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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共47条记录   RhoB Loss Prevents Streptozotocin-Induced Diabetes and Ameliorates Diabetic Complications in Mice [作者：Bravo-Nuevo, A; Sugimoto, H; Iyer, S; Fallon, Z; Lucas, JM; Kazerounian, S; Prendergast, GC; Kalluri, R; Shapiro, NI; Benjamin, LE,期刊：American Journal of Pathology, 页码：245-252 , 文章类型： Article，,卷期：2011年178-1] RhoB is an early-response gene whose expression is elevated by multiple cellular stresses; this gene plays an important role in cancer, macrophage motility, and apoptosis. These factors are essential for the onset of typ... Chlamydia trachomatis Infection Increases Fallopian Tube PROKR2 via TLR2 and NF kappa B Activation Resulting in a Microenvironment Predisposed to Ectopic Pregnancy [作者：Shaw, JLV; Wills, GS; Lee, KF; Horner, PJ; McClure, MO; Abrahams, VM; Wheelhouse, N; Jabbour, HN; Critchley, HOD; Entrican, G; Horne, AW,期刊：American Journal of Pathology, 页码：253-260 , 文章类型： Article，,卷期：2011年178-1] Chlamydia trachomatis and smoking are major risk factors for tubal ectopic pregnancy (EP), but the underlying mechanisms of these associations are not completely understood. Fallopian tube (FT) from women with EP exhibit... Post-Natal of Knockdown Fukutin-Related Protein Expression in Muscle by Long-Term RNA Interference Induces Dystrophic Pathology [作者：Wang, CH; Chan, YM; Tang, RH; Xiao, B; Lu, PJ; Keramaris-Vrantsis, E; Zheng, H; Qiao, CP; Jiang, JG; Li, JA; Ma, HI; Lu, QL; Xiao, XA,期刊：American Journal of Pathology, 页码：261-272 , 文章类型： Article，,卷期：2011年178-1] Limb-girdle muscular dystrophy 21 (LGMD2I) is caused by mutations in the fukutin-related protein (FKRP) gene. Unlike its severe allelic forms, LGMD2I usually involves slower onset and milder course without defects in the... Long-Term Blocking of Calcium Channels in mdx Mice Results in Differential Effects on Heart and Skeletal Muscle [作者：Jorgensen, LH; Blain, A; Greally, E; Laval, SH; Blamire, AM; Davison, BJ; Brinkmeie, H; MacGowan, GA; Schroder, HD; Bushby, K; Straub, V; Lochmuller, H,期刊：American Journal of Pathology, 页码：273-283 , 文章类型： Article，,卷期：2011年178-1] The disease mechanisms underlying dystrophin-deficient muscular dystrophy are complex, involving not only muscle membrane fragility, but also dysregulated calcium homeostasis. Specifically, it has been proposed that calc... Progranulin Is a Chemoattractant for Microglia and Stimulates Their Endocytic Activity [作者：Pickford, F; Marcus, J; Camargo, LM; Xiao, QR; Graham, D; Mo, JR; Burkhardt, M; Kulkarni, V; Crispino, J; Hering, H; Hutton, M,期刊：American Journal of Pathology, 页码：284-295 , 文章类型： Article，,卷期：2011年178-1] Mutations resulting in progranulin haploinsufficiency cause disease in patients with a subset of frontotemporal lobar degeneration; however, the biological functions of progranulin in the brain remain unknown. To address... Enhanced Epidermal Growth Factor, Hepatocyte Growth Factor, and Vascular Endothelial Growth Factor Expression in Tuberous Sclerosis Complex [作者：Parker, WE; Orlova, KA; Heuer, GG; Baybis, M; Aronica, E; Frost, M; Wong, M; Crino, PB,期刊：American Journal of Pathology, 页码：296-305 , 文章类型： Article，,卷期：2011年178-1] Epidermal growth factor (EGF), hepatocyte growth factor (HGF), and vascular endothelial growth factor (VEGF) regulate angiogenesis and cell growth in the developing brain. EGF, HGF, and VEGF modulate the activity of the ... Regulation of AMPK by the Ubiquitin Proteasome System [作者：Zungu, M; Schisler, JC; Essop, MF; McCudden, C; Patterson, C; WilIis, MS,期刊：American Journal of Pathology, 页码：4-11 , 文章类型： Review，,卷期：2011年178-1] The 5'-AMP-activated protein kinase (AMPK) functions as a metabolic fuel gauge that is activated in response to environmental stressors to restore cellular energy balance. In the heart, AMPK coordinates the activation of... Neprilysin-2 Is an Important beta-Amyloid Degrading Enzyme [作者：Hafez, D; Huang, JY; Huynh, AM; Valtierra, S; Rockenstein, E; Bruno, AM; Lu, B; DesGroseillers, L; Masliah, E; Marr, RA,期刊：American Journal of Pathology, 