- Arhgef1 Regulates alpha 5 beta 1 Integrin-Mediated Matrix Metalloproteinase Expression and Is Required for Homeostatic Lung Immunity
[作者:Hartney, JM; Brown, J; Chu, HW; Chang, LY; Pelanda, R; Torres, RM,期刊:American Journal of Pathology, 页码:1157-1168 , 文章类型: Article,,卷期:2010年176-3]
- Pulmonary immunity depends on the ability of leukocytes to neutralize potentially harmful and frequent insults to the lung, and appropriate regulation of leukocyte migration and adhesion is integral to this process. Arhg...
- Improving Outcomes of Neuroprotection by Minocycline Guides from Cell Culture and Intracerebral Hemorrhage in Mice
[作者:Xue, MZ; Mikliaeva, EI; Casha, S; Zygun, D; Demchuk, A; Yong, VW,期刊:American Journal of Pathology, 页码:1193-1202 , 文章类型: Article,,卷期:2010年176-3]
- Minocycline ameliorates deficits in models of acute and chronic neurological diseases, but many publications do not replicate these results. We tested the hypothesis that a key factor in achieving neurological benefits i...
- Epithelial-Stromal Interaction 1 (EPSTI1) Substitutes for Peritumoral Fibroblasts in the Tumor Microenvironment
[作者:de Neergaard, M; Kim, J; Villadsen, R; Fridriksdottir, AJ; Rank, F; Timmermans-Wielenga, V; Langerod, A; Borresen-Dale, AL; Petersen, OW; Ronnov-Jessen, L,期刊:American Journal of Pathology, 页码:1229-1240 , 文章类型: Article,,卷期:2010年176-3]
- Tumor cells can activate stroma, yet the implication of this activation in terms of reciprocal induction of gene expression in tumor cells is poorly understood. Epithelial Stromal Interaction 1 (EPSTI1) is an interferon ...
- BRCA1 Protein and Nucleolin Colocalize in Breast Carcinoma Tissue and Cancer Cell Lines
[作者:Tulchin, N; Chambon, M; Juan, G; Dikman, S; Strauchen, J; Ornstein, L; Billack, B; Woods, NT; Monteiro, ANA,期刊:American Journal of Pathology, 页码:1203-1214 , 文章类型: Article,,卷期:2010年176-3]
- The breast and ovarian cancer susceptibility gene BRC41 encodes a tumor suppressor. BRCA1 protein, which is involved in DNA damage response, has been thought to be found primarily in cell nuclei. In the present investiga...
- Hepato-Renal Pathology in Pkd2WS25/- Mice, an Animal Model of Autosomal Dominant Polycystic Kidney Disease
[作者:Stroope, A; Radtke, B; Huang, B; Masyuk, T; Torres, V; Ritman, E; LaRusso, N,期刊:American Journal of Pathology, 页码:1282-1291 , 文章类型: Article,,卷期:2010年176-3]
- Polycystic liver diseases, the most important of which are autosomal dominant and autosomal recessive polycystic kidney diseases, are incurable pathological conditions. Animal models that resemble human pathology in thes...
- Macrophage Matrix Metalloproteinase-9 Mediates Epithelial-Mesenchymal Transition in Vitro in Murine Renal Tubular Cells
[作者:Tan, TK; Zheng, GP; Hsu, TT; Wang, Y; Lee, VWS; Tian, XR; Wang, YP; Cao, Q; Wang, Y; Harris, DCH,期刊:American Journal of Pathology, 页码:1256-1270 , 文章类型: Article,,卷期:2010年176-3]
- As a rich source of pro-fibrogenic growth factors and matrix metalloproteinases (MMPs), macrophages are well-placed to play an important role in renal fibrosis. However, the exact underlying mechanisms and the extent of ...
- Murine Cerebral Malaria Is Associated with a Vasospasm-Like Microcirculatory Dysfunction, and Survival upon Rescue Treatment Is Markedly Increased by Nimodipine
[作者:Cabrales, P; Zanini, GM; Meays, D; Frangos, JA; Carvalho, LJM,期刊:American Journal of Pathology, 页码:1306-1315 , 文章类型: Article,,卷期:2010年176-3]
- Brain hemodynamics in cerebral malaria (CM) is poorly understood, with apparently conflicting data showing microcirculatory hypoperfusion and normal or even increased blood flow in large arteries. Using intravital micros...
- Renal Failure Increases Cardiac Histone H3 Acetylation, Dimethylation, and Phosphorylation and the Induction of Cardiomyopathy-Related Genes in Type 2 Diabetes
[作者:Gaikwad, AB; Sayyed, SG; Lichtnekert, J; Tikoo, K; Anders, HJ,期刊:American Journal of Pathology, 页码:1079-1083 , 文章类型: Article,,卷期:2010年176-3]
- The combination of diabetes and renal failure is associated with accelerated cardiomyopathy, but the molecular mechanisms of how renal failure drives diabetic heart disease remain elusive. We speculated that the metaboli...
- Extreme Methylation Values of Imprinted Genes in Human Abortions and Stillbirths
[作者:Pliushch, G; Schneider, E; Weise, D; El Hajj, N; Tresch, A; Seidmann, L; Coerdt, W; Muller, AM; Zechner, U; Haaf, T,期刊:American Journal of Pathology, 页码:1084-1090 , 文章类型: Article,,卷期:2010年176-3]
- Imprinted genes play an important role in fetal and placental development. Using quantitative bisulfite pyrosequencing assays, we determined the DNA methylation levels at two paternally methylated (H19 and MEG3) and four...
- Dermal Collagen and Lipid Deposition Correlate with Tissue Swelling and Hydraulic Conductivity in Murine Primary Lymphedema
[作者:Rutkowski, JM; Markhus, CE; Gyenge, CC; Alitalo, K; Wiig, H; Swartz, MA,期刊:American Journal of Pathology, 页码:1122-1129 , 文章类型: Article,,卷期:2010年176-3]
- Primary lymphedema is a congenital pathology of dysfunctional lymphatic drainage characterized by swelling of the limbs, thickening of the dermis, and fluid and lipid accumulation in the underlying tissue. Two mouse mode...
- Role of MRP4 (ABCC4) in Platelet Adenine Nucleotide-Storage Evidence from Patients with Delta-Storage Pool Deficiencies
[作者:Jedlitschky, G; Cattaneo, M; Lubenow, LE; Rosskopf, D; Lecchi, A; Artoni, A; Motta, G; Niessen, J; Kroemer, HK; Greinacher, A,期刊:American Journal of Pathology, 页码:1097-1103 , 文章类型: Article,,卷期:2010年176-3]
- We previously showed that die MRP4 (ABCC4) transporter is expressed in human platelet delta-granules, and may he involved in ADP transport. We now demonstrate by immunoblotting and immunofluorescence microscopy that plat...
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