- An orthosteric inhibitor of the Ras-Sos interaction
[作者:PATGIRI ANUPAM; YADAV KAMLESH K; ARORA PARAMJIT S; BARSAGI DAFNA,期刊:NATURE CHEMICAL BIOLOGY, 页码:585-587 , 文章类型: Article,,卷期:2011年7-9]
- Mimics of alpha-helices on protein surfaces have emerged as powerful reagents for antagonizing protein-protein interactions, which are difficult to target with small molecules. Here we describe the design of a cell-perme...
- Natural products reveal cancer cell dependence on oxysterol-binding proteins
[作者:BURGETT ANTHONY W G; POULSEN THOMAS B; WANGKANONT KITTIKHUN; ANDERSON D RYAN; KIKUCHI CHIKAKO; SHIMADA KOUSEI; OKUBO SHUICHI; FORTNER KEVIN C; MIMAKI YOSHIHIRO; KURODA MINPEI; MURPHY JASON P; SCHWALB DAVID J; PETRELLA EUGENE C; CORNELLATARACIDO IVAN; SCHIRLE MARKUS; TALLARICO JOHN A; SHAIR MATTHEW D,期刊:NATURE CHEMICAL BIOLOGY, 页码:639-647 , 文章类型: Article,,卷期:2011年7-9]
- Cephalostatin 1, OSW-1, ritterazine B and schweinfurthin A are natural products that potently, and in some cases selectively, inhibit the growth of cultured human cancer cell lines. The cellular targets of these small mo...
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