- Roles of Glucose in Photoreceptor Survival
[作者:Chertov, AO; Holzhausen, L; Kuok, IT; Couron, D; Parker, E; Linton, JD; Sadilek, M; Sweet, IR; Hurley, JB,期刊:Journal of Biological Chemistry, 页码:34700-34711 , 文章类型: Article,,卷期:2011年286-40]
- Vertebrate photoreceptor neurons have a high demand for metabolic energy, and their viability is very sensitive to genetic and environmental perturbations. We investigated the relationship between energy metabolism and c...
- Decorin Antagonizes IGF Receptor I (IGF-IR) Function by Interfering with IGF-IR Activity and Attenuating Downstream Signaling
[作者:Iozzo, RV; Buraschi, S; Genua, M; Xu, SQ; Solomides, CC; Peiper, SC; Gomella, LG; Owens, RC; Morrione, A,期刊:Journal of Biological Chemistry, 页码:34712-34721 , 文章类型: Article,,卷期:2011年286-40]
- We have recently discovered that the insulin-like growth factor receptor I (IGF-IR) is up-regulated in human invasive bladder cancer and promotes migration and invasion of transformed urothelial cells. The proteoglycan d...
- Long Term Potentiation Is Impaired in Membrane Glycoprotein CD200-deficient Mice A ROLE FOR Toll-LIKE RECEPTOR ACTIVATION
[作者:Costello, DA; Lyons, A; Denieffe, S; Browne, TC; Cox, FF; Lynch, MA,期刊:Journal of Biological Chemistry, 页码:34722-34732 , 文章类型: Article,,卷期:2011年286-40]
- The membrane glycoprotein CD200 is expressed on several cell types, including neurons, whereas expression of its receptor, CD200R, is restricted principally to cells of the myeloid lineage, including microglia. The inter...
- Histone Methyltransferase SETD3 Regulates Muscle Differentiation
[作者:Eom, GH; Kim, KB; Kim, JH; Kim, JY; Kim, JR; Kee, HJ; Kim, DW; Choe, N; Park, HJ; Son, HJ; Choi, SY; Kook, H; Seo, SB,期刊:Journal of Biological Chemistry, 页码:34733-34742 , 文章类型: Article,,卷期:2011年286-40]
- Histone lysine methylation, as one of the most important factors in transcriptional regulation, is associated with a various physiological conditions. Using a bioinformatics search, we identified and subsequently cloned ...
- Interferon-induced Antiviral Protein MxA Interacts with the Cellular RNA Helicases UAP56 and URH49
[作者:Wisskirchen, C; Ludersdorfer, TH; Muller, DA; Moritz, E; Pavlovic, J,期刊:Journal of Biological Chemistry, 页码:34743-34751 , 文章类型: Article,,卷期:2011年286-40]
- Mx proteins are a family of large GTPases that are induced exclusively by interferon-alpha/beta and have a broad antiviral activity against several viruses, including influenza A virus (IAV). Although the antiviral activ...
- Orientation and Cellular Distribution of Membrane-bound Catechol-O-methyltransferase in Cortical Neurons IMPLICATIONS FOR DRUG DEVELOPMENT
[作者:Chen, JS; Song, J; Yuan, PX; Tian, QJ; Ji, YY; Ren-Patterson, R; Liu, GP; Sei, Y; Weinberger, DR,期刊:Journal of Biological Chemistry, 页码:34752-34760 , 文章类型: Article,,卷期:2011年286-40]
- Catechol-O-methyltransferase (COMT) is a key enzyme for inactivation and metabolism of catechols, including dopamine, norepinephrine, caffeine, and estrogens. It plays an important role in cognition, arousal, pain sensit...
- Invasion of Cryptococcus neoformans into Human Brain Microvascular Endothelial Cells Is Mediated through the Lipid Rafts-Endocytic Pathway via the Dual Specificity Tyrosine Phosphorylation-regulated Kinase 3 (DYRK3)
[作者:Huang, SH; Long, M; Wu, CH; Kwon-Chung, KJ; Chang, YC; Chi, F; Lee, S; Jong, A,期刊:Journal of Biological Chemistry, 页码:34761-34769 , 文章类型: Article,,卷期:2011年286-40]
- Cryptococcus neoformans is a neurotropic fungal pathogen, which provokes the onset of devastating meningoencephalitis. Weused human brain microvascular endothelial cells (HBMEC) as the in vitro model to investigate how C...
