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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共17条记录   Structural Basis for Recruitment of Rab6-Interacting Protein 1 to Golgi via a RUN Domain [作者：Recacha, R; Boulet, A; Jollivet, F; Monier, S; Houdusse, A; Goud, B; Khan, AR,期刊：Structure, 页码：21-30 , 文章类型： Article，,卷期：2009年17-1] Small GTPase Rab6 regulates vesicle trafficking at the level of Golgi via recruitment of numerous and unrelated effectors. The crystal structure of Ra-b6a(GTP) in complex with a 378-residue internal fragment of the effec... Symmetrical Modularity of the COP9 Signalosome Complex Suggests its Multifunctionality [作者：Sharon, M; Mao, HB; Erba, EB; Stephens, E; Zheng, N; Robinson, CV,期刊：Structure, 页码：31-40 , 文章类型： Article，,卷期：2009年17-1] The COP9 signalosome (CSN) is an eight-subunit protein complex that is found in all eukaryotes. Accumulating evidence indicates its diverse biological functions that are often linked to ubiquitin-mediated proteolysis. He... Differences in Flexibility Underlie Functional Differences in the Ras Activators Son of Sevenless and Ras Guanine Nucleotide Releasing Factor 1 [作者：Freedman, TS; Sondermann, H; Kuchment, O; Friedland, GD; Kortemme, T; Kuriyan, J,期刊：Structure, 页码：41-53 , 文章类型： Article，,卷期：2009年17-1] The Ras-specific nucleotide exchange factor Son of sevenless (Sos) is inactive without Ras bound to a distal allosteric site. In contrast, the catalytic domain of Ras guanine nucleotide releasing factor 1 (RasGRF1) is ac... Structural and Biophysical Studies of the Human IL-7/IL-7R alpha Complex [作者：McElroy, CA; Dohm, JA; Walsh, STR,期刊：Structure, 页码：54-65 , 文章类型： Article，,卷期：2009年17-1] IL-7 and IL-7R alpha bind the gamma(c) receptor, forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells. We report that the IL-7R alpha ectodomain uses glycosy... The Evolutionary Mechanics of Domain Organization in Proteomes and the Rise of Modularity in the Protein World [作者：Wang, ML; Caetano-Anolles, G,期刊：Structure, 页码：66-78 , 文章类型： Article，,卷期：2009年17-1] Protein domains are compact evolutionary units of structure and function that usually combine in proteins to produce complex domain arrangements. In order to study their evolution, we reconstructed genome-based phylogene... Structure and Membrane Interaction of Myristoylated ARF1 [作者：Liu, YZ; Kahn, RA; Prestegard, JH,期刊：Structure, 页码：79-87 , 文章类型： Article，,卷期：2009年17-1] ADP-ribosylation factors (ARFs) are small (21 kDa), monomeric GTPases that are important regulators of membrane traffic. When membrane bound, they recruit soluble adaptors to membranes and trigger the assembly of coating... An Atomistic View to the Gas Phase Proteome [作者：Meyer, T; de la Cruz, X; Orozco, M,期刊：Structure, 页码：88-95 , 文章类型： Article，,卷期：2009年17-1] Extended all-atom molecular dynamics simulations on all protein metafolds have been performed to obtain a complete picture of the gas phase proteome. The structural atlas of the gas phase proteome obtained here shows an ... The Structure of the MAP2K MEK6 Reveals an Autoinhibitory Dimer [作者：Min, XS; Akella, R; He, HX; Humphreys, JM; Tsutakawa, SE; Lee, SJ; Tainer, JA; Cobb, MH; Goldsmith, EJ,期刊：Structure, 页码：96-104 , 文章类型： Article，,卷期：2009年17-1] MAP2Ks are dual-specificity protein kinases functioning at the center of three-tiered MAP kinase modules. The structure of the kinase domain of the MAP2K MEK6 with phosphorylation site mimetic aspartic acid mutations (ME... The Crystal Structure of the N-Terminal Region of BUB1 Provides Insight into the Mechanism of BUB1 Recruitment to Kinetochores [作者：Bolanos-Garcia, VM; Kiyomitsu, T; D'Arcy, S; Chirgadze, DY; Grossmann, JG; Matak-Vinkovic, D; Venkitaraman, AR; Yanagida, M; Robinson, CV; Blundell, TL,期刊：Structure, 页码：105-116 , 文章类型： Article，,卷期：2009年17-1] The interaction of the central mitotic checkpoint component BUB1 with the mitotic kinetochore protein Blinkin is required for the kinetochore localization and function of BUB1 in the mitotic spindle assembly checkpoin... The Structure of Phosphorylase Kinase Holoenzyme at 9.9 angstrom Resolution and Location of the Catalytic Subunit and the Substrate Glycogen Phosphorylase [作者：Venien-Bryan, C; Jonic, S; Skamnaki, V; Brown, N; Bischler, N; Oikonomakos, NG; Boisset, N; Johnson, LN,期刊：Structure, 页码：117-127 , 文章类型： Article，,卷期：2009年17-1] Phosphorylase kinase (PhK) coordinates hormonal and neuronal signals to initiate the breakdown of glycogen. The enzyme catalyzes the phosphorylation of inactive glycogen phosphorylase b (GPb), resulting in the formation ... Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site [作者：Scheeff, ED; Eswaran, J; Bunkoczi, G; Knapp, S; Manning, G,期刊：Structure, 页码：128-138 , 文章类型： Article，,卷期：2009年17-1] About 10% of all protein kinases are predicted to be enzymatically inactive pseudokinases, but the structural details of kinase inactivation have remained unclear. We present the first structure of a pseudokinase, VRK3, ... ROP2 from Toxoplasma gondii: A Virulence Factor with a Protein-Kinase Fold and No Enzymatic Activity [作者：Labesse, G; Gelin, M; Bessin, Y; Lebrun, M; Papoin, J; Cerdan, R; Arold, ST; Dubremetz, JF,期刊：Structure, 页码：139-146 , 文章类型： Article，,卷期：2009年17-1] The ROP2 protein and its paralogs are important virulence factors secreted into the host cell by the parasite Toxoplasma gondii. Here we describe the crystal structure of a large and soluble domain of mature ROP2, repres... On the Structural Model of the COP9 Signalosome [作者：Wei, N,期刊：Structure, 页码：1-2 , 文章类型： Editorial Material，,卷期：2009年17-1] In this issue, Sharon et al. (2009) determined the subunit organization of the COP9 signalosome by mass spectrometry. The structural features uncovered from this analysis are consistent with the multifunctionality of the... Journey to the Ends of the Arf [作者：Gruschus, JM; Chen, PW; Luo, RB; Randazzo, PA,期刊：Structure, 页码：2-4 , 文章类型： Editorial Material，,卷期：2009年17-1] In this issue, Liu et al. (2009) used NMR to provide the most complete information to date on the structure of Arf1 and the role of myristate in GDP/GTP exchange. Unanticipated details lead to speculation about functions... Pseudokinases: Functional Insights Gleaned from Structure [作者：Kornev, AP; Taylor, SS,期刊：Structure, 页码：5-7 , 文章类型： Editorial Material，,卷期：2009年17-1] Pseudokinases are an intriguing group inside the large protein kinase family. Lacking the highly conserved catalytic machinery, they can be still important for multiple functions in living cells. The structures of two ps... Discovery of New GPCR Biology: One Receptor Structure at a Time [作者：Hanson, MA; Stevens, RC,期刊：Structure, 页码：8-14 , 文章类型： Review，,卷期：2009年17-1] G-protein-coupled receptors (GPCRs) are the largest family of proteins in the human genome. Within the last year, we have witnessed a relative explosion in the amount of structural information available for the GPCR fami...