- Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody
[作者：Ganesan, R; Eigenbrot, C; Wu, Y; Liang, WC; Shia, S; Lipari, MT; Kirchhofer, D,期刊：Structure, 页码：1614-1624 , 文章类型： Article，,卷期：2009年17-12]
- Recent structural studies have outlined the mechanism of protease inhibition by active site-directed antibodies. However, the molecular basis of allosteric inhibition by antibodies has been elusive. Here we report the 2....
- Structure of HIV-1 Reverse Transcriptase with the Inhibitor beta-Thujaplicinol Bound at the RNase H Active Site
[作者：Himmel, DM; Maegley, KA; Pauly, TA; Bauman, JD; Das, K; Dharia, C; Clark, AD; Ryan, K; Hickey, MJ; Love, RA; Hughes, SH; Bergqvist, S; Arnold, E,期刊：Structure, 页码：1625-1635 , 文章类型： Article，,卷期：2009年17-12]
- Novel inhibitors are needed to counteract the rapid emergence of drug-resistant HIV variants. HIV-1 reverse transcriptase (RT) has both DNA polymerase and RNase H (RNH) enzymatic activities, but approved drugs that inhib...
- Structure and Mechanism of the Lincosamide Antibiotic Adenylyltransferase LinB
[作者：Morar, M; Bhullar, K; Hughes, DW; Junop, M; Wright, GD,期刊：Structure, 页码：1649-1659 , 文章类型： Article，,卷期：2009年17-12]
- Lincosamides make up an important class of antibiotics used against a wide range of pathogens, including methicillin-resistant Staphylococcus aureus. Predictably, lincosamide-resistant microorganisms have emerged with an...
- A Role for a Specific Cholesterol Interaction in Stabilizing the Apo Configuration of the Human A(2A) Adenosine Receptor
[作者：Lyman, E; Higgs, C; Kim, B; Lupyan, D; Shelleys, JC; Farid, R; Voth, GA,期刊：Structure, 页码：1660-1668 , 文章类型： Article，,卷期：2009年17-12]
- The function of G-protein-coupled receptors is tightly modulated by the lipid environment. Long-timescale molecular dynamics simulations (totaling similar to 3 mu s) of the A(2A) receptor in cholesterol-free bilayers, wi...
- Crystallographic Insight into Collagen Recognition by Discoidin Domain Receptor 2
[作者：Carafoli, F; Bihan, D; Stathopoulos, S; Konitsiotis, AD; Kvansakul, M; Farndale, RW; Leitinger, B; Hohenester, E,期刊：Structure, 页码：1573-1581 , 文章类型： Article，,卷期：2009年17-12]
- The discoidin domain receptors, DDR1 and DDR2, are widely expressed receptor tyrosine kinases that are activated by triple-helical collagen. They control important aspects of cell behavior and are dysregulated in several...
- Non-Native Interactions Are Critical for Mechanical Strength in PKD Domains
[作者：Forman, JR; Yew, ZT; Qamar, S; Sandford, RN; Paci, E; Clarke, J,期刊：Structure, 页码：1582-1590 , 文章类型： Article，,卷期：2009年17-12]
- Experimental observation has led to the commonly held view that native state protein topology is the principle determinant of mechanical strength. However, the PKD domains of polycystin-1 challenge this assumption: they ...
- Comprehensive Molecular Structure of the Eukaryotic Ribosome
[作者：Taylor, DJ; Devkota, B; Huang, AD; Topf, M; Narayanan, E; Sali, A; Harvey, SC; Frank, J,期刊：Structure, 页码：1591-1604 , 文章类型： Article，,卷期：2009年17-12]
- Despite the emergence of a large number of X-ray crystallographic models of the bacterial 70S ribosome over the past decade, an accurate atomic model of the eukaryotic 80S ribosome is still not available. Eukaryotic ribo...
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