- Clinical Responses in a Phase II Study Using Adoptive Transfer of Short-term Cultured Tumor Infiltration Lymphocytes in Metastatic Melanoma Patients
[作者:Besser, MJ; Shapira-Frommer, R; Treves, AJ; Zippel, D; Itzhaki, O; Hershkovitz, L; Levy, D; Kubi, A; Hovav, E; Chermoshniuk, N; Shalmon, B; Hardan, I; Catane, R; Markel, G; Apter, S; Ben-Nun, A; Kuchuk, I; Shimoni, A; Nagler, A; Schachter, J,期刊:Clinical Cancer Research, 页码:2646-2655 , 文章类型: Article,,卷期:2010年16-9]
- Purpose: Adoptive cell therapy with autologous tumor-infiltrating lymphocytes (TIL) has shown promising results in metastatic melanoma patients. Although objective response rates of over 50% have been reported, disadvant...
- Phase I and Pharmacokinetic Study of Sequential Paclitaxel and Trabectedin Every 2 Weeks in Patients with Advanced Solid Tumors
[作者:Chu, Q; Mita, A; Forouzesh, B; Tolcher, AW; Schwartz, G; Nieto, A; Soto-Matos, A; Alfaro, V; Lebedinsky, C; Rowinsky, EK,期刊:Clinical Cancer Research, 页码:2656-2665 , 文章类型: Article,,卷期:2010年16-9]
- Purpose: This phase I study evaluated the feasibility, safety, pharmacokinetics (PK), and preliminary evidence of anticancer activity of the sequential administration of paclitaxel and trabectedin on an every-2-week sche...
- Pharmacokinetic Analysis and Phase 1 Study of MRX-1024 in Patients Treated with Radiation Therapy with or without Cisplatinum for Head and Neck Cancer
[作者:Hamstra, DA; Eisbruch, A; Naidu, MUR; Ramana, GV; Sunkara, P; Campbell, KCM; Ross, BD; Rehemtulla, A,期刊:Clinical Cancer Research, 页码:2666-2676 , 文章类型: Article,,卷期:2010年16-9]
- Purpose: A previous study reported radiation protection from mucosal injury with D-methionine (D-met) in preclinical evaluation; therefore, the pharmacokinetics, safety, and utility of D-met were evaluated clinically.Exp...
- A Phase Ib Study of AMG 102 in Combination with Bevacizumab or Motesanib in Patients with Advanced Solid Tumors
[作者:Rosen, PJ; Sweeney, CJ; Park, DJ; Beaupre, DM; Deng, HJ; Leitch, IM; Shubhakar, P; Zhu, M; Oliner, KS; Anderson, A; Yee, LK,期刊:Clinical Cancer Research, 页码:2677-2687 , 文章类型: Article,,卷期:2010年16-9]
- Purpose: This phase Ib study evaluated the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of AMG 102, a fully human monoclonal antibody against hepatocyte growth factor/scatter factor (HGF/SF), in com...
- Clinical Benefit of Lapatinib-Based Therapy in Patients with Human Epidermal Growth Factor Receptor 2-Positive Breast Tumors Coexpressing the Truncated p95HER2 Receptor
[作者:Scaltriti, M; Chandarlapaty, S; Prudkin, L; Aura, C; Jimenez, J; Angelini, PD; Sanchez, G; Guzman, M; Parra, JL; Ellis, C; Gagnon, R; Koehler, M; Gomez, H; Geyer, C; Cameron, D; Arribas, J; Rosen, N; Baselga, J,期刊:Clinical Cancer Research, 页码:2688-2695 , 文章类型: Article,,卷期:2010年16-9]
- Purpose: A subgroup of human epidermal growth factor receptor 2 (HER2)-overexpressing breast tumors coexpresses p95HER2, a truncated HER2 receptor that retains a highly functional HER2 kinase domain but lacks the extrace...
- Combined Functional Genome Survey of Therapeutic Targets for Hepatocellular Carcinoma
[作者:Satow, R; Shitashige, M; Kanai, Y; Takeshita, F; Ojima, H; Jigami, T; Honda, K; Kosuge, T; Ochiya, T; Hirohashi, S; Yamada, T,期刊:Clinical Cancer Research, 页码:2518-2528 , 文章类型: Article,,卷期:2010年16-9]
- Purpose: The outcome of patients with advanced hepatocellular carcinoma (HCC) has remained unsatisfactory. Patients with HCC suffer from chronic hepatitis or liver cirrhosis, and their reserve liver function is often lim...
- Targeted Chemotherapy for Head and Neck Cancer with a Chimeric Oncolytic Adenovirus Coding for Bifunctional Suicide Protein FCU1
[作者:Dias, JD; Liikanen, I; Guse, K; Foloppe, J; Sloniecka, M; Diaconu, I; Rantanen, V; Eriksson, M; Hakkarainen, T; Lusky, M; Erbs, P; Escutenaire, S; Kanerva, A; Pesonen, S; Cerullo, V; Hemminki, A,期刊:Clinical Cancer Research, 页码:2540-2549 , 文章类型: Article,,卷期:2010年16-9]
- Purpose: Transfer of prodrug activation systems into tumors by using replication-deficient viruses has been suggested to be an effective method for achieving high local and low systemic anticancer drug concentrations. Ho...
- Inhibition of p-STAT3 Enhances IFN-alpha Efficacy against Metastatic Melanoma in a Murine Model
[作者:Kong, LY; Gelbard, A; Wei, J; Reina-Ortiz, C; Wang, YT; Yang, EC; Hailemichael, Y; Fokt, I; Jayakumar, A; Qiao, W; Fuller, GN; Overwijk, WW; Priebe, W; Heimberger, AB,期刊:Clinical Cancer Research, 页码:2550-2561 , 文章类型: Article,,卷期:2010年16-9]
- Purpose: Melanoma is a common and deadly tumor that upon metastasis to the central nervous system has a median survival duration of <6 months. Activation of the signal transducer and activator of transcription 3 (STAT3) ...
- EphA2 Targeted Chemotherapy Using an Antibody Drug Conjugate in Endometrial Carcinoma
[作者:Lee, JW; Stone, RL; Lee, SJ; Nam, EJ; Roh, JW; Nick, AM; Han, HD; Shahzad, MMK; Kim, HS; Mangala, LS; Jennings, NB; Mao, SL; Gooya, J; Jackson, D; Coleman, RL; Sood, AK,期刊:Clinical Cancer Research, 页码:2562-2570 , 文章类型: Article,,卷期:2010年16-9]
- Purpose: EphA2 overexpression is frequently observed in endometrial cancers and is predictive of poor clinical outcome. Here, we use an antibody drug conjugate (MEDI-547) composed of a fully human monoclonal antibody aga...
- Honokiol Inhibits Epidermal Growth Factor Receptor Signaling and Enhances the Antitumor Effects of Epidermal Growth Factor Receptor Inhibitors
[作者:Leeman-Neill, RJ; Cai, QA; Joyce, SC; Thomas, SM; Bhola, NE; Neill, DB; Arbiser, JL; Grandis, JR,期刊:Clinical Cancer Research, 页码:2571-2579 , 文章类型: Article,,卷期:2010年16-9]
- Purpose: This study aimed to investigate the utility of honokiol, a naturally occurring compound, in the treatment of head and neck squamous cell carcinoma (HNSCC) as well as its ability to target the epidermal growth fa...
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