- Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents
[作者：Kanazawa, H; Ieda, M; Kimura, K; Arai, T; Kawaguchi-Manabe, H; Matsuhashi, T; Endo, J; Sano, M; Kawakami, T; Kimura, T; Monkawa, T; Hayashi, M; Iwanami, A; Okano, H; Okada, Y; Ishibashi-Ueda, H; Ogawa, S; Fukuda, K,期刊：Journal of clinical investigation, 页码：408-421 , 文章类型： Article，,卷期：2010年120-2]
- Although several cytokines and neurotrophic factors induce sympathetic neurons to transdifferentiate into cholinergic neurons in vitro, the physiological and pathophysiological roles of this remain unknown. During conges...
- TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice
[作者：Wang, Y; Ait-Oufella, H; Herbin, O; Bonnin, P; Ramkhelawon, B; Taleb, S; Huang, J; Offenstadt, G; Combadiere, C; Renia, L; Johnson, JL; Tharaux, PL; Tedgui, A; Mallat, Z,期刊：Journal of clinical investigation, 页码：422-432 , 文章类型： Article，,卷期：2010年120-2]
- Complicated abdominal aortic aneurysm (AAA) is a major cause of mortality in elderly men. Ang II-dependent TGF-beta activity promotes aortic aneurysm progression in experimental Marfan syndrome. However, the role of TGF-...
- Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease
[作者：Joutel, A; Monet-Lepretre, M; Gosele, C; Baron-Menguy, C; Hammes, A; Schmidt, S; Lemaire-Carrette, B; Domenga, V; Schedl, A; Lacombe, P; Hubner, N,期刊：Journal of clinical investigation, 页码：433-445 , 文章类型： Article，,卷期：2010年120-2]
- Cerebral ischemic small vessel disease (SVD) is the leading cause of vascular dementia and a major contributor to stroke in humans. Dominant mutations in NOTCH3 cause cerebral autosomal dominant arteriopathy with subcort...
- Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice
[作者：Lyubimova, A; Garber, JJ; Upadhyay, G; Sharov, A; Anastasoaie, F; Yajnik, V; Cotsarelis, G; Dotto, GP; Botchkarev, V; Snapper, SB,期刊：Journal of clinical investigation, 页码：446-456 , 文章类型： Article，,卷期：2010年120-2]
- The Rho family GTPases Cdc42 and Rac1 are critical regulators of the actin cytoskeleton and are essential for skin and hair function. Wiskott-Aldrich syndrome family proteins act downstream of these GTPases, controlling ...
- Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
[作者：Chalmin, F; Ladoire, S; Mignot, G; Vincent, J; Bruchard, M; Remy-Martin, JP; Boireau, W; Rouleau, A; Simon, B; Lanneau, D; De Thonel, A; Multhoff, G; Hamman, A; Martin, F; Chauffert, B; Solary, E; Zitvogel, L; Garrido, C; Ryffel, B; Borg, C; Apetoh, L; Rebe, C; Ghiringhelli, F,期刊：Journal of clinical investigation, 页码：457-471 , 文章类型： Article，,卷期：2010年120-2]
- Myeloid-derived suppressor cells (MDSCs) have been identified in humans and mice as a population of immature myeloid cells with the ability to suppress T cell activation. They accumulate in tumor-bearing mice and humans ...
- Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress
[作者：Chintalgattu, V; Ai, D; Langley, RR; Zhang, JH; Bankson, JA; Shih, TL; Reddy, AK; Coombes, KR; Daher, IN; Pati, S; Patel, SS; Pocius, JS; Taffet, GE; Buja, LM; Entman, ML; Khakoo, AY,期刊：Journal of clinical investigation, 页码：472-484 , 文章类型： Article，,卷期：2010年120-2]
- PDGFR is an important target for novel anticancer therapeutics because it is overexpressed in a wide variety of malignancies. Recently, however, several anticancer drugs that inhibit PDGFR signaling have been associated ...
- Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice
[作者：Shao, SJ; Liu, R; Wang, Y; Song, YM; Zuo, LH; Xue, LY; Lu, N; Hou, N; Wang, MR; Yang, X; Zhan, QM,期刊：Journal of clinical investigation, 页码：498-507 , 文章类型： Article，,卷期：2010年120-2]
- Disruption of mitotic events contributes greatly to genomic instability and results in mutator phenotypes. Indeed, abnormalities of mitotic components are closely associated with malignant transformation and tumorigenesi...
- beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
[作者：Morris, JP; Cano, DA; Selkine, S; Wang, SC; Hebrok, M,期刊：Journal of clinical investigation, 页码：508-520 , 文章类型： Article，,卷期：2010年120-2]
- Cellular plasticity in adult organs is involved in both regeneration and carcinogenesis. WT mouse acinar cells rapidly regenerate following injury that mimics acute pancreatitis, a process characterized by transient reac...
- The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients
[作者：Lin, RK; Hsieh, YS; Lin, PP; Hsu, HS; Chen, CY; Tang, YA; Lee, CF; Wang, YC,期刊：Journal of clinical investigation, 页码：521-532 , 文章类型： Article，,卷期：2010年120-2]
- DNA methyltransferase 1 (DNMT1) catalyzes DNA methylation and is overexpressed in many human diseases, including cancer. The tobacco-specific carcinogen NNK also induces DNA methylation. However, the role of DNMT1-mediat...
- The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells
[作者：Fernando, RI; Litzinger, M; Trono, P; Hamilton, DH; Schlom, J; Palena, C,期刊：Journal of clinical investigation, 页码：533-544 , 文章类型： Article，,卷期：2010年120-2]
- Metastatic disease is responsible for the majority of human cancer deaths. Understanding the molecular mechanisms of metastasis is a major step in designing effective cancer therapeutics. Here we show that the T-box tran...
- Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice
[作者：Escande, C; Chini, CCS; Nin, V; Dykhouse, KM; Novak, CM; Levine, J; van Deursen, J; Gores, GJ; Chen, JJ; Lou, ZK; Chini, EN,期刊：Journal of clinical investigation, 页码：545-558 , 文章类型： Article，,卷期：2010年120-2]
- The enzyme sirtuin 1 (SIRT1) is a critical regulator of many cellular functions, including energy metabolism. However, the precise mechanisms that modulate SIRT1 activity remain unknown. As SIRT1 activity in vitro was re...
- Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion
[作者：Bamboat, ZM; Ocuin, LM; Balachandran, VP; Obaid, H; Plitas, G; DeMatteo, RP,期刊：Journal of clinical investigation, 页码：559-569 , 文章类型： Article，,卷期：2010年120-2]
- TLRs are recognized as promoters of tissue damage, even in the absence of pathogens. TLR binding to damage-associated molecular patterns (DAMPs) released by injured host cells unleashes an inflammatory cascade that ampli...
- TLR4 signaling in effector CD4(+) T cells regulates TCR activation and experimental colitis in mice
[作者：Gonzalez-Navajas, JM; Fine, S; Law, J; Datta, SK; Nguyen, KP; Yu, M; Corr, M; Katakura, K; Eckman, L; Lee, J; Raz, E,期刊：Journal of clinical investigation, 页码：570-581 , 文章类型： Article，,卷期：2010年120-2]
- TLRs sense various microbial products. Their function has been best characterized in DCs and macrophages, where they act as important mediators of innate immunity. TLR4 is also expressed on CD4(+) T cells, but its physio...
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