- A benefit-risk assessment of benzbromarone in the treatment of gout - Was its withdrawal from the market in the best interest of patients?
[作者:Lee, MHH; Graham, GG; Williams, KM; Day, RO,期刊:Drug safety, 页码:643-665 , 文章类型: Review,,卷期:2008年31-8]
- Benzbromarone, a potent uricosuric drug, was introduced in the 1970s and was viewed as having few associated serious adverse reactions. It was registered in about 20 countries throughout Asia, South America and Europe. I...
- Influence of chemical structure on hypersensitivity reactions induced by antiepileptic drugs - The role of the aromatic ring
[作者:Handoko, KB; van Puijenbroek, EP; Bijl, AH; Hermens, WAJJ; Rijkom, JEFZV; Hekster, YA; Egberts, TCG,期刊:Drug safety, 页码:695-702 , 文章类型: Article,,卷期:2008年31-8]
- Objective: Antiepileptic drugs (AEDs) can cause various 'idiosyncratic' hypersensitivity reactions, i.e. the mechanism by which AEDs induce hypersensitivity is unknown. The aim of this study was to assess whether the pre...
- Drug-related deaths - An analysis of the Italian spontaneous reporting database
[作者:Leone, R; Sottosanti, L; Iorio, ML; Santuccio, C; Conforti, A; Sabatini, V; Moretti, U; Venegoni, M,期刊:Drug safety, 页码:703-713 , 文章类型: Article,,卷期:2008年31-8]
- Background: Adverse drug reactions (ADRs) represent a major public health concern, with death as the ultimate adverse drug outcome. Despite the relevance of this, the frequency of fatal ADRs (FADRs) is to a large extent ...
- Associations between venous thromboembolism and antipsychotics - A study of the WHO database of adverse drug reactions
[作者:Hagg, S; Bate, A; Stahl, M; Spigset, O,期刊:Drug safety, 页码:685-694 , 文章类型: Article,,卷期:2008年31-8]
- Background: Concern has been raised about the occurrence of venous thromboembolism (VTE) during treatment with antipsychotics. However, to date, clozapine is the only antipsychotic agent for which recurring evidence supp...
- Safety of efalizumab therapy in patients with moderate to severe psoriasis - An open-label extension of a phase IIIb trial
[作者:Hamilton, T; Menter, A; Caro, I; Compton, P; Sobell, J; Papp, KA,期刊:Drug safety, 页码:715-726 , 文章类型: Article,,卷期:2008年31-8]
- Background: Psoriasis is a chronic autoimmune disease characterized by infiltration of the dermis and epidermis by activated T cells and the hyperproliferation and abnormal differentiation of keratinocytes. It is a life-...
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