- Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis
[作者:Birsoy, K; Berry, R; Wang, T; Ceyhan, O; Tavazoie, S; Friedman, JM; Rodeheffer, MS,期刊:Development, 页码:4709-4719 , 文章类型: Article,,卷期:2011年138-21]
- Obesity is characterized by an expansion of white adipose tissue mass that results from an increase in the size and the number of adipocytes. However, the mechanisms responsible for the formation of adipocytes during dev...
- Vascular endothelial and endocardial progenitors differentiate as cardiomyocytes in the absence of Etsrp/Etv2 function
[作者:Palencia-Desai, S; Kohli, V; Kang, J; Chi, NC; Black, BL; Sumanas, S,期刊:Development, 页码:4721-4732 , 文章类型: Article,,卷期:2011年138-21]
- Previous studies have suggested that embryonic vascular endothelial, endocardial and myocardial lineages originate from multipotential cardiovascular progenitors. However, their existence in vivo has been debated and mol...
- The transcription factor BELLRINGER modulates phyllotaxis by regulating the expression of a pectin methylesterase in Arabidopsis
[作者:Peaucelle, A; Louvet, R; Johansen, JN; Salsac, F; Morin, H; Fournet, F; Belcram, K; Gillet, F; Hofte, H; Laufs, P; Mouille, G; Pelloux, J,期刊:Development, 页码:4733-4741 , 文章类型: Article,,卷期:2011年138-21]
- Plant leaves and flowers are positioned along the stem in a regular pattern. This pattern, which is referred to as phyllotaxis, is generated through the precise emergence of lateral organs and is controlled by gradients ...
- Blood vessels restrain pancreas branching, differentiation and growth
[作者:Magenheim, J; Ilovich, O; Lazarus, A; Klochendler, A; Ziv, O; Werman, R; Hija, A; Cleaver, O; Mishani, E; Keshet, E; Dor, Y,期刊:Development, 页码:4743-4752 , 文章类型: Article,,卷期:2011年138-21]
- How organ size and form are controlled during development is a major question in biology. Blood vessels have been shown to be essential for early development of the liver and pancreas, and are fundamental to normal and p...
- Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement
[作者:Arima, S; Nishiyama, K; Ko, T; Arima, Y; Hakozaki, Y; Sugihara, K; Koseki, H; Uchijima, Y; Kurihara, Y; Kurihara, H,期刊:Development, 页码:4763-4776 , 文章类型: Article,,卷期:2011年138-21]
- Angiogenesis is a complex process, which is accomplished by reiteration of modules such as sprouting, elongation and bifurcation, that configures branching vascular networks. However, details of the individual and collec...
- The heart endocardium is derived from vascular endothelial progenitors
[作者:Milgrom-Hoffman, M; Harrelson, Z; Ferrara, N; Zelzer, E; Evans, SM; Tzahor, E,期刊:Development, 页码:4777-4787 , 文章类型: Article,,卷期:2011年138-21]
- The embryonic heart is composed of two cell layers: the myocardium, which contributes to cardiac muscle tissue, and the endocardium, which covers the inner lumen of the heart. Whereas significant progress has been made t...
- Targeted deletion of Hand2 in enteric neural precursor cells affects its functions in neurogenesis, neurotransmitter specification and gangliogenesis, causing functional aganglionosis
[作者:Lei, J; Howard, MJ,期刊:Development, 页码:4789-4800 , 文章类型: Article,,卷期:2011年138-21]
- Targeted deletion of the bHLH DNA-binding protein Hand2 in the neural crest, impacts development of the enteric nervous system (ENS), possibly by regulating the transition from neural precursor cell to neuron. We tested ...
- ER71 directs mesodermal fate decisions during embryogenesis
[作者:Rasmussen, TL; Kweon, J; Diekmann, MA; Belema-Bedada, F; Song, QF; Bowlin, K; Shi, XZ; Ferdous, A; Li, TB; Kyba, M; Metzger, JM; Koyano-Nakagawa, N; Garry, DJ,期刊:Development, 页码:4801-4812 , 文章类型: Article,,卷期:2011年138-21]
- Er71 mutant embryos are nonviable and lack hematopoietic and endothelial lineages. To further define the functional role for ER71 in cell lineage decisions, we generated genetically modified mouse models. We engineered a...
- Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine
[作者:Perdigoto, CN; Schweisguth, F; Bardin, AJ,期刊:Development, 页码:4585-4595 , 文章类型: Article,,卷期:2011年138-21]
- Tight regulation of self-renewal and differentiation of adult stem cells ensures that tissues are properly maintained. In the Drosophila intestine, both commitment, i.e. exit from self-renewal, and terminal differentiati...
- Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas
[作者:Dalgin, G; Ward, AB; Hao, LT; Beattie, CE; Nechiporuk, A; Prince, VE,期刊:Development, 页码:4597-4608 , 文章类型: Article,,卷期:2011年138-21]
- The vertebrate endocrine pancreas has the crucial function of maintaining blood sugar homeostasis. This role is dependent upon the development and maintenance of pancreatic islets comprising appropriate ratios of hormone...
- Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers
[作者:Fukada, S; Yamaguchi, M; Kokubo, H; Ogawa, R; Uezumi, A; Yoneda, T; Matev, MM; Motohashi, N; Ito, T; Zolkiewska, A; Johnson, RL; Saga, Y; Miyagoe-Suzuki, Y; Tsujikawa, K; Takeda, S; Yamamoto, H,期刊:Development, 页码:4609-4619 , 文章类型: Article,,卷期:2011年138-21]
- Satellite cells, which are skeletal muscle stem cells, divide to provide new myonuclei to growing muscle fibers during postnatal development, and then are maintained in an undifferentiated quiescent state in adult skelet...
- Joint morphology in the insect leg: evolutionary history inferred from Notch loss-of-function phenotypes in Drosophila
[作者:Tajiri, R; Misaki, K; Yonemura, S; Hayashi, S,期刊:Development, 页码:4621-4626 , 文章类型: Article,,卷期:2011年138-21]
- Joints permit efficient locomotion, especially among animals with a rigid skeleton. Joint morphologies vary in the body of individual animals, and the shapes of homologous joints often differ across species. The diverse ...
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