- Differential Gene Expression in Benign Prostate Epithelium of Men with and without Prostate Cancer: Evidence for a Prostate Cancer Field Effect
[作者:Risk, MC; Knudsen, BS; Coleman, I; Dumpit, RF; Kristal, AR; LeMeur, N; Gentleman, RC; True, LD; Nelson, PS; Lin, DW,期刊:Clinical Cancer Research, 页码:5414-5423 , 文章类型: Article,,卷期:2010年16-22]
- Background: Several malignancies are known to exhibit a "field effect," whereby regions beyond tumor boundaries harbor histologic or molecular changes that are associated with cancer. We sought to determine if histologic...
- Dual Inhibition of PI3K and mTORC1/2 Signaling by NVP-BEZ235 as a New Therapeutic Strategy for Acute Myeloid Leukemia
[作者:Chapuis, N; Tamburini, J; Green, AS; Vignon, C; Bardet, V; Neyret, A; Pannetier, M; Willems, L; Park, S; Macone, A; Maira, SM; Ifrah, N; Dreyfus, F; Herault, O; Lacombe, C; Mayeux, P; Bouscary, D,期刊:Clinical Cancer Research, 页码:5424-5435 , 文章类型: Article,,卷期:2010年16-22]
- Purpose: The growth and survival of acute myeloid leukemia (AML) cells are enhanced by the deregulation of signaling pathways such as phosphoinositide 3-kinase (PI3K)/Akt and mammalian target of rapamycin (mTOR). Major e...
- The Insulin-like Growth Factor I Receptor/Insulin Receptor Tyrosine Kinase Inhibitor PQIP Exhibits Enhanced Antitumor Effects in Combination with Chemotherapy Against Colorectal Cancer Models
[作者:Flanigan, SA; Pitts, TM; Eckhardt, SG; Tentler, JJ; Tan, AC; Thorburn, A; Leong, S,期刊:Clinical Cancer Research, 页码:5436-5446 , 文章类型: Article,,卷期:2010年16-22]
- Purpose: There is growing evidence implicating the importance of the insulin-like growth factor (IGF) pathway in colorectal cancer based upon the results of population studies and preclinical experiments. However, the co...
- Development of a Validated Immunofluorescence Assay for gamma H2AX as a Pharmacodynamic Marker of Topoisomerase I Inhibitor Activity
[作者:Kinders, RJ; Hollingshead, M; Lawrence, S; Ji, JP; Tabb, B; Bonner, WM; Pommier, Y; Rubinstein, L; Evrard, YA; Parchment, RE; Tomaszewski, J; Doroshow, JH,期刊:Clinical Cancer Research, 页码:5447-5457 , 文章类型: Article,,卷期:2010年16-22]
- Purpose: Phosphorylated histone H2AX (gamma H2AX) serves as a biomarker for formation of DNA double-strand break repair complexes. A quantitative pharmacodynamic immunofluorescence assay for gamma H2AX was developed, val...
- Transduction of Tumor-Specific T Cells with CXCR2 Chemokine Receptor Improves Migration to Tumor and Antitumor Immune Responses
[作者:Peng, WY; Ye, Y; Rabinovich, BA; Liu, CW; Lou, YY; Zhang, MY; Whittington, M; Yang, Y; Overwijk, WW; Lizee, G; Hwu, P,期刊:Clinical Cancer Research, 页码:5458-5468 , 文章类型: Article,,卷期:2010年16-22]
- Purpose: One of the most important rate-limiting steps in adoptive cell transfer (ACT) is the inefficient migration of T cells to tumors. Because melanomas specifically express the chemokines CXCL1 and CXCL8 that are kno...
- Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models
[作者:Santel, A; Aleku, M; Roder, N; Mopert, K; Durieux, B; Janke, O; Keil, O; Endruschat, J; Dames, S; Lange, C; Eisermann, M; Loffler, K; Fechtner, M; Fisch, G; Vank, C; Schaeper, U; Giese, K; Kaufmann, J,期刊:Clinical Cancer Research, 页码:5469-5480 , 文章类型: Article,,卷期:2010年16-22]
- Purpose: Atu027, a novel RNA interference therapeutic, has been shown to inhibit lymph node metastasis in orthotopic prostate cancer mouse models. The aim of this study is to elucidate the pharmacologic activity of Atu02...
- Eradication of Medullary Multiple Myeloma by CD4(+) Cytotoxic Human T Lymphocytes Directed at a Single Minor Histocompatibility Antigen
[作者:Spaapen, RM; Groen, RWJ; van den Oudenalder, K; Guichelaar, T; van Elk, M; Aarts-Riemens, T; Bloem, AC; Storm, G; Martens, AC; Lokhorst, HM; Mutis, T,期刊:Clinical Cancer Research, 页码:5481-5488 , 文章类型: Article,,卷期:2010年16-22]
- Purpose: The essential role of CD4(+) T cells as helpers of anticancer immunity is indisputable. Little is known, however, about their capacity to serve as effector cells in cancer treatment. Therefore, we explored the e...
