- Combination Therapy Targeting Both Tumor-Initiating and Differentiated Cell Populations in Prostate Carcinoma
[作者：Dubrovska, A; Elliott, J; Salamone, RJ; Kim, S; Aimone, LJ; Walker, JR; Watson, J; Sauveur-Michel, M; Garcia-Echeverria, C; Cho, CY; Reddy, VA; Schultz, PG,期刊：Clinical Cancer Research, 页码：5692-5702 , 文章类型： Article，,卷期：2010年16-23]
- Purpose: The cancer stem cell hypothesis predicts that standard prostate cancer monotherapy eliminates bulk tumor cells but not a tumor-initiating cell population, eventually leading to relapse. Many studies have sought ...
- Highly Purified Eicosapentaenoic Acid as Free Fatty Acids Strongly Suppresses Polyps in Apc(Min/+) Mice
[作者：Fini, L; Piazzi, G; Ceccarelli, C; Daoud, Y; Belluzzi, A; Munarini, A; Graziani, G; Fogliano, V; Selgrad, M; Garcia, M; Gasbarrini, A; Genta, RM; Boland, CR; Ricciardiello, L,期刊：Clinical Cancer Research, 页码：5703-5711 , 文章类型： Article，,卷期：2010年16-23]
- Purpose: Although cyclooxygenase (COX)-2 inhibitors could represent the most effective chemopreventive tool against colorectal cancer (CRC), their use in clinical practice is hampered by cardiovascular side effects. Cons...
- Noninvasive Radiofrequency Field Destruction of Pancreatic Adenocarcinoma Xenografts Treated with Targeted Gold Nanoparticles
[作者：Glazer, ES; Zhu, CH; Massey, KL; Thompson, CS; Kaluarachchi, WD; Hamir, AN; Curley, SA,期刊：Clinical Cancer Research, 页码：5712-5721 , 文章类型： Article，,卷期：2010年16-23]
- Purpose: Pancreatic carcinoma is one of the deadliest cancers with few effective treatments. Gold nanoparticles (AuNP) are potentially therapeutic because of the safety demonstrated thus far and their physiochemical char...
- Intratumoral Mediated Immunosuppression is Prognostic in Genetically Engineered Murine Models of Glioma and Correlates to Immunotherapeutic Responses
[作者：Kong, LY; Wu, AS; Doucette, T; Wei, J; Priebe, W; Fuller, GN; Qiao, W; Sawaya, R; Rao, G; Heimberger, AB,期刊：Clinical Cancer Research, 页码：5722-5733 , 文章类型： Article，,卷期：2010年16-23]
- Purpose: Preclinical murine model systems used for the assessment of therapeutics have not been predictive of human clinical responses, primarily because their clonotypic nature does not recapitulate the heterogeneous bi...
- New Strategies in Peripheral T-Cell Lymphoma: Understanding Tumor Biology and Developing Novel Therapies
[作者：Dunleavy, K; Piekarz, RL; Zain, J; Janik, JE; Wilson, WH; O'Connor, OA; Bates, SE,期刊：Clinical Cancer Research, 页码：5608-5617 , 文章类型： Article，,卷期：2010年16-23]
- Peripheral T-cell lymphomas (PTCL) constitute a group of heterogeneous diseases that are uncommon, representing, in Western countries, only approximately 10% of all non-Hodgkin lymphomas. They are typically associated wi...
- Benign Mesenchymal Stromal Cells in Human Sarcomas
[作者：Morozov, A; Downey, RJ; Healey, J; Moreira, AL; Lou, E; Franceschino, A; Dogan, Y; Leung, R; Edgar, M; LaQuaglia, M; Maki, RG; Moore, MAS,期刊：Clinical Cancer Research, 页码：5630-5640 , 文章类型： Article，,卷期：2010年16-23]
- Purpose: Recent evidence suggests that at least some sarcomas arise through aberrant differentiation of mesenchymal stromal cells (MSCs), but MSCs have never been isolated directly from human sarcoma specimens. Experimen...
- Integrative Genomics Analyses Reveal Molecularly Distinct Subgroups of B-Cell Chronic Lymphocytic Leukemia Patients with 13q14 Deletion
[作者：Mosca, L; Fabris, S; Lionetti, M; Todoerti, K; Agnelli, L; Morabito, F; Cutrona, G; Andronache, A; Matis, S; Ferrari, F; Gentile, M; Spriano, M; Callea, V; Festini, G; Molica, S; Deliliers, GL; Bicciato, S; Ferrarini, M; Neri, A,期刊：Clinical Cancer Research, 页码：5641-5653 , 文章类型： Article，,卷期：2010年16-23]
- Purpose: Chromosome 13q14 deletion occurs in a substantial number of chronic lymphocytic leukemia (CLL) patients and it is believed to play a pathogenetic role. The exact mechanisms involved in this lesion have not yet b...
