Background: Mitotic kinesins are attractive targets in cancer chemotherapy. A large number of small-molecule inhibitors of kinesin spindle protein (KSP) and centromere-associated protein E (CENP-E) have been discovere...
Background: Engineered adenoviruses are being increasingly explored as immunoprophylactic or immunotherapeutic vaccine vectors. Encouraging data from preclinical studies using human adenovirus vectors carrying differe...
Background: Fungi are the most insidious pathogens, since they are eukaryotic microorganisms. Systemic infections are potentially fatal and are a growing danger for human health. There is increasing emergence of funga...
Background: Chemokines are a large family of chemotactic proteins that direct migration of leukocytes within the different districts of the body in health and disease. The main function of chemokines is to attract leu...
Background: Glucocorticoids are the most potent anti-inflammatory drugs available and allow successful treatment of several chronic inflammatory and autoimmune diseases. The discovery of the molecular mechanisms of th...
Background: Organometallic alkyne complexes of the hexacarbonyl dicobalt type (hexacarbonyl[mu-eta(4)-(alkyne)]dicobalt (Co - Co) complexes) are an interesting class of compounds used in modern synthetic chemistry and...