- Termination of Protein Synthesis in Mammalian Mitochondria
[作者:Chrzanowska-Lightowlers, ZMA; Pajak, A; Lightowlers, RN,期刊:Journal of Biological Chemistry, 页码:34479-34485 , 文章类型: Review,,卷期:2011年286-40]
- All mechanisms of protein synthesis can be considered in four stages: initiation, elongation, termination, and ribosome recycling. Remarkable progress has been made in understanding how these processes are mediated in th...
- Elevated Calcium Acutely Regulates Dynamic Interactions of NHERF2 and NHE3 Proteins in Opossum Kidney (OK) Cell Microvilli
[作者:Zhu, XJ; Cha, BY; Zachos, NC; Sarker, R; Chakraborty, M; Chen, TE; Kovbasnjuk, O; Donowitz, M,期刊:Journal of Biological Chemistry, 页码:34486-34496 , 文章类型: Article,,卷期:2011年286-40]
- The brush border (BB) Na(+)H(+) exchanger NHE3 is rapidly activated or inhibited by changes in trafficking, which mimics renal and intestinal physiology. However, there is a paradox in that NHE3 has limited mobility in t...
- Glycosaminoglycans and Glucose Prevent Apoptosis in 4-Methylumbelliferone-treated Human Aortic Smooth Muscle Cells
[作者:Vigetti, D; Rizzi, M; Moretto, P; Deleonibus, S; Dreyfuss, JM; Karousou, E; Viola, M; Clerici, M; Hascall, VC; Ramoni, MF; De Luca, G; Passi, A,期刊:Journal of Biological Chemistry, 页码:34497-34503 , 文章类型: Article,,卷期:2011年286-40]
- Smooth muscle cells (SMCs) have a pivotal role in cardiovascular diseases and are responsible for hyaluronan (HA) deposition in thickening vessel walls. HA regulates SMC proliferation, migration, and inflammation, which ...
- Biochemical Impact of the Host Adaptation-associated PB2 E627K Mutation on the Temperature-dependent RNA Synthesis Kinetics of Influenza A Virus Polymerase Complex
[作者:Aggarwal, S; Dewhurst, S; Takimoto, T; Kim, B,期刊:Journal of Biological Chemistry, 页码:34504-34513 , 文章类型: Article,,卷期:2011年286-40]
- Most avian influenza A viruses, which preferentially replicate at the high temperatures found in the digestive tract of birds, have a glutamic acid at residue 627 of the viral RNA polymerase PB2 subunit (Glu-627), wherea...
- Change in Conformation with Reduction of alpha-Helix Content Causes Loss of Neutrophil Binding Activity in Fully Cytotoxic Shiga Toxin 1
[作者:Brigotti, M; Carnicelli, D; Arfilli, V; Rocchi, L; Ricci, F; Pagliaro, P; Tazzari, PL; Vara, AG; Amelia, M; Manoli, F; Monti, S,期刊:Journal of Biological Chemistry, 页码:34514-34521 , 文章类型: Article,,卷期:2011年286-40]
- Shiga toxins (Stx) play an important role in the pathogenesis of hemolytic uremic syndrome, a life-threatening renal sequela of human intestinal infection caused by specific Escherichia coli strains. Stx target a restric...
- Early Murine T-lymphocyte Activation Is Accompanied by a Switch from N-Glycolyl- to N-Acetyl-neuraminic Acid and Generation of Ligands for Siglec-E
[作者:Redelinghuys, P; Antonopoulos, A; Liu, Y; Campanero-Rhodes, MA; McKenzie, E; Haslam, SM; Dell, A; Feizi, T; Crocker, PR,期刊:Journal of Biological Chemistry, 页码:34522-34532 , 文章类型: Article,,卷期:2011年286-40]
- It is well established that murine T-lymphocyte activation is accompanied by major changes in cell-surface sialylation, potentially influencing interactions with sialic acid-binding immunoglobulin-like lectins (siglecs)....
- Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes
[作者:Ge, X; Chen, C; Hui, XY; Wang, Y; Lam, KSL; Xu, AM,期刊:Journal of Biological Chemistry, 页码:34533-34541 , 文章类型: Article,,卷期:2011年286-40]
- Fibroblast growth factor 21 (FGF21) is a liver-secreted endocrine factor with multiple beneficial effects on obesity-related disorders. It enhances glucose uptake by inducing the expression of glucose transporter-1 (GLUT...
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