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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   Protein-Peptide Interactions Adopt the Same Structural Motifs as Monomeric Protein Folds [作者：Vanhee, P; Stricher, F; Baeten, L; Verschueren, E; Lenaerts, T; Serrano, L; Rousseau, F; Schymkowitz, J,期刊：Structure, 页码：1128-1136 , 文章类型： Article，,卷期：2009年17-8] We compared the modes of interaction between protein-peptide interfaces and those observed within monomeric proteins and found surprisingly few differences. Over 65% of 731 protein-peptide interfaces could be reconstruct... A Tetrahedral Transition State at the Active Sites of the 20S Proteasome Is Coupled to Opening of the alpha-Ring Channel [作者：Smulski, PA; Hochstrasser, M; Gaczynska, M,期刊：Structure, 页码：1137-1147 , 文章类型： Article，,卷期：2009年17-8] Intrinsic conformational transitions contribute to the catalytic action of many enzymes. Here we use a single-molecule approach to demonstrate how such transitions are linked to the catalytic sites of the eukaryotic prot... The Origin of Allosteric Functional Modulation: Multiple Pre-existing Pathways [作者：del Sol, A; Tsai, CJ; Ma, BY; Nussinov, R,期刊：Structure, 页码：1042-1050 , 文章类型： Review，,卷期：2009年17-8] Although allostery draws increasing attention, not much is known about allosteric mechanisms. Here we argue that in all proteins, allosteric signals transmit through multiple, pre-existing pathways; which pathways domina... The CATH Hierarchy Revisited-Structural Divergence in Domain Superfamilies and the Continuity of Fold Space [作者：Cuff, A; Redfern, OC; Greene, L; Sillitoe, I; Lewis, T; Dibley, M; Reid, A; Pearl, F; Dallman, T; Todd, A; Garratt, R; Thornton, J; Orengo, C,期刊：Structure, 页码：1051-1062 , 文章类型： Article，,卷期：2009年17-8] This paper explores the structural continuum in CATH and the extent to which superfamilies adopt distinct folds. Although most superfamilies are structurally conserved, in some of the most highly populated superfamilies ... Multimeric Options for the Auto-Activation of the Saccharomyces cerevisiae FAS Type I Megasynthase [作者：Johansson, P; Mulinacci, B; Koestler, C; Vollrath, R; Oesterhelt, D; Grininger, M,期刊：Structure, 页码：1063-1074 , 文章类型： Article，,卷期：2009年17-8] The fungal type I fatty acid synthase (FAS) is a 2.6 MDa multienzyme complex, catalyzing all necessary steps for the synthesis of long acyl chains. To be catalytically competent, the FAS must be activated by a posttransl... Characterizing the Initial Encounter Complex in Cadherin Adhesion [作者：Sivasankar, S; Zhang, YX; Nelson, WJ; Chu, S,期刊：Structure, 页码：1075-1081 , 文章类型： Article，,卷期：2009年17-8] Cadherins are Ca2+-dependent cell-cell adhesion proteins with an extracellular region of five domains (EC1 to EC5). Adhesion is mediated by "strand swapping" of a conserved tryptophan residue in position 2 between EC1 do... The Structure of the Scaffold Nucleoporin Nup120 Reveals a New and Unexpected Domain Architecture [作者：Leksa, NC; Brohawn, SG; Schwartz, TU,期刊：Structure, 页码：1082-1091 , 文章类型： Article，,卷期：2009年17-8] Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs), enormous protein assemblies residing in circular openings in the nuclear envelope. The NPC is modular, with transient and stable components. The s... Structural Determinants of Transmembrane Helical Proteins [作者：Harrington, SE; Ben-Tal, N,期刊：Structure, 页码：1092-1103 , 文章类型： Article，,卷期：2009年17-8] We identify a structural feature of transmembrane helical proteins that restricts their conformational space and suggests a new way of understanding the construction and stability of their native states. We show that fiv... Structural Analysis of the GGDEF-EAL Domain-Containing c-di-GMP Receptor FimX [作者：Navarro, MVAS; De, N; Bae, N; Wang, Q; Sondermann, H,期刊：Structure, 页码：1104-1116 , 文章类型： Article，,卷期：2009年17-8] Bacterial pathogenesis involves social behavior including biofilm formation and swarming, processes that are regulated by the bacterially unique second messenger cyclic di-GMP (c-di-GMP). Diguanylate cyclases containing ... A Surface Loop Directs Conformational Switching of a Lipoyl Domain Between a Folded and a Novel Misfolded Structure [作者：Stott, KM; Yusof, AM; Perham, RN; Jones, DD,期刊：Structure, 页码：1117-1127 , 文章类型： Article，,卷期：2009年17-8] A prominent surface loop links the first two 0 strands of the lipoyl domain (E2plip) from the pyruvate dehydrogenase multienzyme complex of Escherichia coli. We show here that shortening this loop by two residues generat...