- Foxo3a Suppression of Urothelial Cancer Invasiveness through Twist1, Y- Box- Binding Protein 1, and E-Cadherin Regulation
[作者：Shiota, M; Song, Y; Yokomizo, A; Kiyoshima, K; Tada, Y; Uchino, H; Uchiumi, T; Inokuchi, J; Oda, Y; Kuroiwa, K; Tatsugami, K; Naito, S,期刊：Clinical Cancer Research, 页码：5654-5663 , 文章类型： Article，,卷期：2010年16-23]
- Purpose: Invasion and metastasis are key steps in the progression of urothelial cancer (UC) into a critical disease. Foxo3a is a member of the Foxo transcription factor family that modulates the expression of various gen...
- Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer
[作者：Lockman, PR; Mittapalli, RK; Taskar, KS; Rudraraju, V; Gril, B; Bohn, KA; Adkins, CE; Roberts, A; Thorsheim, HR; Gaasch, JA; Huang, SY; Palmieri, D; Steeg, PS; Smith, QR,期刊：Clinical Cancer Research, 页码：5664-5678 , 文章类型： Article，,卷期：2010年16-23]
- Purpose: Brain metastases of breast cancer appear to be increasing in incidence, confer significant morbidity, and threaten to compromise gains made in systemic chemotherapy. The blood-tumor barrier (BTB) is compromised ...
- Quercetin Induces Tumor-Selective Apoptosis through Downregulation of Mcl-1 and Activation of Bax
[作者：Cheng, SP; Gao, N; Zhang, Z; Chen, G; Budhraja, A; Ke, ZJ; Son, YO; Wang, X; Luo, J; Shi, XL,期刊：Clinical Cancer Research, 页码：5679-5691 , 文章类型： Article，,卷期：2010年16-23]
- Purpose: To investigate the in vivo antitumor efficacy of quercetin in U937 xenografts and the functional roles of Mcl-1 and Bax in quercetin-induced apoptosis in human leukemia. Experimental Design: Leukemia cells were ...
- TRAIL-Induced Apoptosis Is Preferentially Mediated via TRAIL Receptor 1 in Pancreatic Carcinoma Cells and Profoundly Enhanced by XIAP Inhibitors
[作者：Stadel, D; Mohr, A; Ref, C; MacFarlane, M; Zhou, S; Humphreys, R; Bachem, M; Cohen, G; Moller, P; Zwacka, RM; Debatin, KM; Fulda, S,期刊：Clinical Cancer Research, 页码：5734-5749 , 文章类型： Article，,卷期：2010年16-23]
- Purpose: We previously reported that small molecule X-linked inhibitor of apoptosis (XIAP) inhibitors synergize with soluble TRAIL to trigger apoptosis in pancreatic carcinoma cells. Because cancers may preferentially si...
- Monoclonal Antibodies to Fibroblast Growth Factor Receptor 2 Effectively Inhibit Growth of Gastric Tumor Xenografts
[作者：Zhao, WM; Wang, LH; Park, H; Chhim, S; Tanphanich, M; Yashiro, M; Kim, KJ,期刊：Clinical Cancer Research, 页码：5750-5758 , 文章类型： Article，,卷期：2010年16-23]
- Purpose: Overexpression of fibroblast growth factor receptor 2 (FGFR2) may be a causative factor of a number of human tumors, especially gastric tumors of the poorly differentiated type. We investigated whether monoclona...
- Effects of Siltuximab on the IL-6-Induced Signaling Pathway in Ovarian Cancer
[作者：Guo, YQ; Nemeth, J; O'Brien, C; Susa, M; Liu, XZ; Zhang, Z; Choy, E; Mankin, H; Hornicek, F; Duan, ZF,期刊：Clinical Cancer Research, 页码：5759-5769 , 文章类型： Article，,卷期：2010年16-23]
- Purpose: To explore potential therapeutic strategies for interrupting the interleukin-6 (IL-6) signaling pathway, we measured IL-6 expression in ovarian cancer tissues, and evaluated the effects of a monoclonal anti-IL-6...
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