- A Novel Chemoimmunomodulating Property of Docetaxel: Suppression of Myeloid-Derived Suppressor Cells in Tumor Bearers
[作者:Kodumudi, KN; Woan, K; Gilvary, DL; Sahakian, E; Wei, S; Djeu, JY,期刊:Clinical Cancer Research, 页码:4583-4594 , 文章类型: Article,,卷期:2010年16-18]
- Purpose: Myeloid-derived suppressor cells (MDSC) accumulate in tumor-bearing hosts and are associated with immune suppression. To date, there have only been few studies that evaluate the direct effect of chemotherapeutic...
- Inhibitory Effect of Silibinin against Azoxymethane-Induced Colon Tumorigenesis in A/J Mice
[作者:Ravichandran, K; Velmurugan, B; Gu, M; Singh, RP; Agarwal, R,期刊:Clinical Cancer Research, 页码:4595-4606 , 文章类型: Article,,卷期:2010年16-18]
- Purpose: Colorectal cancer is the second leading cause of cancer-associated deaths, which suggests that more effort is needed to prevent/control this disease. Herein, for the first time, we investigate in vivo the effica...
- Assessment of Vaccine-Induced CD4 T Cell Responses to the 119-143 Immunodominant Region of the Tumor-Specific Antigen NY-ESO-1 Using DRB1*0101 Tetramers
[作者:Ayyoub, M; Pignon, P; Dojcinovic, D; Raimbaud, I; Old, LJ; Luescher, I; Valmori, D,期刊:Clinical Cancer Research, 页码:4607-4615 , 文章类型: Article,,卷期:2010年16-18]
- Purpose: NY-ESO-1 (ESO), a tumor-specific antigen of the cancer/testis group, is presently viewed as an important model antigen for the development of generic anticancer vaccines. The ESO119-143 region is immunodominant ...
- Impact of Serum Hepatocyte Growth Factor on Treatment Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with Non-Small Cell Lung Adenocarcinoma
[作者:Kasahara, K; Arao, T; Sakai, K; Matsumoto, K; Sakai, A; Kimura, H; Sone, T; Horiike, A; Nishio, M; Ohira, T; Ikeda, N; Yamanaka, T; Saijo, N; Nishio, K,期刊:Clinical Cancer Research, 页码:4616-4624 , 文章类型: Article,,卷期:2010年16-18]
- Purpose: The epidermal growth factor receptor (EGFR) mutation status has emerged as a validated biomarker for predicting the response to treatment with EGFR-tyrosine kinase inhibitors (EGFR-TKI) in patients with non-smal...
- Correlated Expression of CD47 and SIRPA in Bone Marrow and in Peripheral Blood Predicts Recurrence in Breast Cancer Patients
[作者:Nagahara, M; Mimori, K; Kataoka, A; Ishii, H; Tanaka, F; Nakagawa, T; Sato, T; Ono, S; Sugihara, K; Mori, M,期刊:Clinical Cancer Research, 页码:4625-4635 , 文章类型: Article,,卷期:2010年16-18]
- Purpose: CD47 plays a variety of roles in intercellular signaling. Herein, we focused on the clinicopathologic significance of CD47 expression in human breast cancer. Our data suggest that the correlation between CD47 an...
- Jumonji Domain Containing 1A Is a Novel Prognostic Marker for Colorectal Cancer: In vivo Identification from Hypoxic Tumor Cells
[作者:Uemura, M; Yamamoto, H; Takemasa, I; Mimori, K; Hemmi, H; Mizushima, T; Ikeda, M; Sekimoto, M; Matsuura, N; Doki, Y; Mori, M,期刊:Clinical Cancer Research, 页码:4636-4646 , 文章类型: Article,,卷期:2010年16-18]
- Purpose: This study aimed to identify novel hypoxia-inducible and prognostic markers in vivo from hypoxic tumor cells. Experimental Design: Using carbonic anhydrase 9 and CD34 as a guide for hypoxic tumor cells, laser ca...
- A Pilot Study of Volume Measurement as a Method of Tumor Response Evaluation to Aid Biomarker Development
[作者:Zhao, BS; Oxnard, GR; Moskowitz, CS; Kris, MG; Pao, W; Guo, PZ; Rusch, VM; Ladanyi, M; Rizvi, NA; Schwartz, LH,期刊:Clinical Cancer Research, 页码:4647-4653 , 文章类型: Article,,卷期:2010年16-18]
- Purpose: Tissue biomarker discovery is potentially limited by conventional tumor measurement techniques, which have an uncertain ability to accurately distinguish sensitive and resistant tumors. Semiautomated volumetric ...
- Molecular Analysis of Non-Small Cell Lung Cancer Identifies Subsets with Different Sensitivity to Insulin-like Growth Factor I Receptor Inhibition
[作者:Gualberto, A; Dolled-Filhart, M; Gustavson, M; Christiansen, J; Wang, YF; Hixon, ML; Reynolds, J; McDonald, S; Ang, A; Rimm, DL; Langer, CJ; Blakely, J; Garland, L; Paz-Ares, LG; Karp, DD; Lee, AV,期刊:Clinical Cancer Research, 页码:4654-4665 , 文章类型: Article,,卷期:2010年16-18]
- Purpose: This study aimed to identify molecular determinants of sensitivity of non-small cell lung cancer (NSCLC) to anti-insulin-like growth factor receptor (IGF-IR) therapy. Experimental Design: A total of 216 tumor sa...
- An Open-Label, Phase I Study of the Polo-like Kinase-1 Inhibitor, BI 2536, in Patients with Advanced Solid Tumors
[作者:Hofheinz, RD; Al-Batran, SE; Hochhaus, A; Jager, E; Reichardt, VL; Fritsch, H; Trommeshauser, D; Munzert, G,期刊:Clinical Cancer Research, 页码:4666-4674 , 文章类型: Article,,卷期:2010年16-18]
- Purpose: This phase I, open-label, dose-escalation study investigated the maximum tolerated dose (MTD) of BI 2536, a small-molecule polo-like kinase (Plk)-1 inhibitor, in two treatment schedules in patients with advanced...
- Expression of Receptors for Luteinizing Hormone-Releasing Hormone (LH-RH) in Prostate Cancers following Therapy with LH-RH Agonists
[作者:Liu, SV; Schally, AV; Hawes, D; Xiong, SG; Fazli, L; Gleave, M; Cai, J; Groshen, S; Brands, F; Engel, J; Pinski, J,期刊:Clinical Cancer Research, 页码:4675-4680 , 文章类型: Article,,卷期:2010年16-18]
- Purpose: In addition to their expression on pituitary cells, receptors for luteinizing hormone-releasing hormone (LH-RH) are found on most prostate cancer cells. These tumoral LH-RH receptors mediate the direct cytotoxic...
- Targeting Cell Division Cycle 7 Kinase: A New Approach for Cancer Therapy
[作者:Montagnoli, A; Moll, J; Colotta, F,期刊:Clinical Cancer Research, 页码:4503-4508 , 文章类型: Article,,卷期:2010年16-18]
- The cell division cycle 7 (Cdc7) is a serine-threonine kinase, originally discovered in budding yeast, required to initiate DNA replication. Human Cdc7 phosphorylates the minichromosome maintenance protein 2 (Mcm2), a co...
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