- Reciprocal and Complementary Role of MET Amplification and EGFR T790M Mutation in Acquired Resistance to Kinase Inhibitors in Lung Cancer
[作者:Suda, K; Murakami, I; Katayama, T; Tomizawa, K; Osada, H; Sekido, Y; Maehara, Y; Yatabe, Y; Mitsudomi, T,期刊:Clinical Cancer Research, 页码:5489-5498 , 文章类型: Article,,卷期:2010年16-22]
- Purpose: In epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy for lung cancer patients, acquired resistance develops almost inevitably and this limits the improvement in patient outcomes. EG...
- Mechanisms of Synergistic Antileukemic Interactions between Valproic Acid and Cytarabine in Pediatric Acute Myeloid Leukemia
[作者:Xie, CZ; Edwards, H; Xu, XL; Zhou, H; Buck, SA; Stout, ML; Yu, Q; Rubnitz, JE; Matherly, LH; Taub, JW; Ge, YB,期刊:Clinical Cancer Research, 页码:5499-5510 , 文章类型: Article,,卷期:2010年16-22]
- Purpose: To determine the possibility of synergistic antileukemic activity and the underlying molecular mechanisms associated with cytarabine combined with valproic acid (VPA; a histone deacetylase inhibitor and a Food a...
- Overexpression of High-Mobility Group Box 2 Is Associated with Tumor Aggressiveness and Prognosis of Hepatocellular Carcinoma
[作者:Kwon, JH; Kim, J; Park, JY; Hong, SM; Park, CW; Hong, SJ; Park, SY; Choi, YJ; Do, IG; Joh, JW; Kim, DS; Choi, KY,期刊:Clinical Cancer Research, 页码:5511-5521 , 文章类型: Article,,卷期:2010年16-22]
- Purpose: We investigated the expression of high-mobility group box 2 (HMGB2) in patients with hepatocellular carcinoma (HCC) and its clinical effects with underlying mechanisms. Experimental Design: HMGB2 mRNA levels wer...
- Prognostic Significance of RNA-Dependent Protein Kinase on Non-Small Cell Lung Cancer Patients
[作者:Pataer, A; Raso, MG; Correa, AM; Behrens, C; Tsuta, K; Solis, L; Fang, BL; Roth, JA; Wistuba, II; Swisher, SG,期刊:Clinical Cancer Research, 页码:5522-5528 , 文章类型: Article,,卷期:2010年16-22]
- Purpose: The role of RNA-dependent protein kinase (PKR) in antiviral defense mechanisms and in cellular differentiation, growth, and apoptosis is well known, but the role of PKR in human lung cancer remains poorly unders...
- Expression, Cellular Distribution, and Prognostic Relevance of TRAIL Receptors in Hepatocellular Carcinoma
[作者:Kriegl, L; Jung, A; Engel, J; Jackstadt, R; Gerbes, AL; Gallmeier, E; Reiche, JA; Hermeking, H; Rizzani, A; Bruns, CJ; Kolligs, FT; Kirchner, T; Goke, B; De Toni, EN,期刊:Clinical Cancer Research, 页码:5529-5538 , 文章类型: Article,,卷期:2010年16-22]
- Purpose: After the advent of targeted therapies for hepatocellular carcinoma (HCC), much work is being done to provide a comprehensive description of the different signaling pathways contributing to cell survival and pro...
- Vaccination of Metastatic Renal Cancer Patients with MVA-5T4: A Randomized, Double-Blind, Placebo-Controlled Phase III Study
[作者:Amato, RJ; Hawkins, RE; Kaufman, HL; Thompson, JA; Tomczak, P; Szczylik, C; McDonald, M; Eastty, S; Shingler, WH; de Belin, J; Goonewardena, M; Naylor, S; Harrop, R,期刊:Clinical Cancer Research, 页码:5539-5547 , 文章类型: Article,,卷期:2010年16-22]
- Purpose: The TroVax Renal Immunotherapy Survival Trial was a randomized, placebo-controlled phase III study that investigated whether modified vaccinia Ankara encoding the tumor antigen 5T4 (MVA-5T4) prolonged survival o...
- A Randomized Trial of Ex vivo CD40L Activation of a Dendritic Cell Vaccine in Colorectal Cancer Patients: Tumor-Specific Immune Responses Are Associated with Improved Survival
[作者:Barth, RJ; Fisher, DA; Wallace, PK; Channon, JY; Noelle, RJ; Gui, JA; Ernstoff, MS,期刊:Clinical Cancer Research, 页码:5548-5556 , 文章类型: Article,,卷期:2010年16-22]
- Purpose: To determine whether an autologous dendritic cell (DC) vaccine could induce antitumor immune responses in patients after resection of colorectal cancer metastases and whether these responses could be enhanced by...
- REO-10: A Phase I Study of Intravenous Reovirus and Docetaxel in Patients with Advanced Cancer
[作者:Comins, C; Spicer, J; Protheroe, A; Roulstone, V; Twigger, K; White, CM; Vile, R; Melcher, A; Coffey, MC; Mettinger, KL; Nuovo, G; Cohn, DE; Phelps, M; Harrington, KJ; Pandha, HS,期刊:Clinical Cancer Research, 页码:5564-5572 , 文章类型: Article,,卷期:2010年16-22]
- Purpose: REOLYSIN (Oncolytics Biotech) consists of a wild-type oncolytic reovirus, which has selective cytotoxicity for tumor cells while sparing normal cells. In a phase I study as a single agent, repeated infusions of ...
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