- The tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells
[作者:Carosella, ED; Gregori, S; LeMaoult, J,期刊:Blood, 页码:6499-6505 , 文章类型: Review,,卷期:2011年118-25]
- Myeloid antigen-presenting cells (APCs), regulatory cells, and the HLA-G molecule are involved in modulating immune responses and promoting tolerance. APCs are known to induce regulatory cells and to express HLA-G as wel...
- Chronic myeloproliferative neoplasms and subsequent cancer risk: a Danish population-based cohort study
[作者:Frederiksen, H; Farkas, DK; Christiansen, CF; Hasselbalch, HC; Sorensen, HT,期刊:Blood, 页码:6515-6520 , 文章类型: Article,,卷期:2011年118-25]
- Patients with chronic myeloproliferative neoplasms, including essential thrombocythemia (ET), polycythemia vera (PV), and chronic myeloid leukemia (CML), are at increased risk of new hematologic malignancies, but their r...
- Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia
[作者:Foa, R; Vitale, A; Vignetti, M; Meloni, G; Guarini, A; De Propris, MS; Elia, L; Paoloni, F; Fazi, P; Cimino, G; Nobile, F; Ferrara, F; Castagnola, C; Sica, S; Leoni, P; Zuffa, E; Fozza, C; Luppi, M; Candoni, A; Iacobucci, I; Soverini, S; Mandelli, F; Martinelli, G; Baccarani, M,期刊:Blood, 页码:6521-6528 , 文章类型: Article,,卷期:2011年118-25]
- Dasatinib is a potent BCR-ABL inhibitor effective in chronic myeloid leukemia and Ph(+) acute lymphoblastic leukemia (ALL) resistant/intolerant to imatinib. In the GIMEMA LAL1205 protocol, patients with newly diagnosed P...
- Bone microstructural changes revealed by high-resolution peripheral quantitative computed tomography imaging and elevated DKK1 and MIP-1 alpha levels in patients with MGUS
[作者:Ng, AC; Khosla, S; Charatcharoenwitthaya, N; Kumar, SK; Achenbach, SJ; Holets, MF; McCready, LK; Melton, LJ; Kyle, RA; Rajkumar, SV; Drake, MT,期刊:Blood, 页码:6529-6534 , 文章类型: Article,,卷期:2011年118-25]
- Recent population-based studies demonstrate an increased fracture risk with monoclonal gammopathy of undetermined significance (MGUS). The etiology of this increased risk remains unclear, however, because areal bone mine...
- Oral arsenic trioxide-based maintenance regimens for first complete remission of acute promyelocytic leukemia: a 10-year follow-up study
[作者:Au, WY; Kumana, CR; Lee, HKK; Lin, SY; Liu, H; Yeung, DYM; Lau, JSM; Kwong, YL,期刊:Blood, 页码:6535-6543 , 文章类型: Article,,卷期:2011年118-25]
- Seventy-six patients with acute promyelocytic leukemia (APL) in first complete remission after induction and consolidation by daunorubicin and cytosine arabinoside received oral arsenic trioxide (As(2)O(3))-based mainten...
- The ability of MLLto bind RUNX1 and methylate H3K4 at PU. 1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations
[作者:Huang, G; Zhao, XH; Wang, L; Elf, S; Xu, H; Zhao, XY; Sashida, G; Zhang, Y; Liu, Y; Lee, J; Menendez, S; Yang, YY; Yan, XM; Zhang, P; Tenen, DG; Osato, M; Hsieh, JJD; Nimer, SD,期刊:Blood, 页码:6544-6552 , 文章类型: Article,,卷期:2011年118-25]
- The mixed-lineage leukemia (MLL) H3K4 methyltransferase protein, and the heterodimeric RUNX1/CBF beta transcription factor complex, are critical for definitive and adult hematopoiesis, and both are frequently targeted in...
- Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells
[作者:Mochizuki-Kashio, M; Mishima, Y; Miyagi, S; Negishi, M; Saraya, A; Konuma, T; Shinga, J; Koseki, H; Iwama, A,期刊:Blood, 页码:6553-6561 , 文章类型: Article,,卷期:2011年118-25]
- Polycomb-group (PcG) proteins are essential regulators of hematopoietic stem cells (HSCs). In contrast to Bmi1, a component of Polycomb repressive complex 1 (PRC1), the role of PRC2 and its components in hematopoiesis re...
- Significant mobilization of both conventional and regulatory T cells with AMD3100
[作者:Kean, LS; Sen, S; Onabajo, O; Singh, K; Robertson, J; Stempora, L; Bonifacino, AC; Metzger, ME; Promislow, DEL; Mattapallil, JJ; Donahue, RE,期刊:Blood, 页码:6580-6590 , 文章类型: Article,,卷期:2011年118-25]
- In this study, we used the rhesus macaque model to determine the impact that AMD3100 has on lymphocyte mobilization, both alone and in combination with G-CSF. Our results indicate that, unlike G-CSF, AMD3100 substantiall...
- Evidence for the divergence of innate and adaptive T-cell precursors before commitment to the alpha beta and gamma delta lineages
[作者:Kisielow, J; Tortola, L; Weber, J; Karjalainen, K; Kopf, M,期刊:Blood, 页码:6591-6600 , 文章类型: Article,,卷期:2011年118-25]
- In addition to adaptive T cells, the thymus supports the development of unconventional T cells such as natural killer T (NKT) and CD8 alpha alpha intraepithelial lymphocytes (IELs), which have innate functional propertie...
- Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia
[作者:Katagiri, T; Sato-Otsubo, A; Kashiwase, K; Morishima, S; Sato, Y; Mori, Y; Kato, M; Sanada, M; Morishima, Y; Hosokawa, K; Sasaki, Y; Ohtake, S; Ogawa, S; Nakao, S,期刊:Blood, 页码:6601-6609 , 文章类型: Article,,卷期:2011年118-25]
- Idiopathic aplastic anemia (AA) is a common cause of acquired BM failure. Although autoimmunity to hematopoietic progenitors is thought to be responsible for its pathogenesis, little is known about the molecular basis of...
- Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis
[作者:Ward, JE; Ren, RY; Toraldo, G; SooHoo, P; Guan, J; O'Hara, C; Jasuja, R; Trinkaus-Randall, V; Liao, RL; Connors, LH; Seldin, DC,期刊:Blood, 页码:6610-6617 , 文章类型: Article,,卷期:2011年118-25]
- Systemic AL amyloidosis results from the aggregation of an amyloidogenic immunoglobulin (Ig) light chain (LC) usually produced by a plasma cell clone in the bone marrow. AL is the most rapidly fatal of the systemic amylo...
- General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL
[作者:Fazi, C; Scarfo, L; Pecciarini, L; Cottini, F; Dagklis, A; Janus, A; Talarico, A; Scielzo, C; Sala, C; Toniolo, D; Caligaris-Cappio, F; Ghia, P,期刊:Blood, 页码:6618-6625 , 文章类型: Article,,卷期:2011年118-25]
- Monoclonal B-cell lymphocytosis (MBL) is classified as chronic lymphocytic leukemia (CLL)-like, atypical CLL, and CD5(-) MBL. The number of B cells per microliter divides CLL-like MBL into MBL associated with lymphocytos...
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