- Telomere Maintenance and DNA Damage Responses during Lung Carcinogenesis
[作者：Lantuejoul, S; Raynaud, C; Salameire, D; Gazzeri, S; Moro-Sibilot, D; Soria, JC; Brambilla, C; Brambilla, E,期刊：Clinical Cancer Research, 页码：2979-2988 , 文章类型： Article，,卷期：2010年16-11]
- Purpose: Telomere shortening is an early event in bronchial carcinogenesis, preceding P53/Rb pathway inactivation and telomerase reactivation, and leading to DNA damage responses (DDR). As their inactivation in cancer in...
- Assessment of the In vivo Antitumor Effects of ENMD-2076, a Novel Multitargeted Kinase Inhibitor, against Primary and Cell Line-Derived Human Colorectal Cancer Xenograft Models
[作者：Tentler, JJ; Bradshaw-Pierce, EL; Serkova, NJ; Hasebroock, KM; Pitts, TM; Diamond, JR; Fletcher, GC; Bray, MR; Eckhardt, SG,期刊：Clinical Cancer Research, 页码：2989-2998 , 文章类型： Article，,卷期：2010年16-11]
- Purpose: This in vivo study was designed to investigate the efficacy of ENMD-2076, a small-molecule kinase inhibitor with activity against the Aurora kinases A and B, and several other tyrosine kinases linked to cancer, ...
- Insulin-like Growth Factor 2 Expression Modulates Taxol Resistance and Is a Candidate Biomarker for Reduced Disease-Free Survival in Ovarian Cancer
[作者：Huang, GS; Brouwer-Visser, J; Ramirez, MJ; Kim, CH; Hebert, TM; Lin, J; Arias-Pulido, H; Qualls, CR; Prossnitz, ER; Goldberg, GL; Smith, HO; Horwitz, SB,期刊：Clinical Cancer Research, 页码：2999-3010 , 文章类型： Article，,卷期：2010年16-11]
- Purpose: This study was undertaken to examine the role of the insulin-like growth factor (IGF) signaling pathway in the response of ovarian cancer cells to Taxol and to evaluate the significance of this pathway in human ...
- Fibroblast Growth Factor Receptor 3 Mutation Analysis on Voided Urine for Surveillance of Patients with Low-Grade Non-Muscle-Invasive Bladder Cancer
[作者：Zuiverloon, TCM; van der Aa, MNM; van der Kwast, TH; Steyerberg, EW; Lingsma, HF; Bangma, CH; Zwarthoff, EC,期刊：Clinical Cancer Research, 页码：3011-3018 , 文章类型： Article，,卷期：2010年16-11]
- Purpose: Mutations in the fibroblast growth factor receptor 3 (FGFR3) have been found in 70% of the low-grade non-muscle-invasive bladder cancer (NMI-BC) tumors. We aim to determine the potential of FGFR3 mutation analys...
- A Phase I Study of 5-Fluorouracil/Leucovorin and Arsenic Trioxide for Patients with Refractory/Relapsed Colorectal Carcinoma
[作者：Ardalan, B; Subbarayan, PR; Ramos, Y; Gonzalez, M; Fernandez, A; Mezentsev, D; Reis, I; Duncan, R; Podolsky, L; Lee, K; Lima, M; Ganjei-Azar, P,期刊：Clinical Cancer Research, 页码：3019-3027 , 文章类型： Article，,卷期：2010年16-11]
- Purpose: This Phase I study was designed to determine a safe combination dose of 5-fluorouracil (5-FU) and arsenic trioxide (ATO) to treat 5-FU-resistant relapsed/refractory colorectal cancer patients. We studied the eff...
- Clinical and Correlative Results of SWOG S0354: A Phase II Trial of CNTO328 (Siltuximab), a Monoclonal Antibody against Interleukin-6, in Chemotherapy-Pretreated Patients with Castration-Resistant Prostate Cancer
[作者：Dorff, TB; Goldman, B; Pinski, JK; Mack, PC; Lara, PN; Van Veldhuizen, PJ; Quinn, DI; Vogelzang, NJ; Thompson, IM; Hussain, MHA,期刊：Clinical Cancer Research, 页码：3028-3034 , 文章类型： Article，,卷期：2010年16-11]
- Purpose: Interleukin-6 (IL-6) facilitates cancer cell survival via pleotrophic effects. We conducted a multicenter phase II study of CNTO328 (siltuximab) as second-line therapy for men with castration-resistant prostate ...
- Oncolytic Adenovirus ICOVIR-7 in Patients with Advanced and Refractory Solid Tumors
[作者：Nokisalmi, P; Pesonen, S; Escutenaire, S; Sarkioja, M; Raki, M; Cerullo, V; Laasonen, L; Alemany, R; Rojas, J; Cascallo, M; Guse, K; Rajecki, M; Kangasniemi, L; Haavisto, E; Karioja-Kallio, A; Hannuksela, P; Oksanen, M; Kanerva, A; Joensuu, T; Ahtiainen, L; Hemminki, A,期刊：Clinical Cancer Research, 页码：3035-3043 , 文章类型： Article，,卷期：2010年16-11]
- Purpose: Twenty-one patients with cancer were treated with a single round of oncolytic adenovirus ICOVIR-7.Experimental Design: ICOVIR-7 features an RGD-4C modification of the fiber HI-loop of serotype 5 adenovirus for e...
