- Pharmacological Efficacy and Safety Profile of Taranabant in Preclinical Species
[作者：Fong, TM; Shearman, LP; Stribling, DS; Shu, J; Lao, J; Huang, CRR; Xiao, JC; Shen, CP; Tyszkiewicz, J; Strack, AM; DeMaula, C; Hubert, MF; Galijatovic-Idrizbegovic, A; Owen, R; Huber, AC; Lanning, CL,期刊：Drug Development Research, 页码：349-362 , 文章类型： Article，,卷期：2009年70-5]
- Taranabant is a highly selective and potent cannabinoid CB, receptor inverse agonist. We compared the pharmacological properties of taranabant with another inverse agonist, rimonabant, and determined the preclinical safe...
- Improving the Dissolution and Oral Bioavailability of the Poorly Water-soluble Drug Aloe-Emodin by Solid Dispersion With Polyethylene Glycol 6000
[作者：Duan, HG; Wei, YH; Li, BX; Qin, HY; Wu, XA,期刊：Drug Development Research, 页码：363-369 , 文章类型： Article，,卷期：2009年70-5]
- Solid dispersions (SDs) of aloe-emodin (AE) and polyethylene glycol 6000 (PEG6000) with different drug loadings were prepared, characterized by scanning electron microscopy (SEM) and differential scanning calorimetry (DS...
- Nonylphenol-Induced Cytosolic Ca2+ Elevation and Death in Renal Tubular Cells
[作者：Tsai, JY; Huang, CC; Cheng, HH; Lin, KL; Liao, WC; Jan, CR,期刊：Drug Development Research, 页码：370-377 , 文章类型： Article，,卷期：2009年70-5]
- Nonylphenol is an environmental endocrine disrupter. The effect of nonylphenol on intracellular free Ca2+ levels ([Ca2+](i)) and viability in Madin-Darby canine kidney (MDCK) cells was explored. Nonylphenol increased [Ca...
- Scopoletin Induces Apoptosis of Fibroblast-Like Synoviocytes From Adjuvant Arthritis Rats by a Mitochondrial-Dependent Pathway
[作者：Li, Y; Dai, Y; Liu, M; Pan, R; Luo, YB; Xia, YF; Xia, XF,期刊：Drug Development Research, 页码：378-385 , 文章类型： Article，,卷期：2009年70-5]
- Scopoletin is a naturally occurring coumarin compound found in many medicinal plants, such as Erycibe obtusifolia Benth and Aster tataricus. Our previous studies have demonstrated that this compound could ameliorate adju...
- Synergistic Antiallodynic Interaction of the Metamizol-Gabapentin Combination
[作者：Ortega-Varela, LF; Herrera, JE; Caram-Salas, NL; Rocha-Gonzalez, HI; Torres-Lopez, JE; Granados-Soto, V,期刊：Drug Development Research, 页码：386-394 , 文章类型： Article，,卷期：2009年70-5]
- This study was designed to evaluate the possible antiallodynic interaction between metamizol and gabapentin in rats submitted to L5/L6 spinal nerve ligation. Metamizol, gahapentin, or a combination of both drugs were ass...
- The Evaluation of a Biodegradable Dental Chip Containing Chlorhexidine in Chitosan Base as a Targeted Drug Delivery in the Management of Chronic Periodontitis in Patients
[作者：Jothi, MV; Bhat, KM; Pratibha, PK; Bhat, GS,期刊：Drug Development Research, 页码：395-401 , 文章类型： Article，,卷期：2009年70-5]
- Chlorhexidine is one of the commonly used agents in the treatment of periodontitis. In the present study, a biodegradable dental chip of chitosan containing chlorhexidine was evaluated both in vitro and in vivo, as a tar...
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