- Memantine for the treatment of Alzheimer's disease
[作者:Farlow, MR; Graham, SM; Alva, G,期刊:Drug safety, 页码:577-585 , 文章类型: Article,,卷期:2008年31-7]
- Background: Memantine, a moderate-affinity, uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, is the first non-cholinergic agent approved for the treatment of Alzheimer's disease (AD), and the first medi...
- Influence of regulatory measures on the rate of spontaneous adverse drug reaction reporting in Italy
[作者:Motola, D; Vargiu, A; Leone, R; Conforti, A; Moretti, U; Vaccheri, A; Velo, G; Montanaro, N,期刊:Drug safety, 页码:609-616 , 文章类型: Article,,卷期:2008年31-7]
- Background: The reporting of adverse drug reactions (ADRs) is the mainstay of post-marketing surveillance systems. Under-reporting and selective reporting are considered the main limitations of a spontaneous reporting-ba...
- Safety of low-dose aprotinin in coronary artery bypass graft surgery
[作者:Kluth, M; Lueth, JU; Zittermann, A; Lanzenstiel, M; Koerfer, R; Inoue, K,期刊:Drug safety, 页码:617-626 , 文章类型: Article,,卷期:2008年31-7]
- Background: The antifibrinolytic agent aprotinin is used to limit blood loss in cardiac surgery. In a recently performed multicentre observational study, the use of aprotinin was dose-dependently associated with a higher...
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