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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共11条记录   Alzheimer's disease amyloid hypothesis at crossroads: where do we go from here? [作者：Saxena, U,期刊：Expert Opinion on Therapeutic Targets, 页码：1273-1277 , 文章类型： Editorial Material，,卷期：2010年14-12] Alzheimer's disease has been the focus of several drug discovery approaches by the pharmaceutical industry. Four drug candidates coming out of such efforts have recently failed in late-stage clinical trials for lack of e... Antiphospholipid syndrome: long-time research on pathogenic mechanisms has finally lead to new therapeutic strategies [作者：Cervera, R; Espinosa, G,期刊：Expert Opinion on Therapeutic Targets, 页码：1279-1282 , 文章类型： Editorial Material，,卷期：2010年14-12] The antiphospholipid syndrome is characterized by the presence of arterial or venous thrombosis or recurrent miscarriages in a patient with positive laboratory tests for antiphospholipid antibodies (anticardiolipin antib... Short and long term anti-inflammatory effects of bosentan therapy in patients with pulmonary arterial hypertension: relation to clinical and hemodynamic responses [作者：Karavolias, GK; Georgiadou, P; Gkouziouta, A; Kariofillis, P; Karabela, G; Tsiapras, D; Sbarouni, E; Chaidaroglou, A; Degiannis, D; Adamopoulos, S; Voudris, V,期刊：Expert Opinion on Therapeutic Targets, 页码：1283-1289 , 文章类型： Article，,卷期：2010年14-12] Objective: We sought to investigate the short-and long-term effects of bosentan therapy on endothelial, inflammatory and fibrotic markers in patients with pulmonary arterial hypertension (PAH) and the relation to clinica... New therapeutic targets for the antiphospholipid syndrome [作者：Pericleous, C; Ioannou, Y,期刊：Expert Opinion on Therapeutic Targets, 页码：1291-1299 , 文章类型： Review，,卷期：2010年14-12] Importance of the field: The antiphospholipid syndrome (APS) is an autoimmune condition whereby pathogenic antiphospholipid antibodies (aPL) cause vascular thrombosis and/or recurrent miscarriage, and carries a high burd... Oxidative pathways as a drug target for the treatment of autism [作者：Villagonzalo, KA; Dodd, S; Dean, O; Gray, K; Tonge, B; Berk, M,期刊：Expert Opinion on Therapeutic Targets, 页码：1301-1310 , 文章类型： Review，,卷期：2010年14-12] Importance of the field: Autism is a severe, pervasive developmental disorder, the aetiology of which is poorly understood. Current pharmacological treatment options for autism are often focused on addressing comorbid be... Inhibition of aggregate formation as therapeutic target in protein misfolding diseases: effect of tetracycline and trehalose [作者：Sirangelo, I; Irace, G,期刊：Expert Opinion on Therapeutic Targets, 页码：1311-1321 , 文章类型： Review，,卷期：2010年14-12] Importance of the field: The identification of molecules that inhibit protein deposition or reverse fibril formation could open new strategies for therapeutic intervention in misfolding diseases. Numerous compounds have ... Mitogen-activated protein kinase phosphatase-1-a potential therapeutic target in metabolic disease [作者：Flach, RJR; Bennett, AM,期刊：Expert Opinion on Therapeutic Targets, 页码：1323-1332 , 文章类型： Review，,卷期：2010年14-12] Importance of the field: Metabolic disease, which is associated with obesity and cardiovascular disease, is a worldwide epidemic. There continues to be a tremendous effort towards the development of therapies to curtail ... The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease [作者：Gatenby, VK; Kearney, MT,期刊：Expert Opinion on Therapeutic Targets, 页码：1333-1342 , 文章类型： Review，,卷期：2010年14-12] Importance of the field: The insulin-resistant conditions of type 2 diabetes mellitus (T2DM) and obesity are a major cause of cardiovascular disease on a global scale. These disorders are not only a cause of ill health b... 14-3-3 zeta as a prognostic marker and therapeutic target for cancer [作者：Neal, CL; Yu, DH,期刊：Expert Opinion on Therapeutic Targets, 页码：1343-1354 , 文章类型： Review，,卷期：2010年14-12] Importance of the field: The ubiquitously expressed 14-3-3 zeta protein is involved in numerous important cellular pathways involved in cancer. Recent research suggests 14-3-3 zeta may play a central role regulating mult... New drug targets in Kaposi sarcoma [作者：Sullivan, RJ; Pantanowitz, L,期刊：Expert Opinion on Therapeutic Targets, 页码：1355-1366 , 文章类型： Review，,卷期：2010年14-12] Importance of the field: Kaposi sarcoma (KS) occurs as a result of Kaposi sarcoma-associated herpesvirus (KSHV) infection, typically in the context of an immunodeficient state such as coinfection with HIV or transplantat... Immunoregulatory actions of polysaccharides from Chinese herbal medicine [作者：Jiang, MH; Zhu, LA; Jiang, JG,期刊：Expert Opinion on Therapeutic Targets, 页码：1367-1402 , 文章类型： Review，,卷期：2010年14-12] Importance of the field: Polysaccharides, one of main classes of bioactive substances from Chinese herbal medicine (CHM), have been indicated to have wide pharmacological activities, especially broad immunomodulatory and...