- Location, Location, Location-Makes All the Difference for Hypoxia in Lung Tumors
[作者：Maity, A; Koumenis, C,期刊：Clinical Cancer Research, 页码：4685-4687 , 文章类型： Editorial Material，,卷期：2010年16-19]
- Hypoxia is a clinically important component of the tumor microenvironment because it adversely affects progression, metastasis, response to chemoradiation therapy, and overall patient survival. Here, we describe how diff...
- New Strategies in Hepatocellular Carcinoma: Genomic Prognostic Markers
[作者：Villanueva, A; Hoshida, Y; Toffanin, S; Lachenmayer, A; Alsinet, C; Savic, R; Cornella, H; Llovet, JM,期刊：Clinical Cancer Research, 页码：4688-4694 , 文章类型： Article，,卷期：2010年16-19]
- Accurate prognosis prediction in oncology is critical. In patients with hepatocellular carcinoma (HCC), unlike most solid tumors, the coexistence of two life-threatening conditions, cancer and cirrhosis, makes prognostic...
- Poly(ADP-Ribose) Polymerase Inhibition: "Targeted" Therapy for Triple-Negative Breast Cancer
[作者：Anders, CK; Winer, EP; Ford, JM; Dent, R; Silver, DP; Sledge, GW; Carey, LA,期刊：Clinical Cancer Research, 页码：4702-4710 , 文章类型： Review，,卷期：2010年16-19]
- In contrast to endocrine-sensitive and human epidermal growth factor receptor 2 (HER2)-positive breast cancer, novel agents capable of treating advanced triple-negative breast cancer (TNBC) are lacking. Poly (ADP-ribose)...
- Involvement of Human Herpesvirus-6 Variant B in Classic Hodgkin's Lymphoma via DR7 Oncoprotein
[作者：Lacroix, A; Collot-Teixeira, S; Mardivirin, L; Jaccard, A; Petit, B; Piguet, C; Sturtz, F; Preux, PM; Bordessoule, D; Ranger-Rogez, S,期刊：Clinical Cancer Research, 页码：4711-4721 , 文章类型： Article，,卷期：2010年16-19]
- Purpose: Hodgkin's lymphoma (HL) is associated with the presence of EBV in Reed-Sternberg (RS) cells in similar to 40% of cases. Here, we studied the presence of human herpesvirus type 6 (HHV-6) variant B in RS cells of ...
- Comprehensive Analysis of the MYB-NFIB Gene Fusion in Salivary Adenoid Cystic Carcinoma: Incidence, Variability, and Clinicopathologic Significance
[作者：Mitani, Y; Li, J; Rao, PH; Zhao, YJ; Bell, D; Lippman, SM; Weber, RS; Caulin, C; El-Naggar, AK,期刊：Clinical Cancer Research, 页码：4722-4731 , 文章类型： Article，,卷期：2010年16-19]
- Purpose: The objectives of this study were to determine the incidence of the MYB-NFIB fusion in salivary adenoid cystic carcinoma (ACC), to establish the clinicopathologic significance of the fusion, and to analyze the e...
- Hypoxia Inducible Factor 1 alpha and Hypoxia Inducible Factor 2 alpha Play Distinct and Functionally Overlapping Roles in Oral Squamous Cell Carcinoma
[作者：Zhu, GQ; Tang, YL; Li, L; Zheng, M; Jiang, J; Li, XY; Chen, SX; Liang, XH,期刊：Clinical Cancer Research, 页码：4732-4741 , 文章类型： Article，,卷期：2010年16-19]
- Purpose: This study aimed to investigate the functional difference between hypoxia inducible factor (HIF)-1 alpha and HIF-2 alpha in oral squamous cell carcinomas (OSCC). Experimental Design: We evaluated the correlation...
- Role of CAAT/Enhancer Binding Protein Homologous Protein in Panobinostat-Mediated Potentiation of Bortezomib-Induced Lethal Endoplasmic Reticulum Stress in Mantle Cell Lymphoma Cells
[作者：Rao, R; Nalluri, S; Fiskus, W; Savoie, A; Buckley, KM; Ha, K; Balusu, R; Joshi, A; Coothankandaswamy, V; Tao, JG; Sotomayor, E; Atadja, P; Bhalla, KN,期刊：Clinical Cancer Research, 页码：4742-4754 , 文章类型： Article，,卷期：2010年16-19]
- Purpose: Bortezomib induces unfolded protein response (UPR) and endoplasmic reticulum stress, as well as exhibits clinical activity in patients with relapsed and refractory mantle cell lymphoma (MCL). Here, we determined...
