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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共8条记录   COX-2 expression in human breast carcinomas: correlation with clinicopathological features and prognostic molecular markers [作者：Miglietta, A; Toselli, M; Ravarino, N; Vencia, W; Chiecchio, A; Bozzo, F; Motta, M; Torchio, B; Bocca, C,期刊：Expert Opinion on Therapeutic Targets, 页码：655-664 , 文章类型： Article，,卷期：2010年14-7] Objective: COX-2 is implicated in carcinogenesis and tumour progression in many cancers, including breast cancer. Recently, it has been reported that human breast carcinomas aberrantly express COX-2, and that raised tiss... HtrA proteins as targets in therapy of cancer and other diseases [作者：Zurawa-Janicka, D; Skorko-Glonek, J; Lipinska, B,期刊：Expert Opinion on Therapeutic Targets, 页码：665-679 , 文章类型： Review，,卷期：2010年14-7] Importance of the field: The HtrA family proteins are serine proteases that are involved in important physiological processes, including maintenance of mitochondrial homeostasis, apoptosis and cell signaling. They are in... Gap junctions and connexins as therapeutic targets in cancer [作者：Kandouz, M; Batist, G,期刊：Expert Opinion on Therapeutic Targets, 页码：681-692 , 文章类型： Review，,卷期：2010年14-7] Importance of the field: Connexins (Cxs) and gap junctional intercellular communications (GJICs) play roles in cancer development, growth and metastasis. Experimental studies suggest that targeting Cxs may be a novel tec... Non-cell-autonomous signaling by Shh in tumors: challenges and opportunities for therapeutic targets [作者：Bijlsma, MF; Roelink, H,期刊：Expert Opinion on Therapeutic Targets, 页码：693-702 , 文章类型： Review，,卷期：2010年14-7] Importance of the field: The Hedgehog (Hh) pathway is required during many developmental events; in adults the Hedgehog pathway is involved in the maintenance of several stem cell niches. It is therefore not surprising t... PAK1 as a therapeutic target [作者：Kichina, JV; Goc, A; Al-Husein, B; Somanath, PR; Kandel, ES,期刊：Expert Opinion on Therapeutic Targets, 页码：703-725 , 文章类型： Review，,卷期：2010年14-7] Importance of the field: P21-activated kinases (PAKs) are involved in multiple signal transduction pathways in mammalian cells. PAKs, and PAK1 in particular, play a role in such disorders as cancer, mental retardation an... SHIP2 and its involvement in various diseases [作者：Suwa, A; Kurama, T; Shimokawa, T,期刊：Expert Opinion on Therapeutic Targets, 页码：727-737 , 文章类型： Review，,卷期：2010年14-7] Importance of the field: Inositol polyphosphate 5-phosphatase (SHIP2) is an important negative regulator of intracellular phosphatidylinositol phosphate, a key second messenger of various intracellular signaling pathways... Glycobiology of the Leishmania parasite and emerging targets for antileishmanial drug discovery [作者：Chandra, S; Ruhela, D; Deb, A; Vishwakarma, RA,期刊：Expert Opinion on Therapeutic Targets, 页码：739-757 , 文章类型： Review，,卷期：2010年14-7] Importance of the field: Parasitic diseases that pose a threat to human life include leishmaniasis - caused by protozoa of Leishmania species. Existing drugs have limitations due to deleterious side effects like teratoge... Targeting IL-23 in human diseases [作者：D'Elios, MM; Del Prete, G; Amedei, A,期刊：Expert Opinion on Therapeutic Targets, 页码：759-774 , 文章类型： Review，,卷期：2010年14-7] Importance of the field: IL-23 is one of the most intriguing cytokine for its many immunological functions, which are the basis of its important role in host defense but also of its possible contribution to the pathogene...