- Telomerase inhibition strategies by siRNAs against either hTR or hTERT in oral squamous cell carcinoma
[作者:Li, Y; Li, M; Yao, G; Geng, N; Xie, Y; Feng, Y; Zhang, P; Kong, X; Xue, J; Cheng, S; Zhou, J; Xiao, L,期刊:Cancer gene therapy, 页码:318-325 , 文章类型: Article,,卷期:2011年18-5]
- Human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) are considered effective molecular targets for current anticancer therapy. In this study, we investigated the therapeutic effects of targeting...
- An Ad5[E1-, E2b-]-HER2/neu vector induces immune responses and inhibits HER2/neu expressing tumor progression in Ad5 immune mice
[作者:Gabitzsch, ES; Xu, Y; Balcaitis, S; Balint, JP; Jones, FR,期刊:Cancer gene therapy, 页码:326-335 , 文章类型: Article,,卷期:2011年18-5]
- Immunotherapy is a promising approach for the treatment of cancers. Modified adenovirus 5 (Ad5) vectors have been used as a platform to deliver genes encoding tumor associated antigens (TAA). A major obstacle to Ad5 vect...
- Treatment of patient tumor-derived colon cancer xenografts by a TRAIL gene-armed oncolytic adenovirus
[作者:Zhou, W; Zhu, H; Chen, W; Hu, X; Pang, X; Zhang, J; Huang, X; Fang, B; He, C,期刊:Cancer gene therapy, 页码:336-345 , 文章类型: Article,,卷期:2011年18-5]
- Oncolytic virus-armed gene therapy may offer new treatment options and improve the prognosis for patients with colon cancer. In this study, we sought to further confirm the antitumor activity of oncolytic virus-armed tum...
- Evaluation and optimization of the administration of a selectively replicating herpes simplex viral vector to the brain by convection-enhanced delivery
[作者:White, E; Bienemann, A; Megraw, L; Bunnun, C; Gill, S,期刊:Cancer gene therapy, 页码:358-369 , 文章类型: Article,,卷期:2011年18-5]
- The direct intraparenchymal administration of oncolytic viral vectors by convection-enhanced delivery (CED) represents a promising new treatment strategy for malignant gliomas. However, there is no evidence to suggest th...
- Dendritic cell-directed lentivector vaccine induces antigen-specific immune responses against murine melanoma
[作者:Yang, HG; Hu, BL; Xiao, L; Wang, P,期刊:Cancer gene therapy, 页码:370-380 , 文章类型: Article,,卷期:2011年18-5]
- Lentivectors are potential vaccine delivery vehicles because they can efficiently transduce a variety of non-dividing cells, including antigen-presenting cells, and do not cause expression of extra viral proteins. To imp...
|