- Mitochondrial-Mediated Apoptosis in Lymphoma Cells by the Diterpenoid Lactone Andrographolide, the Active Component of Andrographis paniculata
[作者：Yang, S; Evens, AM; Prachand, S; Singh, ATK; Bhalla, S; David, K; Gordon, LI,期刊：Clinical Cancer Research, 页码：4755-4768 , 文章类型： Article，,卷期：2010年16-19]
- Purpose: Andrographolide is a diterpenoid lactone isolated from Andrographis paniculata (King of Bitters), an herbal medicine used in Asia. It has been reported to have anti-inflammatory, antihypertensive, antiviral, and...
- Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer
[作者：Junutula, JR; Flagella, KM; Graham, RA; Parsons, KL; Ha, E; Raab, H; Bhakta, S; Nguyen, T; Dugger, DL; Li, GM; Mai, E; Phillips, GDL; Hiraragi, H; Fuji, RN; Tibbitts, J; Vandlen, R; Spencer, SD; Scheller, RH; Polakis, P; Sliwkowski, MX,期刊：Clinical Cancer Research, 页码：4769-4778 , 文章类型： Article，,卷期：2010年16-19]
- Purpose: Antibody drug conjugates (ADCs) combine the ideal properties of both antibodies and cytotoxic drugs by targeting potent drugs to the antigen-expressing tumor cells, thereby enhancing their antitumor activity. Su...
- Preclinical Characterization of Mitochondria-Targeted Small Molecule Hsp90 Inhibitors, Gamitrinibs, in Advanced Prostate Cancer
[作者：Kang, BH; Siegelin, MD; Plescia, J; Raskett, CM; Garlick, DS; Dohi, T; Lian, JB; Stein, GS; Languino, LR; Altieri, DC,期刊：Clinical Cancer Research, 页码：4779-4788 , 文章类型： Article，,卷期：2010年16-19]
- Purpose: This study aimed to characterize the preclinical activity of the first class of combinatorial, mitochondria-targeted, small molecule heat shock protein-90 (Hsp90) inhibitors, gamitrinibs, in models of hormone-re...
- Cisplatin-Induced Downregulation of OCTN2 Affects Carnitine Wasting
[作者：Lancaster, CS; Hu, CX; Franke, RM; Filipski, KK; Orwick, SJ; Chen, ZY; Zuo, ZL; Loos, WJ; Sparreboom, A,期刊：Clinical Cancer Research, 页码：4789-4799 , 文章类型： Article，,卷期：2010年16-19]
- Purpose: Carnitine is an essential cofactor for mitochondrial fatty acid oxidation that is actively reabsorbed by the luminal transporter Octn2 (Slc22a5). Because the nephrotoxic agent cisplatin causes urinary loss of ca...
- Superior Efficacy of Tumor Cell Vaccines Grown in Physiologic Oxygen
[作者：Olin, MR; Andersen, BM; Zellmer, DM; Grogan, PT; Popescu, FE; Xiong, ZM; Forster, CL; Seiler, C; SantaCruz, KS; Chen, W; Blazar, BR; Ohlfest, JR,期刊：Clinical Cancer Research, 页码：4800-4808 , 文章类型： Article，,卷期：2010年16-19]
- Purpose: Atmospheric oxygen (similar to 20% O-2) has been the universal condition employed to culture tumor cells used as vaccine antigen. We tested the hypothesis that reducing oxygen tension would increase the efficacy...
- Tumor Regression and Curability of Preclinical Neuroblastoma Models by PEGylated SN38 (EZN-2208), a Novel Topoisomerase I Inhibitor
[作者：Pastorino, F; Loi, M; Sapra, P; Becherini, P; Cilli, M; Emionite, L; Ribatti, D; Greenberger, LM; Horak, ID; Ponzoni, M,期刊：Clinical Cancer Research, 页码：4809-4821 , 文章类型： Article，,卷期：2010年16-19]
- Purpose: Treatment of neuroblastoma is successful in less than half of patients with high-risk disease. The antitumor activity of a water soluble pegylated SN38 drug conjugate, EZN-2208, was compared with CPT-11 (a prodr...
- Detailed Distribution of NK012, an SN-38-Incorporating Micelle, in the Liver and Its Potent Antitumor Effects in Mice Bearing Liver Metastases
[作者：Takahashi, A; Ohkohchi, N; Yasunaga, M; Kuroda, J; Koga, Y; Kenmotsu, H; Kinoshita, T; Matsumura, Y,期刊：Clinical Cancer Research, 页码：4822-4831 , 文章类型： Article，,卷期：2010年16-19]
- Purpose: To clarify and compare the antitumor effects and specific biodistribution of NK012, an SN-38-incorporating polymeric micelle, in mice bearing multiple liver metastases of human colon cancer HT-29 cells with irin...
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