- 1Alpha,25-dihydroxyvitamin D(3) Induces de novo E-cadherin Expression in Triple-negative Breast Cancer Cells by CDH1-promoter Demethylation
[作者:Lopes, N; Carvalho, J; Duraes, C; Sousa, B; Gomes, M; Costa, JL; Oliveira, C; Paredes, J; Schmitt, F,期刊:Anticancer Research, 页码:249-257 , 文章类型: Article,,卷期:2012年32-SI]
- Background: The triple-negative subgroup of breast cancer includes a cluster of tumors exhibiting low E-cadherin expression (metaplastic carcinomas). In several cancer models, lalpha,25-dihydroxyvitamin D(3) (1 alpha,25(...
- Determination of 1,25-dihydroxyvitamin D Concentrations in Human Colon Tissues and Matched Serum Samples
[作者:Wagner, D; Dias, AG; Schnabl, K; Van Der Kwast, T; Vieth, R,期刊:Anticancer Research, 页码:259-263 , 文章类型: Article,,卷期:2012年32-SI]
- Background: A novel method to measure 1,25-dihydroxyvitamin D (1,25(OH)(2)D) in human tissue was developed and validated. The objectives of this study were to determine whether 1,25(OH)(2)D is present in human colon tiss...
- Serum 25-Hydroxyvitamin D Levels in Patients with Vulvar Cancer
[作者:Salehin, D; Haugk, C; Thill, M; Cordes, T; Hornung, D; Abu-Hechle, A; Hemmerlein, B; Friedrich, M,期刊:Anticancer Research, 页码:265-270 , 文章类型: Article,,卷期:2012年32-SI]
- Background: The anticarcinogenic potential of vitamin D 25(OH)D has been attributed to the inhibition of proliferation of cells from different carcinomas. Reduced serum levels of 25(OH)D are associated with an increased ...
- The First Genome-wide View of Vitamin D Receptor Locations and Their Mechanistic Implications
[作者:Carlberg, C; Seuter, S; Heikkinen, S,期刊:Anticancer Research, 页码:271-282 , 文章类型: Review,,卷期:2012年32-SI]
- The transcription factor vitamin D receptor (VDR) is the nuclear sensor for the biologically most active metabolite of vitamin D, 1 alpha,25-dihydroxyvitamin D(3) (1 alpha,25(OH)(2)D(3)). The physiological actions of the...
- Vitamin D Receptor Expression in Patients with Vulvar Cancer
[作者:Salehin, D; Haugk, C; Thill, M; Cordes, T; William, M; Hemmerlein, B; Friedrich, M,期刊:Anticancer Research, 页码:283-289 , 文章类型: Article,,卷期:2012年32-SI]
- The anticarcinogenic potential of vitamin D is attributed to antiproliferative and prodtfferentiative effects on cells for a wide variety of carcinomas. The biological effects of 1,25(OH)(2)D (calcitriol) are mediated th...
- The Roles of Cytochrome P450 Enzymes in Prostate Cancer Development and Treatment
[作者:Chen, TC; Sakaki, T; Yamamoto, K; Kittaka, A,期刊:Anticancer Research, 页码:291-298 , 文章类型: Review,,卷期:2012年32-SI]
- The active form of vitamin D, 1 alpha,25dihydroxyvitamin D [1 alpha,25(OH)(2)D], interacts with vitamin D receptor (VDR) and induces antiproliferative, anti-invasive, proapoptotic and pro-differentiation activities in pr...
- Process Development for the Practical Production of Eldecalcitol by Linear, Convergent and Biomimetic Syntheses
[作者:Kubodera, N; Hatakeyama, S,期刊:Anticancer Research, 页码:303-309 , 文章类型: Article,,卷期:2012年32-SI]
- Eldecalcitol [1 alpha,25-dihydroxy-2 beta-(3-hydroxypropoxy)vitamin D(3)], an analog of calcitriol (1 alpha,25-dihydroxyvitamin D(3)), possesses a hydroxypropoxy substituent at the 2 beta-position of calcitriol. Eldecalc...
- C15-functionalized 16-Ene-1 alpha,25-dihydroxyvitamin D(3) is a New Vitamin D Analog with Unique Biological Properties
[作者:Kumagai, G; Takano, M; Shindo, K; Sawada, D; Saito, N; Saito, H; Kakuda, S; Takagi, KI; Takimoto-Kamimura, M; Takenouchi, K; Chen, TC; Kittaka, A,期刊:Anticancer Research, 页码:311-317 , 文章类型: Article,,卷期:2012年32-SI]
- The Delta(16) structure as a vitamin D analog enhanced vitamin D receptor (VDR) binding affinity and induced significant cell differentiation, whereas its relative calcemic activity was reduced compared to 1 alpha,25-dih...
- The Difference between 14-Epi-previtamin D(3) and 14-Epi-19-norprevitamin D(3): Their Synthesis and Binding Affinity for Human VDR
[作者:Sawada, D; Katayama, T; Tsukuda, Y; Saito, N; Saito, H; Kakuda, S; Takimoto-Kamimura, M; Takenouchi, K; Kittaka, A,期刊:Anticancer Research, 页码:319-326 , 文章类型: Article,,卷期:2012年32-SI]
- The synthesis of 14-epi-1 alpha,25(OH)(2)previtamin D(3), 14-epi-19-nor-1 alpha,25(OH)(2)previtamin D(3), and their 2-substituted analogs is described. The vitamin D receptor (VDR) binding affinity was further evaluated ...
- Association of Genetic Variants of the Vitamin D Receptor (VDR) with Cutaneous Squamous Cell Carcinomas (SCC) and Basal Cell Carcinomas (BCC): A Pilot Study in a German Population
[作者:Kostner, K; Denzer, N; Koreng, M; Reichrath, S; Graber, S; Klein, R; Tilgen, W; Vogt, T; Reichrath, J,期刊:Anticancer Research, 页码:327-333 , 文章类型: Article,,卷期:2012年32-SI]
- Background: Vitamin D receptor (VDR) polymorphisms have important implications for vitamin D signalling and are associated with various malignancies. Patients and Methods: In a German population, the frequency of several...
- Crystal Structure of a Vitamin D(3) Analog, ZK203278, Showing Dissociated Profile
[作者:Rochel, N; Moras, D,期刊:Anticancer Research, 页码:335-339 , 文章类型: Article,,卷期:2012年32-SI]
- The plethora of actions of 1 alpha,25-dihydroxyvitamin D(3), the active form of the seco-steroid hormone vitamin D, in various systems suggested wide clinical applications in treatinents for renal osteodystrophy, osteopo...
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