- Phase 1 Study of AMG 386, a Selective Angiopoietin 1/2-Neutralizing Peptibody, in Combination with Chemotherapy in Adults with Advanced Solid Tumors
[作者：Mita, AC; Takimoto, CH; Mita, M; Tolcher, A; Sankhala, K; Sarantopoulos, J; Valdivieso, M; Wood, L; Rasmussen, E; Sun, YN; Zhong, ZD; Bass, MB; Le, N; LoRusso, P,期刊：Clinical Cancer Research, 页码：3044-3056 , 文章类型： Article，,卷期：2010年16-11]
- Purpose: To evaluate the safety, pharmacokinetics, and antitumor activity of AMG 386, an investigational selective angiopoietin 1/2-neutralizing peptibody, in combination with FOLFOX-4 (F), carboplatin/paclitaxel (C/P), ...
- A Pharmacodynamic Study of Rapamycin in Men with Intermediate- to High-Risk Localized Prostate Cancer
[作者：Armstrong, AJ; Netto, GJ; Rudek, MA; Halabi, S; Wood, DP; Creel, PA; Mundy, K; Davis, SL; Wang, T; Albadine, R; Schultz, L; Partin, AW; Jimeno, A; Fedor, H; Febbo, PG; George, DJ; Gurganus, R; De Marzo, AM; Carducci, MA,期刊：Clinical Cancer Research, 页码：3057-3066 , 文章类型： Article，,卷期：2010年16-11]
- Purpose: Given discrepancies between preclinical and clinical observations of mammalian target of rapamycin (mTOR) inhibition in prostate cancer, we sought to determine the pharmacodynamic effects of the mTOR/TORC1 inhib...
- Two-Stage Phase I Dose-Escalation Study of Intratumoral Reovirus Type 3 Dearing and Palliative Radiotherapy in Patients with Advanced Cancers
[作者：Harrington, KJ; Karapanagiotou, EM; Roulstone, V; Twigger, KR; White, CL; Vidal, L; Beirne, D; Prestwich, R; Newbold, K; Ahmed, M; Thway, K; Nutting, CM; Coffey, M; Harris, D; Vile, RG; Pandha, HS; DeBono, JS; Melcher, AA,期刊：Clinical Cancer Research, 页码：3067-3077 , 文章类型： Article，,卷期：2010年16-11]
- Purpose: To determine the safety and feasibility of combining intratumoral reovirus and radiotherapy in patients with advanced cancer and to assess viral biodistribution, reoviral replication in tumors, and antiviral imm...
- A Multicenter Phase II Study of Erlotinib and Sorafenib in Chemotherapy-Naive Patients with Advanced Non-Small Cell Lung Cancer
[作者：Lind, JSW; Dingemans, AMC; Groen, HJM; Thunnissen, FB; Bekers, O; Heideman, DAM; Honeywell, RJ; Giovannetti, E; Peters, GJ; Postmus, PE; van Suylen, RJ; Smit, EF,期刊：Clinical Cancer Research, 页码：3078-3087 , 文章类型： Article，,卷期：2010年16-11]
- Purpose: This multicenter, phase II study evaluates the efficacy and safety of erlotinib, an epidermal growth factor receptor (EGFR) inhibitor, plus sorafenib, a multityrosine kinase inhibitor against vascular endothelia...
- CXCL12 (SDF-1)/CXCR4 Pathway in Cancer
[作者：Teicher, BA; Fricker, SP,期刊：Clinical Cancer Research, 页码：2927-2931 , 文章类型： Article，,卷期：2010年16-11]
- Chemokines, small proinflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The chemokine CXCL12 [stromal...
- The Proapoptotic Molecule BLID Interacts with Bcl-X-L and Its Downregulation in Breast Cancer Correlates with Poor Disease-Free and Overall Survival
[作者：Broustas, CG; Ross, JS; Yang, QF; Sheehan, CE; Riggins, R; Noone, AM; Haddad, BR; Seillier-Moiseiwitsch, F; Kallakury, BVS; Haffty, BG; Clarke, R; Kasid, UN,期刊：Clinical Cancer Research, 页码：2939-2948 , 文章类型： Article，,卷期：2010年16-11]
- Purpose: BLID is a BH3-like motif containing apoptotic member of the Bcl-2 family of proteins. This study was designed to investigate the mechanism of BLID-induced apoptosis and to assess the significance of BLID express...
- The Tumor Suppressor UCHL1 Forms a Complex with p53/MDM2/ARF to Promote p53 Signaling and Is Frequently Silenced in Nasopharyngeal Carcinoma
[作者：Li, LL; Tao, Q; Jin, HC; van Hasselt, A; Poon, FF; Wang, XA; Zeng, MS; Jia, WH; Zeng, YX; Chan, ATC; Cao, Y,期刊：Clinical Cancer Research, 页码：2949-2958 , 文章类型： Article，,卷期：2010年16-11]
- Purpose: Nasopharyngeal carcinoma is prevalent in southern China and Southeast Asia, with distinct geographic and ethnic distribution. One candidate susceptibility locus has been identified at 4p11-14, with the associate...
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