- Cross talk between Id1 and its interactive protein Dril1 mediate fibroblast responses to transforming growth factor-beta in pulmonary fibrosis
[作者:Lin, L; Zhou, ZH; Zheng, L; Alber, S; Watkins, S; Ray, P; Kaminski, N; Zhang, YZ; Morse, D,期刊:American Journal of Pathology, 页码:337-346 , 文章类型: Article,,卷期:2008年173-2]
- The presence of activated fibroblasts or myofibroblasts represents a hallmark of progressive lung fibrosis. Because the transcriptional response of fibroblasts to transforming growth factor-beta 1 (TGF-beta(1)) is a dete...
- An experimental model of acute humoral rejection of renal allografts associated with concomitant cellular rejection
[作者:Bickerstaff, A; Pelletier, R; Wang, JJ; Nadasdy, G; DiPaola, N; Orosz, C; Satoskar, A; Hadley, G; Naclasdy, T,期刊:American Journal of Pathology, 页码:347-357 , 文章类型: Article,,卷期:2008年173-2]
- Acute humoral rejection (AHR), which occurs in up to 8% of kidney transplant recipients, is a significant cause of renal allograft dysfunction and loss. More efficacious treatment modalities are needed to eliminate or cu...
- Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment
[作者:Cheng, XW; Murohara, T; Kuzuya, M; Izawa, H; Sasaki, T; Obata, K; Nagata, K; Nishizawa, T; Kobayashi, M; Yamada, T; Kim, W; Sato, K; Shi, GP; Okumura, K; Yokota, M,期刊:American Journal of Pathology, 页码:358-369 , 文章类型: Article,,卷期:2008年173-2]
- The elastolytic activity of cathepsins in the myocardium is implicated in hypertensive heart failure (HF). Given that reactive oxygen species are also implicated in protease activation associated with cardiac remodeling,...
- Down syndrome fibroblast model of Alzheimer-related endosome pathology - Accelerated endocytosis promotes late endocytic defects
[作者:Cataldo, AM; Mathews, PM; Boiteau, AB; Hassinger, LC; Peterhoff, CM; Jiang, Y; Mullaney, K; Neve, RL; Gruenberg, J; Nixon, RA,期刊:American Journal of Pathology, 页码:370-384 , 文章类型: Article,,卷期:2008年173-2]
- Endocytic dysfunction is an early pathological change in Alzheimer's disease (AD) and Down's syndrome (DS). Using primary fibroblasts from DS individuals, we explored the interactions among endocytic compartments that ar...
- Transforming growth factor-beta stimulates intestinal epithelial focal adhesion kinase synthesis via Smad- and p38-dependent mechanisms
[作者:Walsh, MF; Ampasala, DR; Hatfield, J; Heide, RV; Suer, S; Rishi, AK; Basson, MD,期刊:American Journal of Pathology, 页码:385-399 , 文章类型: Article,,卷期:2008年173-2]
- Focal adhesion kinase (FAK) regulates cell migration, proliferation, and apoptosis. FAK protein is reduced at the edge of migrating gut epithelial sheets in vitro, but it has not been characterized in restitutive gut muc...
- Substance p-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitis
[作者:Koon, HW; Zhao, DZ; Xu, H; Bowe, C; Moss, A; Moyer, MP; Pothoulakis, C,期刊:American Journal of Pathology, 页码:400-410 , 文章类型: Article,,卷期:2008年173-2]
- Substance P (SP) regulates important intestinal functions, such as mucosal permeability, motility, chloride secretion, and inflammation via the neurokinin-1 receptor (NK-1R). Previous reports showed that vascularization ...
- Distinct functions of autoreactive memory and effector CD4(+) T cells in experimental autoimmune encephalomyelitis
[作者:Elyaman, W; Kivisakk, P; Reddy, J; Chitnis, T; Raddassi, K; Imitola, J; Bradshaw, E; Kuchroo, VK; Yagita, H; Sayegh, MH; Khoury, SJ,期刊:American Journal of Pathology, 页码:411-422 , 文章类型: Article,,卷期:2008年173-2]
- The persistence of human autoimmune diseases is thought to be mediated predominantly by memory T cells. We investigated the phenotype and migration of memory versus effector T cells in vivo in experimental autoimmune enc...
