- Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients
[作者：Jacobs, JFM; Punt, CJA; Lesterhuis, WJ; Sutmuller, RPM; Brouwer, HMLH; Scharenborg, NM; Klasen, IS; Hilbrands, LB; Figdor, CG; de Vries, IJM; Adema, GJ,期刊：Clinical Cancer Research, 页码：5067-5078 , 文章类型： Article，,卷期：2010年16-20]
- Purpose: The success of cancer immunotherapy depends on the balance between effector T cells and suppressive immune regulatory mechanisms within the tumor microenvironment. In this study we investigated whether transient...
- A Phase I/II Trial Combining High-Dose Melphalan and Autologous Transplant with Bortezomib for Multiple Myeloma: A Dose- and Schedule-Finding Study
[作者：Lonial, S; Kaufman, J; Tighiouart, M; Nooka, A; Langston, AA; Heffner, LT; Torre, C; McMillan, S; Renfroe, H; Harvey, RD; Lechowicz, MJ; Khoury, HJ; Flowers, CR; Waller, EK,期刊：Clinical Cancer Research, 页码：5079-5086 , 文章类型： Article，,卷期：2010年16-20]
- Purpose: We did a randomized phase I/II trial designed to evaluate the safety and efficacy of combining the proteasome inhibitor bortezomib with high-dose melphalan as the conditioning for high-dose therapy and autologou...
- The Tissue Is the Issue: Personalized Medicine for Non-Small Cell Lung Cancer
[作者：Hirsch, FR; Wynes, MW; Gandara, DR; Bunn, PA,期刊：Clinical Cancer Research, 页码：4909-4911 , 文章类型： Editorial Material，,卷期：2010年16-20]
- The development of molecular markers is crucial for improving therapy in advanced non-small cell lung cancer (NSCLC). Here, we review perspectives of biomarker-driven personalized therapy in NSCLC, with particular refere...
- Folotyn (Pralatrexate Injection) for the Treatment of Patients with Relapsed or Refractory Peripheral T-Cell Lymphoma: U.S. Food and Drug Administration Drug Approval Summary
[作者：Malik, SM; Liu, K; Qiang, X; Sridhara, R; Tang, SH; McGuinn, WD; Verbois, SL; Marathe, A; Williams, GM; Bullock, J; Tornoe, C; Lin, SC; Ocheltree, T; Vialpando, M; Kacuba, A; Justice, R; Pazdur, R,期刊：Clinical Cancer Research, 页码：4921-4927 , 文章类型： Article，,卷期：2010年16-20]
- Purpose: On September 24, 2009, the U. S. Food and Drug Administration granted accelerated approval for Folotyn (pralatrexate injection, Allos Therapeutics, Inc.) as a single agent for the treatment of patients with rela...
- Key Role of Phosphoinositide 3-Kinase Class IB in Pancreatic Cancer
[作者：Edling, CE; Selvaggi, F; Buus, R; Maffucci, T; Di Sebastiano, P; Friess, H; Innocenti, P; Kocher, HM; Falasca, M,期刊：Clinical Cancer Research, 页码：4928-4937 , 文章类型： Article，,卷期：2010年16-20]
- Purpose: Phosphoinositide 3-kinase (PI3K) signaling is well established as important in cancer. To date most studies have been focused on the PI3K/p110 alpha isoform, which has been found to be mutated in several differe...
- EML4-ALK Fusion Gene Assessment Using Metastatic Lymph Node Samples Obtained by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration
[作者：Sakairi, Y; Nakajima, T; Yasufuku, K; Ikebe, D; Kageyama, H; Soda, M; Takeuchi, K; Itami, M; Iizasa, T; Yoshino, I; Mano, H; Kimura, H,期刊：Clinical Cancer Research, 页码：4938-4945 , 文章类型： Article，,卷期：2010年16-20]
- Purpose: Anaplastic lymphoma kinase (ALK) fusion genes represent novel oncogenes for non-small cell lung cancers (NSCLC). Several ALK inhibitors have been developed, and are now being evaluated in ALK-positive NSCLC. The...
- Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors
[作者：Hicks, KO; Siim, BG; Jaiswal, JK; Pruijn, FB; Fraser, AM; Patel, R; Hogg, A; Liyanage, HDS; Dorie, MJ; Brown, JM; Denny, WA; Hay, MP; Wilson, WR,期刊：Clinical Cancer Research, 页码：4946-4957 , 文章类型： Article，,卷期：2010年16-20]
- Purpose: Tirapazamine (TPZ) has attractive features for targeting hypoxic cells in tumors but has limited clinical activity, in part because of poor extravascular penetration. Here, we identify improved TPZ analogues by ...
- Novel Models of Myxoid Liposarcoma Xenografts Mimicking the Biological and Pharmacologic Features of Human Tumors
[作者：Frapolli, R; Tamborini, E; Virdis, E; Bello, E; Tarantino, E; Marchini, S; Grosso, F; Sanfilippo, R; Gronchi, A; Tercero, JC; Peloso, G; Casali, P; Pilotti, S; D'Incalci, M,期刊：Clinical Cancer Research, 页码：4958-4967 , 文章类型： Article，,卷期：2010年16-20]
- Purpose: Myxoid liposarcoma is a common subtype of liposarcoma. It is associated in more than 90% of cases with the chromosomal translocation t(12; 16)(q13; p11) leading to the fusion FUS-CHOP gene that is responsible fo...
- A Proteasome Inhibitor, Bortezomib, Inhibits Breast Cancer Growth and Reduces Osteolysis by Downregulating Metastatic Genes
[作者：Jones, MD; Liu, JC; Barthel, TK; Hussain, S; Lovria, E; Cheng, DF; Schoonmaker, JA; Mulay, S; Ayers, DC; Bouxsein, ML; Stein, GS; Mukherjee, S; Lian, JB,期刊：Clinical Cancer Research, 页码：4978-4989 , 文章类型： Article，,卷期：2010年16-20]
- Purpose: The incidence of bone metastasis in advanced breast cancer (BrCa) exceeds 70%. Bortezomib, a proteasome inhibitor used for the treatment of multiple myeloma, also promotes bone formation. We tested the hypothesi...
- Synergistic Antitumor Activity of Sorafenib in Combination with Epidermal Growth Factor Receptor Inhibitors in Colorectal and Lung Cancer Cells
[作者：Martinelli, E; Troiani, T; Morgillo, F; Rodolico, G; Vitagliano, D; Morelli, MP; Tuccillo, C; Vecchione, L; Capasso, A; Orditura, M; De Vita, F; Eckhardt, SG; Santoro, M; Berrino, L; Ciardiello, F,期刊：Clinical Cancer Research, 页码：4990-5001 , 文章类型： Article，,卷期：2010年16-20]
- Purpose: Cancer cell survival, invasion, and metastasis depend on cancer cell proliferation and on tumor-induced angiogenesis. We evaluated the efficacy of the combination of sorafenib and erlotinib or cetuximab. Experim...
- Portable Filter-Based Microdevice for Detection and Characterization of Circulating Tumor Cells
[作者：Lin, HK; Zheng, SY; Williams, AJ; Balic, M; Groshen, S; Scher, HI; Fleisher, M; Stadler, W; Datar, RH; Tai, YC; Cote, RJ,期刊：Clinical Cancer Research, 页码：5011-5018 , 文章类型： Article，,卷期：2010年16-20]
- Purpose: Sensitive detection and characterization of circulating tumor cells (CTC) could revolutionize the approach to patients with early-stage and metastatic cancer. The current methodologies have significant limitatio...
- No Evidence of Sex-Related Survival Disparities among Head and Neck Cancer Patients Receiving Similar Multidisciplinary Care: A Matched-Pair Analysis
[作者：Roberts, JC; Li, GJ; Reitzel, LR; Wei, QY; Sturgis, EM,期刊：Clinical Cancer Research, 页码：5019-5027 , 文章类型： Article，,卷期：2010年16-20]
- Purpose: It is unknown whether there are survival disparities between men and women with squamous cell carcinoma of the head and neck (SCCHN), although some data suggest that men have worse outcomes. We conducted a match...
|