- KTN (RCK) Domains Regulate K+ Channels and Transporters by Controlling the Dimer-Hinge Conformation
[作者：Roosild, TP; Castronovo, S; Miller, S; Li, C; Rasmussen, T; Bartlett, W; Gunasekera, B; Choe, S; Booth, IR,期刊：Structure, 页码：893-903 , 文章类型： Article，,卷期：2009年17-6]
- KTN (RCK) domains are nucleotide-binding folds that form the cytoplasmic regulatory complexes of various K+ channels and transporters. The mechanisms these proteins use to control their transmembrane pore-forming counter...
- Structural Basis for DNase Activity of a Conserved Protein Implicated in CRISPR-Mediated Genome Defense
[作者：Wiedenheft, B; Zhou, KH; Jinek, M; Coyle, SM; Ma, W; Doudna, JA,期刊：Structure, 页码：904-912 , 文章类型： Article，,卷期：2009年17-6]
- Acquired immunity in prokaryotes is achieved by integrating short fragments of foreign nucleic acids into clustered regularly interspaced short palindromic repeats (CRISPRs). This nucleic acid-based immune system is medi...
- The P22 Tail Machine at Subnanometer Resolution Reveals the Architecture of an Infection Conduit
[作者：Lander, GC; Khayat, R; Li, R; Prevelige, PE; Potter, CS; Carragher, B; Johnson, JE,期刊：Structure, 页码：789-799 , 文章类型： Article，,卷期：2009年17-6]
- The portal channel is a key component in the life cycle of bacteriophages and herpesviruses. The bacteriophage P22 portal is a 1 megadalton dodecameric oligomer of gp1 that plays key roles in capsid assembly, DNA packagi...
- The Structure of Gene Product 6 of Bacteriophage T4, the Hinge-Pin of the Baseplate
[作者：Aksyuk, AA; Leiman, PG; Shneider, MM; Mesyanzhinov, VV; Rossmann, MG,期刊：Structure, 页码：800-808 , 文章类型： Article，,卷期：2009年17-6]
- The baseplate of bacteriophage T4 is a multicomponent protein complex, which controls phage attachment to the host. It assembles from six wedges and a central hub. During infection the baseplate undergoes a large conform...
- Distinct Binding Modes of Two Epitopes in Gab2 that Interact with the SH3C Domain of Grb2
[作者：Harkiolaki, M; Tsirka, T; Lewitzky, M; Simister, PC; Joshi, D; Bird, LE; Jones, EY; O'Reilly, N; Feller, SM,期刊：Structure, 页码：809-822 , 文章类型： Article，,卷期：2009年17-6]
- Grb2 and Gab2 form a complex implicated in normal cell signaling and cancer development. Binding of the Grb2SH3C domain to Gab2 is essential for the interaction, but molecular details remained undefined. Using peptide ar...
- A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A
[作者：Yu, LPC; Xiang, S; Lasso, G; Gil, D; Valle, M; Tong, L,期刊：Structure, 页码：823-832 , 文章类型： Article，,卷期：2009年17-6]
- Pyruvate carboxylase (PC) is a conserved metabolic enzyme with important cellular functions. We report crystallographic and cryo-electron microscopy (EM) studies of Staphylococcus aureus PC (SaPC) in complex with acetyl-...
- A Crescent-Shaped ALIX Dimer Targets ESCRT-III CHMP4 Filaments
[作者：Pires, R; Hartlieb, B; Signor, L; Schoehn, G; Lata, S; Roessle, M; Moriscot, C; Popov, S; Hinz, A; Jamin, M; Boyer, V; Sadoul, R; Forest, E; Svergun, DI; Gottlinger, HG; Weissenhorn, W,期刊：Structure, 页码：843-856 , 文章类型： Article，,卷期：2009年17-6]
- ALIX recruits ESCRT-III CHMP4 and is involved in membrane remodeling during endosomal receptor sorting, budding of some enveloped viruses, and cytokinesis. We show that ALIX dimerizes via the middle domain (ALIX(-V)) in ...
- PSI-2: Structural Genomics to Cover Protein Domain Family Space
[作者：Dessailly, BH; Nair, R; Jaroszewski, L; Fajardo, JE; Kouranov, A; Lee, D; Fiser, A; Godzik, A; Rost, B; Orengo, C,期刊：Structure, 页码：869-881 , 文章类型： Article，,卷期：2009年17-6]
- One major objective of structural genomics efforts, including the NIH-funded Protein Structure Initiative (PSI), has been to increase the structural coverage of protein sequence space. Here, we present the target selecti...
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