- Crystal structure of Pyrococcus furiosus PF2050, a member of the DUF2666 protein family
[作者:Han, BG; Jeong, KC; Cho, JW; Jeong, BC; Song, HK; Lee, JY; Shin, DH; Lee, S; Lee, BI,期刊:FEBS Letters, 页码:1384-1388 , 文章类型: Article,,卷期:2012年586-9]
- Pyrococcus furiosus PF2050 is an uncharacterized putative protein that contains two DUF2666 domains. Functional and structural studies of PF2050 have not previously been performed. In this study, we determined the crysta...
- Peripheral benzodiazepine receptor regulates vascular endothelial activations via suppression of the voltage-dependent anion channel-1
[作者:Joo, HK; Lee, YR; Lim, SY; Lee, EJ; Choi, S; Cho, EJ; Park, MS; Ryoo, S; Park, JB; Jeon, BH,期刊:FEBS Letters, 页码:1349-1355 , 文章类型: Article,,卷期:2012年586-9]
- Peripheral benzodiazepine receptor (PBR) is a multifunctional protein mainly found on the outer mitochondrial membrane. PBR expression is increased by tumor necrosis factor-alpha (TNF-alpha) in endothelial cells. Adenovi...
- Depression of mitochondrial metabolism by downregulation of cytoplasmic deacetylase, HDAC6
[作者:Kamemura, K; Ogawa, M; Ohkubo, S; Ohtsuka, Y; Shitara, Y; Komiya, T; Maeda, S; Ito, A; Yoshida, M,期刊:FEBS Letters, 页码:1379-1383 , 文章类型: Article,,卷期:2012年586-9]
- Mitochondria perform multiple functions critical to the maintenance of cellular homeostasis. Here we report that the downregulation of histone deacetylase 6 (HDAC6) causes a reduction in the net activity of mitochondrial...
- PIWIL4 regulates cervical cancer cell line growth and is involved in down-regulating the expression of p14ARF and p53
[作者:Su, C; Ren, ZJ; Wang, F; Liu, M; Li, X; Tang, H,期刊:FEBS Letters, 页码:1356-1362 , 文章类型: Article,,卷期:2012年586-9]
- Recently, PIWIL4 has been identified as a functional protein involved in tumorigenesis. Cervical cancer is the second most prevalent form of cancer worldwide. The relationship between PIWIL4 and cervical cancer is still ...
- Expression of the class II tumor suppressor gene RIG1 is directly regulated by p53 tumor suppressor in cancer cell lines
[作者:Hsu, TH; Chu, CC; Jiang, SY; Hung, MW; Ni, WC; Lin, HE; Chang, TC,期刊:FEBS Letters, 页码:1287-1293 , 文章类型: Article,,卷期:2012年586-9]
- Recent studies indicated that the RIG1 (RARRES3/TIG3) plays an important role in cell proliferation, differentiation, and apoptosis. However, the regulatory mechanism of RIG1 gene expression has not been clearly elucidat...
- Expression, purification and assembly of soluble multimeric MHC class II-invariant chain complexes
[作者:Majera, D; Kristan, KC; Neefjes, J; Turk, D; Mihelic, M,期刊:FEBS Letters, 页码:1318-1324 , 文章类型: Article,,卷期:2012年586-9]
- Major histocompatibility class (MHC) II molecules are essential for running adaptive immune response. They are produced in the ER and targeted to late endosomes with the help of invariant chain (Ii) trimers. Ii trimeriza...
- Genetic and molecular characterization reveals a unique nucleobase cation symporter 1 in Arabidopsis
[作者:Mourad, GS; Tippmann-Crosby, J; Hunt, KA; Gicheru, Y; Bade, K; Mansfield, TA; Schultes, NP,期刊:FEBS Letters, 页码:1370-1378 , 文章类型: Article,,卷期:2012年586-9]
- Locus At5g03555 encodes a nucleobase cation symporter 1 (AtNCS1) in the Arabidopsis genome. Arabidopsis insertion mutants, AtNcs1-1 and AtNcs1-3, were used for in planta toxic nucleobase analog growth studies and radio-l...
- Relative intensities of recognition factors at two combining sites of Ralstonia solanacearum lectin (RSL) for accommodating LFuc alpha 1 ->, DMan alpha 1 -> and Gal beta 1 -> 3/4GlcNAc glycotopes
[作者:Wu, AM; Liu, JH; Herp, A; Sudakevitz, D; Gilboa-Garber, N,期刊:FEBS Letters, 页码:1294-1299 , 文章类型: Article,,卷期:2012年586-9]
- Owing to the weak reactivities of monomeric DMan alpha 1 -> and Gal beta 1 -> 3/4GlcNAc beta (I-beta/II beta) glycotopes with Ralstonia solanacearum lectin (RSL), their recognition roles were previously ignored. In this ...
- SUMOylation of the kainate receptor subunit GluK2 contributes to the activation of the MLK3-JNK3 pathway following kainate stimulation
[作者:Zhu, QJ; Xu, Y; Du, CP; Hou, XY,期刊:FEBS Letters, 页码:1259-1264 , 文章类型: Article,,卷期:2012年586-9]
- Protein SUMOylation has been implicated in the pathogenesis of ischemic stroke. However, the underlying mechanisms remain unclear. Here, we found that global brain ischemia evokes a sustained elevation of GluK2 SUMOylati...
- Involvement of microRNA-93, a new regulator of PTEN/Akt signaling pathway, in regulation of chemotherapeutic drug cisplatin chemosensitivity in ovarian cancer cells
[作者:Fu, X; Tian, J; Zhang, L; Chen, Y; Hao, Q,期刊:FEBS Letters, 页码:1279-1286 , 文章类型: Article,,卷期:2012年586-9]
- The mechanisms underlying ovarian cancer cell resistance to cisplatin (CDDP) are not fully understood. MicroRNAs (miRNAs) play important roles in tumorigenesis and drug resistance. In this paper, we utilized microRNA arr...
- Kinetics of proton release and uptake by channelrhodopsin-2
[作者:Nack, M; Radu, I; Schultz, BJ; Resler, T; Schlesinger, R; Bondar, AN; del Val, C; Abbruzzetti, S; Viappiani, C; Bamann, C; Bamberg, E; Heberle, J,期刊:FEBS Letters, 页码:1344-1348 , 文章类型: Article,,卷期:2012年586-9]
- Electrophysiological experiments showed that the light-activated cation channel channelrhodopsin-2 (ChR2) pumps protons in the absence of a membrane potential. We determined here the kinetics of transient pH change using...
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