- Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs
[作者:Brookes, E; de Santiago, I; Hebenstreit, D; Morris, KJ; Carroll, T; Xie, SQ; Stock, JK; Heidemann, M; Eick, D; Nozaki, N; Kimura, H; Ragoussis, J; Teichmann, SA; Pombo, A,期刊:Cell Stem Cell, 页码:157-170 , 文章类型: Article,,卷期:2012年10-2]
- Polycomb repressor complexes (PRCs) are important chromatin modifiers fundamentally implicated in pluripotency and cancer. Polycomb silencing in embryonic stem cells (ESCs) can be accompanied by active chromatin and prim...
- BMP4 Signaling Acts via Dual-Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells
[作者:Li, ZW; Fei, T; Zhang, JP; Zhu, GY; Wang, L; Lu, DY; Chi, XC; Teng, Y; Hou, N; Yang, X; Zhang, HQ; Han, JDJ; Chen, YG,期刊:Cell Stem Cell, 页码:171-182 , 文章类型: Article,,卷期:2012年10-2]
- Extrinsic BMP and LIF signaling collaboratively maintain mouse embryonic stem cell (ESC) pluripotency, whereas appropriate ERK activity is essential for ESC fate commitment. However, how the extrinsic signals restrain ap...
- A Mammary Stem Cell Population Identified and Characterized in Late Embryogenesis Reveals Similarities to Human Breast Cancer
[作者:Spike, BT; Engle, DD; Lin, JC; Cheung, SK; La, J; Wahl, GM,期刊:Cell Stem Cell, 页码:183-197 , 文章类型: Article,,卷期:2012年10-2]
- Gene expression signatures relating mammary stem cell populations to breast cancers have focused on adult tissue. Here, we identify, isolate, and characterize the fetal mammary stem cell (fMaSC) state since the invasive ...
- Infection-Responsive Expansion of the Hematopoietic Stem and Progenitor Cell Compartment in Zebrafish Is Dependent upon Inducible Nitric Oxide
[作者:Hall, CJ; Flores, MV; Oehlers, SH; Sanderson, LE; Lam, EY; Crosier, KE; Crosier, PS,期刊:Cell Stem Cell, 页码:198-209 , 文章类型: Article,,卷期:2012年10-2]
- Hematopoietic stem cells (HSCs) are rare multipotent cells that contribute to all blood lineages. During inflammatory stress, hematopoietic stem and progenitor cells (HSPCs) can be stimulated to proliferate and different...
- Decoupling of Tumor-Initiating Activity from Stable Immunophenotype in HoxA9-Meis1-Driven AML
[作者:Gibbs, KD; Jager, A; Crespo, O; Goltsev, Y; Trejo, A; Richard, CE; Nolan, GP,期刊:Cell Stem Cell, 页码:210-217 , 文章类型: Article,,卷期:2012年10-2]
- Increasing evidence suggests tumors are maintained by cancer stem cells; however, their nature remains controversial. In a HoxA9-Meis1 (H9M) model of acute myeloid leukemia (AML), we found that tumor-initiating activity ...
- Rapid Expansion of Human Hematopoietic Stem Cells by Automated Control of Inhibitory Feedback Signaling
[作者:Csaszar, E; Kirouac, DC; Yu, M; Wang, WJ; Qiao, WL; Cooke, MP; Boitano, AE; Ito, C; Zandstra, PW,期刊:Cell Stem Cell, 页码:218-229 , 文章类型: Article,,卷期:2012年10-2]
- Clinical hematopoietic transplantation outcomes are strongly correlated with the numbers of cells infused. Anticipated novel therapeutic implementations of hematopoietic stem cells (HSCs) and their derivatives further in...
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