- Retinoblastoma Protein Modulates the Inverse Relationship between Cellular Proliferation and Elastogenesis
[作者:Sen, S; Bunda, S; Shi, JY; Wang, A; Mitts, TF; Hinek, A,期刊:Journal of Biological Chemistry, 页码:36580-36591 , 文章类型: Article,,卷期:2011年286-42]
- The mechanism that leads to the inverse relationship between heightened cellular proliferation and the cessation of elastic fibers production, observed during formation of the arterial occlusions and dermal scars, is not...
- ABIN1 Protein Cooperates with TAX1BP1 and A20 Proteins to Inhibit Antiviral Signaling
[作者:Gao, LL; Coope, H; Grant, S; Ma, A; Ley, SC; Harhaj, EW,期刊:Journal of Biological Chemistry, 页码:36592-36602 , 文章类型: Article,,卷期:2011年286-42]
- Upon virus infection, the innate immune response provides the first line of protection and rapidly induces type I interferons (IFN alpha/beta), which mediate potent antiviral effects. To maintain homeostasis and prevent ...
- Delineation of the Role of Toll-like Receptor Signaling during Peritonitis by a Gradually Growing Pathogenic Escherichia coli
[作者:van 't Veer, C; van den Pangaart, PS; Kruijswijk, D; Florquin, S; de Vos, AF; van der Poll, T,期刊:Journal of Biological Chemistry, 页码:36603-36618 , 文章类型: Article,,卷期:2011年286-42]
- In a mouse model of Escherichia coli sepsis characterized by a primary peritoneal infection with 10(4) E. coli and a gradually growing bacterial load, we here show that the early cytokine response and antibacterial defen...
- Self-catalyzed Site-specific Depurination of G Residues Mediated by Cruciform Extrusion in Closed Circular DNA Plasmids
[作者:Amosova, O; Kumar, V; Deutsch, A; Fresco, JR,期刊:Journal of Biological Chemistry, 页码:36322-36330 , 文章类型: Article,,卷期:2011年286-42]
- A major variety of "spontaneous" genomic damage is endogenous generation of apurinic sites. Depurination rates vary widely across genomes, occurring with higher frequency at "depurination hot spots." Recently, we discove...
- Inhibition of c-Jun-N-terminal Kinase Increases Cardiac Peroxisome Proliferator-activated Receptor alpha Expression and Fatty Acid Oxidation and Prevents Lipopolysaccharide-induced Heart Dysfunction
[作者:Drosatos, K; Drosatos-Tampakaki, Z; Khan, R; Homma, S; Schulze, PC; Zannis, VI; Goldberg, IJ,期刊:Journal of Biological Chemistry, 页码:36331-36339 , 文章类型: Article,,卷期:2011年286-42]
- Septic shock results from bacterial infection and is associated with multi-organ failure, high mortality, and cardiac dysfunction. Sepsis causes both myocardial inflammation and energy depletion. We hypothesized that red...
- Adaptor Protein-3 (AP-3) Complex Mediates the Biogenesis of Acidocalcisomes and Is Essential for Growth and Virulence of Trypanosoma brucei
[作者:Huang, GZ; Fang, JM; Sant'Anna, C; Li, ZH; Wellems, DL; Rohloff, P; Docampo, R,期刊:Journal of Biological Chemistry, 页码:36619-36630 , 文章类型: Article,,卷期:2011年286-42]
- Acidocalcisomes are acidic calcium and polyphosphate storage organelles found in a diverse range of organisms. Here we present evidence that the biogenesis of acidocalcisomes in Trypanosoma brucei is linked to the expres...
- Induction of Apoptotic Genes by a p73-Phosphatase and Tensin Homolog (p73-PTEN) Protein Complex in Response to Genotoxic Stress
[作者:Lehman, JA; Waning, DL; Batuello, CN; Cipriano, R; Kadakia, MP; Mayo, LD,期刊:Journal of Biological Chemistry, 页码:36631-36640 , 文章类型: Article,,卷期:2011年286-42]
- The p53 family member, p73, has been characterized as a tumor suppressor and functions in a similar manner as p53 to induce cellular death. The phosphatase and tensin homolog (PTEN) can function as a dual specificity lip...
- Structural Defects in the Regulatory Particle-Core Particle Interface of the Proteasome Induce a Novel Proteasome Stress Response
[作者:Park, S; Kim, W; Tian, G; Gygi, SP; Finley, D,期刊:Journal of Biological Chemistry, 页码:36652-36666 , 文章类型: Article,,卷期:2011年286-42]
- Proteasomes consist of a 19-subunit regulatory particle (RP) and 28-subunit core particle (CP), an alpha(7)alpha(7)alpha(7)alpha(7) structure. The RP recognizes substrates and translocates them into the CP for degradatio...
