,期刊:Anticancer Research, 页码:4201-4204 , 文章类型: Article,,卷期:2010年30-10]
- Background: Modified steroidal derivatives (PK11-PK14) of p-bis(2-chloroethyl)aminophenyl propenate (PK15) were used to study their antitumour activity on Lewis lung carcinoma (LLC) and their effect on sister chromatid e...
- The Joint Effect of hOGG1 Single Nucleotide Polymorphism and Betel Quid Chewing on Oral Cancer in Taiwan
[作者:Tsou, YA; Hua, CH; Tseng, HC; Hsu, CF; Tsai, CW; Sun, SS; Tsai, RY; Tsai, MH; Bau, DT,期刊:Anticancer Research, 页码:4205-4208 , 文章类型: Article,,卷期:2010年30-10]
- Aim: To evaluate the association and interaction among hOGG1 genotypic polymorphism, betel quid chewing status and oral cancer risk in Taiwan. Materials and Methods: The well-known polymorphic variants of hOGG1, codon 32...
- Molecular Predictors of Combination Targeted Therapies (Cetuximab, Bevacizumab) in Irinotecan-Refractory Colorectal Cancer (BOND-2 Study)
[作者:Zhang, W; Azuma, M; Lurje, G; Gordon, MA; Yang, DY; Pohl, A; Ning, Y; Bohanes, P; Gerger, A; Winder, T; Hollywood, E; Danenberg, KD; Saltz, L; Lenz, HJ,期刊:Anticancer Research, 页码:4209-4217 , 文章类型: Article,,卷期:2010年30-10]
- Background: To test whether intratumoral gene expression levels and germline polymorphisms predict clinical outcome in metastatic colorectal cancer (mCRC) patients treated with cetuximab and bevacizumab plus irinotecan (...
- Inhibition of Notch Signaling Reduces the Stem-like Population of Breast Cancer Cells and Prevents Mammosphere Formation
[作者:Grudzien, P; Lo, S; Albain, KS; Robinson, P; Rajan, P; Strack, PR; Golde, TE; Miele, L; Foreman, KE,期刊:Anticancer Research, 页码:3853-3867 , 文章类型: Article,,卷期:2010年30-10]
- Background: Cancer stem cells (CSCs) are believed to be responsible for breast cancer formation and recurrence; therefore, therapeutic strategies targeting CSCs must be developed. One approach may be targeting signaling ...
- Inhibition of BCL-2 in Small Cell Lung Cancer Cell Lines with Oblimersen, an Antisense BCL-2 Oligodeoxynucleotide (ODN): In Vitro and In Vivo Enhancement of Radiation Response
[作者:Loriot, Y; Mordant, P; Brown, BD; Bourhis, J; Soria, JC; Deutsch, E,期刊:Anticancer Research, 页码:3869-3878 , 文章类型: Article,,卷期:2010年30-10]
- Background: Oblimersen, an ODN targeting BCL-2 RNA, has been shown to be effective in reducing BCL-2 expression in vitro and in in vivo models engineered to overexpress BCL-2. The present study evaluated the efficacy of ...
- Poly-N-acetyl Glucosamine Gel Matrix as a Non-Viral Delivery Vector for DNA-Based Vaccination
[作者:Salem, ML; Demcheva, M; Gillanders, WE; Cole, DJ; Vournakis, JN,期刊:Anticancer Research, 页码:3889-3894 , 文章类型: Review,,卷期:2010年30-10]
- Intramuscular administration of plasmid DNA vaccines is one of the main delivery approaches that can generate antigen specific T cell responses. However, major limitations of the intramuscular delivery strategy are the l...
- EGFR-Activating Mutations Are Not Present in Breast Tumors of Japanese Patients
[作者:Uramoto, H; Shimokawa, H; Nagata, Y; Ono, K; Hanagiri, T,期刊:Anticancer Research, 页码:4219-4222 , 文章类型: Article,,卷期:2010年30-10]
- Background: Despite advances in treatment, recurrent breast cancer remains a lethal disease. The epidermal growth factor receptor family has been suggested to play a role in breast cancer. However, no investigations of t...
- L-type Amino-Acid Transporter 1 Expression Predicts the Response to Preoperative Hyperthermo-Chemoradiotherapy for Advanced Rectal Cancer
[作者:Ebara, T; Kaira, K; Saito, JI; Shioya, M; Asao, T; Takahashi, T; Sakurai, H; Kanai, Y; Kuwano, H; Nakano, T,期刊:Anticancer Research, 页码:4223-4227 , 文章类型: Article,,卷期:2010年30-10]
- Aim: To evaluate whether expression of L-type amino acid transporter 1 (LAT1) in pretreatment rectal cancer biopsies is predictive of tumour response to neoadjuvant hyperthermo-chemoradiotherapy (HCRT). Patients and Meth...
- Concordant Analysis of KRAS Status in Primary Colon Carcinoma and Matched Metastasis
[作者:Marian, P; Lae, M; Degeorges, A; Cacheux, W; Lappartient, E; Margogne, A; Pierga, JY; Girre, V; Mignot, L; Falcou, MC; Salmon, RJ; Delattre, O; De Cremoux, P,期刊:Anticancer Research, 页码:4229-4235 , 文章类型: Article,,卷期:2010年30-10]
- KRAS somatic mutations are the main predictive factor for non response to EGFR-targeted monoclonal antibodies in metastatic colorectal cancer (mCRC) patients. We compared KRAS mutational status in the primary tumour and ...
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