- WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis
[作者:Konigshoff, M; Kramer, M; Balsara, N; Wilhelm, J; Amarie, OV; Jahn, A; Rose, F; Fink, L; Seeger, W; Schaefer, L; Gunther, A; Eickelberg, O,期刊:Journal of clinical investigation, 页码:772-787 , 文章类型: Article,,卷期:2009年119-4]
- Idiopathic pulmonary fibrosis (IPF) is characterized by distorted lung architecture and loss of respiratory function. Enhanced (myo)fibroblast activation, ECM deposition, and alveolar epithelial type II (ATII) cell dysfu...
- C3b deposition on human erythrocytes induces the formation of a membrane skeleton-linked protein complex
[作者:Karnchanaphanurach, P; Mirchev, R; Ghiran, I; Asara, JM; Papahadjopoulos-Sternberg, B; Nicholson-Weller, A; Golan, DE,期刊:Journal of clinical investigation, 页码:788-801 , 文章类型: Article,,卷期:2009年119-4]
- Decay-accelerating factor (DAF, also known as CD55), a glycosylphosphatidylinositol-linked (GPI-linked) plasma membrane protein, protects autologous cells from complement-mediated damage by inhibiting complement componen...
- PICK1 deficiency causes male infertility in mice by disrupting acrosome formation
[作者:Xiao, N; Kam, C; Shen, C; Jin, WY; Wang, JQ; Lee, KM; Jiang, LW; Xia, J,期刊:Journal of clinical investigation, 页码:802-812 , 文章类型: Article,,卷期:2009年119-4]
- Protein interacting with C kinase 1 (PICK1) is a peripheral membrane protein involved in protein trafficking, a function that has been well characterized in neurons. Here, we report that male mice deficient in PICK1 are ...
- Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice
[作者:Kim, H; Choi, HK; Shin, JH; Kim, KH; Huh, JY; Lee, SA; Ko, CY; Kim, HS; Shin, HI; Lee, HJ; Jeong, D; Kim, N; Choi, Y; Lee, SY,期刊:Journal of clinical investigation, 页码:813-825 , 文章类型: Article,,卷期:2009年119-4]
- Regulation of the formation and function of bone-resorbing osteoclasts (OCs) is a key to understanding the pathogenesis of skeletal disorders. Gene-targeting studies have shown that the RANK signaling pathway plays a cri...
- The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells
[作者:Ford, AM; Palmi, C; Bueno, C; Hong, D; Cardus, P; Knight, D; Cazzaniga, G; Enver, T; Greaves, M,期刊:Journal of clinical investigation, 页码:826-836 , 文章类型: Article,,卷期:2009年119-4]
- Chromosome translocation to generate the TEL-AML1 (also known as ETV6-RUNX1) chimeric fusion gene is a frequent and early or initiating event in childhood acute lymphoblastic leukemia (ALL). Our starting hypothesis was t...
- Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice
[作者:Kansara, M; Tsang, M; Kodjabachian, L; Sims, NA; Trivett, MK; Ehrich, M; Dobrovic, A; Slavin, J; Choong, PFM; Simmons, PJ; Dawid, IB; Thomas, DM,期刊:Journal of clinical investigation, 页码:837-851 , 文章类型: Article,,卷期:2009年119-4]
- Wnt signaling increases bone mass by stimulating osteoblast lineage commitment and expansion and forms the basis for novel anabolic therapeutic strategies being developed for osteoporosis. These strategies include derepr...
- Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice
[作者:Koegel, H; von Tobel, L; Schafer, M; Alberti, S; Kremmer, E; Mauch, C; Hohl, D; Wang, XJ; Beer, HD; Bloch, W; Nordheim, A; Werner, S,期刊:Journal of clinical investigation, 页码:899-910 , 文章类型: Article,,卷期:2009年119-4]
- The transcription factor serum response factor (SRF) plays a crucial role in the development of several organs. However, its role in the skin has not been explored. Here, we show that keratinocytes in normal human and mo...
- The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model
[作者:Mercher, T; Raffel, GD; Moore, SA; Cornejo, MG; Baudry-Bluteau, D; Cagnard, N; Jesneck, JL; Pikman, Y; Cullen, D; Williams, IR; Akashi, K; Shigematsu, H; Bourquin, JP; Giovannini, M; Vainchenker, W; Levine, RL; Lee, BH; Bernard, OA; Gilliland, DG,期刊:Journal of clinical investigation, 页码:852-864 , 文章类型: Article,,卷期:2009年119-4]
- Acute megakaryoblastic leukemia (AMKL) is a font of acute myeloid leukemia (AML) associated with a poor prognosis. The genetics and pathophysiology of AMKL are not well understood. We generated a knockin mouse model of t...
- Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis
[作者:Galluzzo, M; Pennacchietti, S; Rosano, S; Comoglio, PM; Michieli, P,期刊:Journal of clinical investigation, 页码:865-875 , 文章类型: Article,,卷期:2009年119-4]
- As a tumor grows, it requires increased amounts of oxygen. However, the tumor blood vessels that form to meet this demand are functionally impaired, leading to regions of hypoxia within the tumor. Such hypoxia is one of ...
- Inhibition of 11 beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans
[作者:Zhang, MZ; Xu, J; Yao, B; Yin, H; Cai, Q; Shrubsole, MJ; Chen, X; Kon, V; Zheng, W; Pozzi, A; Harris, RC,期刊:Journal of clinical investigation, 页码:876-885 , 文章类型: Article,,卷期:2009年119-4]
- Colorectal cancer (CRC) is a leading cause of cancer death, yet primary prevention remains the best approach to reducing overall morbidity and mortality. Studies have shown that COX-2-derived PGE(2) promotes CRC progress...
- Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans
[作者:Liu, K; Li, QZ; Delgado-Vega, AM; Abelson, AK; Sanchez, E; Kelly, JA; Li, L; Liu, Y; Zhou, JC; Yan, M; Ye, Q; Liu, SX; Xie, C; Zhou, XJ; Chung, SA; Pons-Estel, B; Witte, T; de Ramon, E; Bae, SC; Barizzone, N; Sebastiani, GD; Merrill, JT; Gregersen, PK; Gilkeson, GG; Kimberly, RP; Vyse, TJ; Kim, I; D'Alfonso, S; Martin, J; Harley, JB; Criswell, LA; Wakeland, EK; Alarcon-Riquelme, ME; Mohan, C,期刊:Journal of clinical investigation, 页码:911-923 , 文章类型: Article,,卷期:2009年119-4]
Immune-mediated nephritis contributes to disease in systemic lupus erythematosus, Goodpasture syndrome (caused by antibodies specific for glomerular basement membrane [anti-GBM antibodies]), and spontaneous lupus neph...
- Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases
[作者:Uetani, N; Bertozzi, K; Chagnon, MJ; Hendriks, W; Tremblay, ML; Bouchard, M,期刊:Journal of clinical investigation, 页码:924-935 , 文章类型: Article,,卷期:2009年119-4]
- Congenital anomalies affecting the ureter-bladder junction are frequent in newborns and are often associated with other developmental defects. However, the molecular and morphological processes underlying these malformat...
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