- Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice
[作者:Camerer, E; Regard, JB; Cornelissen, I; Srinivasan, Y; Duong, DN; Palmer, D; Pham, TH; Wong, JS; Pappu, R; Coughlin, SR,期刊:Journal of clinical investigation, 页码:1871-1879 , 文章类型: Article,,卷期:2009年119-7]
- Maintenance of vascular integrity is critical for homeostasis, and temporally and spatially regulated vascular leak is a central feature of inflammation. Sphingosine-l-phosphate (S1P) can regulate endothelial barrier fun...
- The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents
[作者:Celton-Morizur, S; Merlen, G; Couton, D; Margall-Ducos, G; Desdouets, C,期刊:Journal of clinical investigation, 页码:1880-1887 , 文章类型: Article,,卷期:2009年119-7]
- The formation of polyploid cells is part of the developmental program of several tissues. During postnatal development, binucleated tetraploid cells arise in the liver, caused by failure in cytokinesis. In this report, w...
- The diabetes gene Pdx1 regulates the transcriptional network of pancreatic. endocrine progenitor cells in mice
[作者:Oliver-Krasinski, JM; Kasner, MT; Yang, JX; Crutchlow, MF; Rustgi, AK; Kaestner, KH; Stoffers, DA,期刊:Journal of clinical investigation, 页码:1888-1898 , 文章类型: Article,,卷期:2009年119-7]
- Heterozygous mutations in the gene encoding the pancreatic homeodomain transcription factor pancreatic duodenal homeobox 1 (PDX1) are associated with maturity onset diabetes of the young, type 4 (MODY4) and type 2 diabet...
- Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice
[作者:Shahangian, A; Chow, EK; Tian, XL; Kang, JR; Ghaffari, A; Liu, SY; Belperio, JA; Cheng, GH; Deng, JC,期刊:Journal of clinical investigation, 页码:1910-1920 , 文章类型: Article,,卷期:2009年119-7]
- Influenza-related complications continue to be a major cause of mortality worldwide. Due to unclear mechanisms, a substantial number of influenza-related deaths result from bacterial superinfections, particularly seconda...
- Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection
[作者:Andonegui, G; Zhou, H; Bullard, D; Kelly, MM; Mullaly, SC; McDonald, B; Long, EM; Robbins, SM; Kubes, P,期刊:Journal of clinical investigation, 页码:1921-1930 , 文章类型: Article,,卷期:2009年119-7]
- Recognition of LPS by TLR4 on immune sentinel cells such as macrophages is thought to be key to the recruitment of neutrophils to sites of infection with Gram-negative bacteria. To explore whether endothelial TLR4 plays ...
- Staphylococcus aureus activates type I IFN signaling in mice and humans through the Xr repeated sequences of protein A
[作者:Martin, FJ; Gomez, MI; Wetzel, DM; Memmi, G; O'Seaghdha, M; Soong, G; Schindler, C; Prince, A,期刊:Journal of clinical investigation, 页码:1931-1939 , 文章类型: Article,,卷期:2009年119-7]
- The activation of type I IFN signaling is a major component of host defense against viral infection, but it is not typically associated with immune responses to extracellular bacterial pathogens. Using mouse and human ai...
- Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice
[作者:Chelu, MG; Sarma, S; Sood, S; Wang, SF; van Oort, RJ; Skapura, DG; Li, N; Santonastasi, M; Muller, FU; Schmitz, W; Schotten, U; Anderson, ME; Valderrabano, M; Dobrev, D; Wehrens, XHT,期刊:Journal of clinical investigation, 页码:1940-1951 , 文章类型: Article,,卷期:2009年119-7]
- Atrial fibrillation (AF), the most common human cardiac arrhythmia, is associated with abnormal intraceHular Ca2+ handling. Diastolic Ca2+ release from the sarcoplasmic reticulum via "leaky" ryanodine receptors (RyR2s) i...
- In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene
[作者:Larochelle, A; Choi, U; Shou, Y; Naumann, N; Loktionova, NA; Clevenger, JR; Krouse, A; Metzger, M; Donahue, RE; Kang, E; Stewart, C; Persons, D; Malech, HL; Dunbar, CE; Sorrentino, BP,期刊:Journal of clinical investigation, 页码:1952-1963 , 文章类型: Article,,卷期:2009年119-7]
- Major limitations to gene therapy using HSCs are low gene transfer efficiency and the inability of most therapeutic genes to confer a selective advantage on the gene-corrected cells. One approach to enrich for gene-modif...