- Interaction of Nectin-like Molecule 2 with Integrin alpha(6)beta(4) and Inhibition of Disassembly of Integrin alpha(6)beta(4) from Hemidesmosomes
[作者:Mizutani, K; Kawano, S; Minami, A; Waseda, M; Ikeda, W; Takai, Y,期刊:Journal of Biological Chemistry, 页码:36667-36676 , 文章类型: Article,,卷期:2011年286-42]
- In normal epithelial cells, integrin alpha(6)beta(4) is abundantly expressed and forms hemidesmosomes, which is a cellular structure that mediates cell-extracellular matrix binding. In many types of cancer cells, integri...
- MicroRNA-99a Inhibits Hepatocellular Carcinoma Growth and Correlates with Prognosis of Patients with Hepatocellular Carcinoma
[作者:Li, D; Liu, XG; Lin, L; Hou, J; Li, N; Wang, CM; Wang, P; Zhang, Q; Zhang, P; Zhou, WP; Wang, ZX; Ding, GS; Zhuang, SM; Zheng, LM; Tao, WZ; Cao, XT,期刊:Journal of Biological Chemistry, 页码:36677-36685 , 文章类型: Article,,卷期:2011年286-42]
- In our in-depth analysis carried out by the Illumina Solexa massive parallel signature sequencing, microRNA-99a (miR-99a) was found to be the sixth abundant microRNA in the miR-Nome of normal human liver but was markedly...
- Forced Gating Motions by a Substituted Titratable Side Chain at the Bundle Crossing of a Potassium Channel
[作者:Khurana, A; Shao, ES; Kim, RY; Vilin, YY; Huang, XY; Yang, RY; Kurata, HT,期刊:Journal of Biological Chemistry, 页码:36686-36693 , 文章类型: Article,,卷期:2011年286-42]
- Voltage-gated sodium channels underlie the upstroke of action potentials and are fundamental to neuronal excitability. Small changes in the behavior of these channels are sufficient to change neuronal firing and trigger ...
- LIM Kinase Has a Dual Role in Regulating Lamellipodium Extension by Decelerating the Rate of Actin Retrograde Flow and the Rate of Actin Polymerization
[作者:Ohashi, K; Fujiwara, S; Watanabe, T; Kondo, H; Kiuchi, T; Sato, M; Mizuno, K,期刊:Journal of Biological Chemistry, 页码:36340-36351 , 文章类型: Article,,卷期:2011年286-42]
- Lamellipodium extension is crucial for cell migration and spreading. The rate of lamellipodium extension is determined by the balance between the rate of actin polymerization and the rate of actin retrograde flow. LIM ki...
- Phosphorylation of Right Open Reading Frame 2 (Rio2) Protein Kinase by Polo-like Kinase 1 Regulates Mitotic Progression
[作者:Liu, T; Deng, M; Li, JH; Tong, XM; Wei, Q; Ye, X,期刊:Journal of Biological Chemistry, 页码:36352-36360 , 文章类型: Article,,卷期:2011年286-42]
- Polo-like kinase 1 (Plk1) plays essential roles during multiple stages of mitosis by phosphorylating a number of substrates. Here, we report that the atypical protein kinase Rio2 is a novel substrate of Plk1 and can be p...
- Local Elongation of Endothelial Cell-anchored von Willebrand Factor Strings Precedes ADAMTS13 Protein-mediated Proteolysis
[作者:De Ceunynck, K; Rocha, S; Feys, HB; De Meyer, SF; Uji-i, H; Deckmyn, H; Hofkens, J; Vanhoorelbeke, K,期刊:Journal of Biological Chemistry, 页码:36361-36367 , 文章类型: Article,,卷期:2011年286-42]
- Platelet-decorated von Willebrand factor (VWF) strings anchored to the endothelial surface are rapidly cleaved by ADAMTS13. Individual VWF string characteristics such as number, location, and auxiliary features of the AD...
- Polynucleotide Kinase and Aprataxin-like Forkhead-associated Protein (PALF) Acts as Both a Single-stranded DNA Endonuclease and a Single-Stranded DNA 3 ' Exonuclease and Can Participate in DNA End Joining in a Biochemical System
[作者:Li, SC; Kanno, S; Watanabe, R; Ogiwara, H; Kohno, T; WatanabeO, G; Yasui, A; Lieber, MR,期刊:Journal of Biological Chemistry, 页码:36368-36377 , 文章类型: Article,,卷期:2011年286-42]
- Polynucleotide kinase and aprataxin-like forkhead-associated protein (PALF, also called aprataxin- and PNK-like factor (APLF)) has been shown to have nuclease activity and to use its forkhead-associated domain to bind to...
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