- Therapeutic administration of KM+ lectin protects mice against Paracoccidioides brasiliensis infection via interleukin-12 production in a Toll-like receptor 2-dependent mechanism
[作者:Coltri, KC; Oliveira, LL; Pinzan, CF; Vendruscolo, PE; Martinez, R; Goldman, MH; Panunto-Castelo, A; Roque-Barreira, MC,期刊:American Journal of Pathology, 页码:423-432 , 文章类型: Article,,卷期:2008年173-2]
- KM+ is a mannose-binding lectin from Artocarpus integrifolia that induces interleukin (IL)-12 production by macrophages and protective T helper I immune response against Leishmania major infection. in this study, we perf...
- Cyclic adenosine 3 ',5 '-monophosphate response element-binding protein and CCAAT/enhancer-binding protein mediate prostaglandin E-2-induced steroidogenic acute regulatory protein expression in endometriotic stromal cells
[作者:Hsu, CC; Lu, CW; Huang, BM; Wu, MH; Tsai, SJ,期刊:American Journal of Pathology, 页码:433-441 , 文章类型: Article,,卷期:2008年173-2]
- Aberrant expression of the steroidogenic acute regulatory (StAR) protein in human endometriotic stromal cells plays an important role in the development of endometriosis. Prostaglandin E-2 (PGE(2)) is a potent inducer of...
- Selective loss of podoplanin protein expression accompanies proteinuria and precedes alterations in podocyte morphology in a spontaneous proteinuric rat model
[作者:Koop, K; Eikmans, M; Wehland, M; Baelde, H; Ijpelaar, D; Kreutz, R; Kawachi, H; Kerjaschki, D; de Heer, E; Bruijn, JA,期刊:American Journal of Pathology, 页码:315-326 , 文章类型: Article,,卷期:2008年173-2]
- To evaluate changes during the development of proteinuria, podocyte morphology and protein expression were evaluated in spontaneously proteinuric, Dahl salt-sensitive (Dahl SS) rats. Dahl SS rats on a low-salt diet were ...
- Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan
[作者:Cai, WJ; He, JC; Zhu, L; Chen, X; Zheng, F; Striker, GE; Vlassara, H,期刊:American Journal of Pathology, 页码:327-336 , 文章类型: Article,,卷期:2008年173-2]
- We previously showed that the content of advanced glycation end products (AGEs) in the diet correlates with serum AGE levels, oxidant stress (OS), organ dysfunction, and lifespan. We now show that the addition of a chemi...
- Hyperglycemia induces apoptosis of human pancreatic islet endothelial cells - Effects of pravastatin on the Akt survival pathway
[作者:Favaro, E; Miceli, I; Bussolati, B; Schimitt-Ney, M; Perin, PC; Camussi, G; Zanone, MM,期刊:American Journal of Pathology, 页码:442-450 , 文章类型: Article,,卷期:2008年173-2]
- Pancreatic islet microendothelium and beta cells exhibit an interdependent physical and functional relationship. in this study, we analyzed the effect of chronic hyperglycemia on human pancreatic islet microendothelial c...
- Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction
[作者:Yung, HW; Calabrese, S; Hynx, D; Hemmings, BA; Cetin, I; Charnock-Jones, DS; Burton, GJ,期刊:American Journal of Pathology, 页码:451-462 , 文章类型: Article,,卷期:2008年173-2]
- Unexplained intrauterine growth restriction of the fetus (IUGR) results from impaired placental development, frequently associated with maternal malperfusion. Some cases are complicated further by preeclampsia (PE+IUGR)....
- CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development
[作者:Macias, E; de Marval, PLM; De Siervi, A; Conti, CJ; Senderowicz, AM; Rodriguez-Puebla, ML,期刊:American Journal of Pathology, 页码:526-535 , 文章类型: Article,,卷期:2008年173-2]
- It has been widely assumed that elevated CDK2 kinase activity plays a contributory role in tumorigenesis. We have previously shown that mice overexpressing CDK4 under control of the keratin 5 promoter (K5CDK4 mice) devel...
- Differential roles of telomere attrition in type I and II endometrial carcinogenesis
[作者:Akbay, EA; Contreras, CM; Perera, SA; Sullivan, JP; Broaddus, RR; Schorge, JO; Ashfaq, R; Saboorian, H; Wong, KK; Castrillon, DH,期刊:American Journal of Pathology, 页码:536-544 , 文章类型: Article,,卷期:2008年173-2]
- Endometrial cancer has been generally categorized into two broad groups of tumors, type I (TI) and type II (TII), with distinct epidemiological/clinical features and genetic alterations. Because telomere attrition appear...
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