页码：306-312 , 文章类型： Article，,卷期：2011年178-1] Proteases that degrade the amyloid-p peptide (A beta) are important in protecting against Alzheimer's disease (AD), and understanding these proteases is critical to understanding AD pathology. Endopeptidases sensitive to... Interaction of a Specific Population of Human Embryonic Stem Cell-Derived Progenitor Cells with CD11b+ Cells Ameliorates Sepsis-Induced Lung Inflammatory Injury [作者：Toya, SP; Li, F; Bonini, MG; Gomez, I; Mao, M; Bachmaier, KW; Malik, AB,期刊：American Journal of Pathology, 页码：313-324 , 文章类型： Article，,卷期：2011年178-1] Human embryonic stem cells differentiated under mesoderm-inducing conditions have important therapeutic properties in sepsis-induced lung injury in mice. Single cell suspensions obtained from day 7 human embryoid bodies ... Innovative Proteomics for the Discovery of Systemically Accessible Cancer Biomarkers Suitable for Imaging and Targeted Therapies [作者：Turtoi, A; De Pauw, E; Castronovo, V,期刊：American Journal of Pathology, 页码：12-18 , 文章类型： Review，,卷期：2011年178-1] The discovery of biomarkers that are readily accessible through the circulating blood and are selectively over-expressed in pathological tissues has become a major research objective, particularly in the field of oncolog... Wound Macrophages as Key Regulators of Repair Origin, Phenotype, and Function [作者：Brancato, SK; Albina, JE,期刊：American Journal of Pathology, 页码：19-25 , 文章类型： Review，,卷期：2011年178-1] Recent results call for the reexamination of the phenotype of wound macrophages and their role in tissue repair. These results include the characterization of distinct circulating monocyte populations with temporally res... Insulin-Like Growth Factor System and Sporadic Malignant Melanoma [作者：Capoluongo, E,期刊：American Journal of Pathology, 页码：26-31 , 文章类型： Review，,卷期：2011年178-1] Insulin and insulin-like growth factors (IGFs) are important regulators of energy metabolism and growth. Several findings have outlined an important role played by this family of molecules in both tumor maintenance and d... Syndecan-1 in Breast Cancer Stroma Fibroblasts Regulates Extracellular Matrix Fiber Organization and Carcinoma Cell Motility [作者：Yang, N; Mosher, R; Seo, S; Beebe, D; Friedl, A,期刊：American Journal of Pathology, 页码：325-335 , 文章类型： Article，,卷期：2011年178-1] Stromal fibroblasts of breast carcinomas frequently express the cell surface proteoglycan syndecan-1 (Sdc1). In human breast carcinoma samples, stromal Sdc1 expression correlates with an organized, parallel, extracellula... Targeting the PI3K/mTOR Pathway in Murine Endocrine Cell Lines In Vitro and in Vivo Effects on Tumor Cell Growth [作者：Couderc, C; Poncet, G; Villaume, K; Blanc, M; Gadot, N; Walter, T; Lepinasse, F; Hervieu, V; Cordier-Bussat, M; Scoazec, JY; Roche, C,期刊：American Journal of Pathology, 页码：336-344 , 文章类型： Article，,卷期：2011年178-1] The mammalian target of rapamycin (mTOR) inhibitors, such as rapalogues, are a promising new tool for the treatment of metastatic gastroenteropancreatic endocrine tumors. However, their mechanisms of action remain to be ... A Mouse Model of Chikungunya Virus-Induced Musculoskeletal Inflammatory Disease Evidence of Arthritis, Tenosynovitis, Myositis, and Persistence [作者：Morrison, TE; Oko, L; Montgomery, SA; Whitmore, AC; Lotstein, AR; Gunn, BM; Elmore, SA; Heise, MT,期刊：American Journal of Pathology, 页码：32-40 , 文章类型： Article，,卷期：2011年178-1] Chikungunya virus (CHIKV), an emerging mosquitoborne Alphavirus, causes debilitating rheumatic disease in humans that can last for weeks to months. Starting in 2004, a CHIKV outbreak in the Indian Ocean region affected m... Unexpected Reduction of Skin Tumorigenesis on Expression of Cyclin-Dependent Kinase 6 in Mouse Epidermis [作者：Wang, XA; Sistrunk, C; Rodriguez-Puebla, ML,期刊：American Journal of Pathology, 页码：345-354 , 文章类型： Article，,卷期：2011年178-1] Cyclin-dependent kinases (CDKs) 4 and 6 are important regulators of the G(1) phase of the cell cycle, share 71% amino acid identity, and are expressed ubiquitously. As a result, it was assumed that each of these kinases ...