- NO donor hybrid compounds as multifunctional therapeutic agents
[作者:Fang, L; Lehmann, J,期刊:Expert Opinion on Therapeutic Patents, 页码:1111-1125 , 文章类型: Review,,卷期:2008年18-10]
Background: In the 1980s, nitric oxide (NO) was found to be a crucial signaling and regulating molecule with wide-ranging functions in the cardiovascular, nervous and immune systems, such as blood vessel relaxation, n...
- PDE7 inhibitors as new drugs for neurological and inflammatory disorders
[作者:Gil, C; Campillo, NE; Perez, DI; Martinez, A,期刊:Expert Opinion on Therapeutic Patents, 页码:1127-1139 , 文章类型: Review,,卷期:2008年18-10]
Background: Phosphodiesterase 7 (PDE7) is a high affinity CAMP-specific PDE whose functional role in T cells has been the subject of some controversy. Recent findings on tissue distribution, however, support the hypot...
- Recent progress in the development of selective S1P1 receptor agonists for the treatment of inflammatory and autoimmune disorders
[作者:Buzard, DJ; Thatte, J; Lerner, M; Edwards, J; Jones, RM,期刊:Expert Opinion on Therapeutic Patents, 页码:1141-1159 , 文章类型: Review,,卷期:2008年18-10]
Background: The sphingosine-1-phosphate receptor 1 (S1P1) belongs to the endothelial differentiation gene family of G-protein-coupled receptors involved in embryonic development, cellular differentiation and survival,...
- Emerging strategies in the diagnosis, prevention and treatment of Chlamydophila pneumoniae infections
[作者:Villegas, E; Camacho, A; Carrillo, JA; Sorlozano, A; Rojas, J; Gutierrez, J,期刊:Expert Opinion on Therapeutic Patents, 页码:1175-1189 , 文章类型: Review,,卷期:2008年18-10]
Background: Chlamydophila pneumoniae infections are a common cause of acute respiratory diseases, including upper respiratory tract infections and pneumonia. Over the past few years, C. pneumoniae infections have been...
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