- A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase
[作者:Patel, N; Krishnan, S; Offman, MN; Krol, M; Moss, CX; Leighton, C; van Delft, FW; Holland, M; Liu, JZ; Alexander, S; Dempsey, C; Ariffin, H; Essink, M; Eden, TOB; Watts, C; Bates, PA; Saha, V,期刊:Journal of clinical investigation, 页码:1964-1973 , 文章类型: Article,,卷期:2009年119-7]
- L-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There is wide individual variation in pharmacokinetics, and little is known about its metabolism. The mechanisms of...
- Molecular disruption of RAD50 sensitizes human tumor cells to cisplatin-based chemotherapy
[作者:Abuzeid, WM; Jiang, XL; Shi, GL; Wang, H; Paulson, D; Araki, K; Jungreis, D; Carney, J; O'Malley, BW; Li, DQ,期刊:Journal of clinical investigation, 页码:1974-1985 , 文章类型: Article,,卷期:2009年119-7]
- Platinum-based drugs that induce DNA damage are commonly used first-line chemotherapy agents for testicular, bladder, head and neck, lung, esophageal, stomach, and ovarian cancers. The inherent resistance of tumors to DN...
- Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development
[作者:High, FA; Jain, R; Stoller, JZ; Antonucci, NB; Lu, MM; Loomes, KM; Kaestner, KH; Pear, WS; Epstein, JA,期刊:Journal of clinical investigation, 页码:1986-1996 , 文章类型: Article,,卷期:2009年119-7]
- Notch signaling is vital for proper cardiovascular development and function in both humans and animal models. Indeed, mutations in either JAGGED or NOTCH cause congenital heart disease in humans and NOTCH mutations are a...
- Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-beta(2) signaling
[作者:Iwao, K; Inatani, M; Matsumoto, Y; Ogata-Iwao, M; Takihara, Y; Irie, F; Yamaguchi, Y; Okinami, S; Tanihara, H,期刊:Journal of clinical investigation, 页码:1997-2008 , 文章类型: Article,,卷期:2009年119-7]
- During human embryogenesis, neural crest cells migrate to the anterior chamber of the eye and then differentiate into the inner layers of the cornea, the iridocorneal angle, and the anterior portion of the iris. When pro...
- Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration
[作者:Zhao, YY; Zhao, YD; Mirza, MK; Huang, JH; Potula, HHSK; Vogel, SM; Brovkovych, V; Yuan, JXJ; Wharton, J; Malik, AB,期刊:Journal of clinical investigation, 页码:2009-2018 , 文章类型: Article,,卷期:2009年119-7]
- Pulmonary hypertension (PH) is an unremitting disease defined by a progressive increase in pulmonary vascular resistance leading to right-sided heart failure. Using mice with genetic deletions of caveolin 1 (Cav1) and eN...
- The natriuretic peptide/guanylyl cyclase-A system functions as a stress-responsive regulator of angiogenesis in mice
[作者:Kuhn, M; Volker, K; Schwarz, K; Carbajo-Lozoya, J; Flogel, U; Jacoby, C; Stypmann, J; van Eickels, M; Gambaryan, S; Hartmann, M; Werner, M; Wieland, T; Schrader, J; Baba, HA,期刊:Journal of clinical investigation, 页码:2019-2030 , 文章类型: Article,,卷期:2009年119-7]
- Cardiac atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) modulate blood pressure and volume by activation of the receptor guanylyl cyclase-A (GC-A) and subsequent intracellular cGMP formation. Here w...
- An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans
[作者:Hou, YF; DeVoss, J; Dao, V; Kwek, S; Simko, JP; McNeel, DG; Anderson, MS; Fong, L,期刊:Journal of clinical investigation, 页码:2031-2041 , 文章类型: Article,,卷期:2009年119-7]
- Chronic prostatitis is a common disease of unclear etiology and has no specific treatment. Mice deficient in the expression of the autoimmune regulator (Aire) gene, which are defective in thymic expression of self antige...
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