- Overcoming Persistent Dependency on Androgen Signaling after Progression to Castration-Resistant Prostate Cancer
[作者：Yamaoka, M; Hara, T; Kusaka, M,期刊：Clinical Cancer Research, 页码：4319-4324 , 文章类型： Article，,卷期：2010年16-17]
- Prostate cancer is the most common form of cancer in males in the United States, and the second leading cause of cancer death. Initially, most cases of prostate cancer respond well to hormone therapy; however, resistance...
- PI(3)King Apart PTEN's Role in Cancer
[作者：Zhang, SY; Yu, DH,期刊：Clinical Cancer Research, 页码：4325-4330 , 文章类型： Article，,卷期：2010年16-17]
- The tumor suppressor phosphatase and tensin homolog (PTEN) is a nonredundant phosphatase, counteracting one of the most critical cancer-promoting pathways: the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. ...
- US Food and Drug Administration Approval: Ofatumumab for the Treatment of Patients with Chronic Lymphocytic Leukemia Refractory to Fludarabine and Alemtuzumab
[作者：Lemery, SJ; Zhang, J; Rothmann, MD; Yang, J; Earp, J; Zhao, H; McDougal, A; Pilaro, A; Chiang, R; Gootenberg, JE; Keegan, P; Pazdur, R,期刊：Clinical Cancer Research, 页码：4331-4338 , 文章类型： Article，,卷期：2010年16-17]
- Purpose: To describe the data and analyses that led to the U. S. Food and Drug Administration (FDA) approval of ofatumumab (Arzerra, GlaxoSmithKline) for the treatment of patients with chronic lymphocytic leukemia (CLL) ...
- Transcriptional Profiling of Polycythemia Vera Identifies Gene Expression Patterns Both Dependent and Independent from the Action of JAK2V617F
[作者：Berkofsky-Fessler, W; Buzzai, M; Kim, MKH; Fruchtman, S; Najfeld, V; Min, DJ; Costa, FF; Bischof, JM; Soares, MB; McConnell, MJ; Zhang, WJ; Levine, R; Gilliland, DG; Calogero, R; Licht, JD,期刊：Clinical Cancer Research, 页码：4339-4352 , 文章类型： Article，,卷期：2010年16-17]
- Purpose: To understand the changes in gene expression in polycythemia vera (PV) progenitor cells and their relationship to JAK2V617F. Experimental Design: Messenger RNA isolated from CD34(+) cells from nine PV patients a...
- Meta-analysis of Neuroblastomas Reveals a Skewed ALK Mutation Spectrum in Tumors with MYCN Amplification
[作者：De Brouwer, S; De Preter, K; Kumps, C; Zabrocki, P; Porcu, M; Westerhout, EM; Lakeman, A; Vandesompele, J; Hoebeeck, J; Van Maerken, T; De Paepe, A; Laureys, G; Schulte, JH; Schramm, A; Van den Broecke, C; Vermeulen, J; Van Roy, N; Beiske, K; Renard, M; Noguera, R; Delattre, O; Janoueix-Lerosey, I; Kogner, P; Martinsson, T; Nakagawara, A; Ohira, M; Caron, H; Eggert, A; Cools, J; Versteeg, R; Speleman, F,期刊：Clinical Cancer Research, 页码：4353-4362 , 文章类型： Article，,卷期：2010年16-17]
- Purpose: Activating mutations of the anaplastic lymphoma kinase (ALK) were recently described in neuroblastoma. We carried out a meta-analysis of 709 neuroblastoma tumors to determine their frequency and mutation spectru...
- Upregulation of SOX9 in Lung Adenocarcinoma and Its Involvement in the Regulation of Cell Growth and Tumorigenicity
[作者：Jiang, SS; Fang, WT; Hou, YH; Huang, SF; Yen, BL; Chang, JL; Li, SM; Liu, HP; Liu, YL; Huang, CT; Li, YW; Jang, TH; Chan, SH; Yang, SJ; Hsiung, CA; Wu, CW; Wang, LH; Chang, IS,期刊：Clinical Cancer Research, 页码：4363-4373 , 文章类型： Article，,卷期：2010年16-17]
- Purpose: SOX9 is an important transcription factor required for development and has been implicated in several types of cancer. However, SOX9 has never been linked to lung cancer to date. Here, we show that SOX9 expressi...
- The Relationship between Prostate-Specific Antigen and Prostate Cancer Risk: The Prostate Biopsy Collaborative Group
[作者：Vickers, AJ; Cronin, AM; Roobol, MJ; Hugosson, J; Jones, JS; Kattan, MW; Klein, E; Hamdy, F; Neal, D; Donovan, J; Parekh, DJ; Ankerst, D; Bartsch, G; Klocker, H; Horninger, W; Benchikh, A; Salama, G; Villers, A; Freedland, SJ; Moreira, DM; Schroder, FH; Lilja, H,期刊：Clinical Cancer Research, 页码：4374-4381 , 文章类型： Article，,卷期：2010年16-17]
- Purpose: The relationship between prostate-specific antigen (PSA) level and prostate cancer risk remains subject to fundamental disagreements. We hypothesized that the risk of prostate cancer on biopsy for a given PSA le...
- Induction of B-Chronic Lymphocytic Leukemia Cell Apoptosis by Arsenic Trioxide Involves Suppression of the Phosphoinositide 3-Kinase/Akt Survival Pathway via c-jun-NH2 Terminal Kinase Activation and PTEN Upregulation
[作者：Redondo-Munoz, J; Escobar-Diaz, E; del Cerro, MH; Pandiella, A; Terol, MJ; Garcia-Marco, JA; Garcia-Pardo, A,期刊：Clinical Cancer Research, 页码：4382-4391 , 文章类型： Article，,卷期：2010年16-17]
- Purpose: Arsenic trioxide (ATO) induces B-cell chronic lymphocytic leukemia (B-CLL) cell apoptosis in vitro. We sought to study the mechanism involved in this effect and whether ATO is suitable for combination therapies ...
- Neurotensin Receptor 1 Determines the Outcome of Non-Small Cell Lung Cancer
[作者：Alifano, M; Souaze, F; Dupouy, S; Camilleri-Broet, S; Younes, M; Ahmed-Zaid, SM; Takahashi, T; Cancellieri, A; Damiani, S; Boaron, M; Broet, P; Miller, LD; Gespach, C; Regnard, JF; Forgez, P,期刊：Clinical Cancer Research, 页码：4401-4410 , 文章类型： Article，,卷期：2010年16-17]
- Purpose: This study aimed to investigate the role of the neurotensin/neurotensin receptor I (NTSR1) complex in non-small cell lung cancer (NSCLC) progression. Experimental Design: The expression of neurotensin and NTSR1 ...
- Notch1 Expression Predicts an Unfavorable Prognosis and Serves as a Therapeutic Target of Patients with Neuroblastoma
[作者：Chang, HH; Lee, H; Hu, MK; Tsao, PN; Juan, HF; Huang, MC; Shih, YY; Wang, BJ; Jeng, YM; Chang, CL; Huang, SF; Tsay, YG; Hsieh, FJ; Lin, KH; Hsu, WM; Liao, YF,期刊：Clinical Cancer Research, 页码：4411-4420 , 文章类型： Article，,卷期：2010年16-17]
- Purpose: Notch signaling has been implicated to play a critical role in the tumorigenesis of neuroblastoma (NB) and can modulate calreticulin (CRT) expression that strongly correlates with tumor differentiation and favor...
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