- Glycomics Hits the Big Time
[作者:Hart, GW; Copeland, RJ,期刊:Cell, 页码:672-676 , 文章类型: Article,,卷期:2010年143-5]
- Cells run on carbohydrates. Glycans, sequences of carbohydrates conjugated to proteins and lipids, are arguably the most abundant and structurally diverse class of molecules in nature. Recent advances in glycomics reveal...
- Ubiquitin: Same Molecule, Different Degradation Pathways
[作者:Clague, MJ; Urbe, S,期刊:Cell, 页码:682-685 , 文章类型: Review,,卷期:2010年143-5]
- Ubiquitin is a common demoninator in the targeting of substrates to all three major protein degradation pathways in mammalian cells: the proteasome, the lysosome, and the autophagosome. The factors that direct a substrat...
- Modifications of Small RNAs and Their Associated Proteins
[作者:Kim, YK; Heo, I; Kim, VN,期刊:Cell, 页码:703-709 , 文章类型: Review,,卷期:2010年143-5]
- Small regulatory RNAs and their associated proteins are subject to diverse modifications that can impinge on their abundance and function. Some of the modifications are under the influence of cellular signaling, thus con...
- The ER UDPase ENTPD5 Promotes Protein N-Glycosylation, the Warburg Effect, and Proliferation in the PTEN Pathway
[作者:Fang, M; Shen, ZR; Huang, S; Zhao, LP; Chen, S; Mak, TW; Wang, XD,期刊:Cell, 页码:711-724 , 文章类型: Article,,卷期:2010年143-5]
- PI3K and PTEN lipid phosphatase control the level of cellular phosphatidylinositol (3,4,5)-trisphosphate, an activator of AKT kinases that promotes cell growth and survival. Mutations activating AKT are commonly observed...
- Stepwise Histone Replacement by SWR1 Requires Dual Activation with Histone H2A.Z and Canonical Nucleosome
[作者:Luk, E; Ranjan, A; FitzGerald, PC; Mizuguchi, G; Huang, Y; Wei, D; Wu, C,期刊:Cell, 页码:725-736 , 文章类型: Article,,卷期:2010年143-5]
- Histone variant H2A.Z-containing nucleosomes are incorporated at most eukaryotic promoters. This incorporation is mediated by the conserved SWR1 complex, which replaces histone H2A in canonical nucleosomes with H2A.Z in ...
- Sororin Mediates Sister Chromatid Cohesion by Antagonizing Wapl
[作者:Nishiyama, T; Ladurner, R; Schmitz, J; Kreidl, E; Schleiffer, A; Bhaskara, V; Bando, M; Shirahige, K; Hyman, AA; Mechtler, K; Peters, JM,期刊:Cell, 页码:737-749 , 文章类型: Article,,卷期:2010年143-5]
- Sister chromatid cohesion is essential for chromosome segregation and is mediated by cohesin bound to DNA. Cohesin-DNA interactions can be reversed by the cohesion-associated protein Wapl, whereas a stably DNA-bound form...
- Sequence-Dependent Sorting of Recycling Proteins by Actin-Stabilized Endosomal Microdomains
[作者:Puthenveedu, MA; Lauffer, B; Temkin, P; Vistein, R; Carlton, P; Thorn, K; Taunton, J; Weiner, OD; Parton, RG; von Zastrow, M,期刊:Cell, 页码:761-773 , 文章类型: Article,,卷期:2010年143-5]
- The functional consequences of signaling receptor endocytosis are determined by the endosomal sorting of receptors between degradation and recycling pathways. How receptors recycle efficiently, in a sequence-dependent ma...
- Mechanisms Determining the Morphology of the Peripheral ER
[作者:Shibata, Y; Shemesh, T; Prinz, WA; Palazzo, AF; Kozlov, MM; Rapoport, TA,期刊:Cell, 页码:774-788 , 文章类型: Article,,卷期:2010年143-5]
- The endoplasmic reticulum (ER) consists of the nuclear envelope and a peripheral network of tubules and membrane sheets. The tubules are shaped by the curvature-stabilizing proteins reticulons and DP1/Yop1p, but how the ...
- Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue
[作者:Doitsh, G; Cavrois, M; Lassen, KG; Zepeda, O; Yang, ZY; Santiago, ML; Hebbeler, AM; Greene, WC,期刊:Cell, 页码:789-801 , 文章类型: Article,,卷期:2010年143-5]
- The mechanism by which CD4 T cells are depleted in HIV-infected hosts remains poorly understood. In ex vivo cultures of human tonsil tissue, CD4 T cells undergo a pronounced cytopathic response following HIV infection. S...
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