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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共24条记录   AdCD40L Immunogene Therapy for Bladder Carcinoma-The First Phase I/IIa Trial [作者：Malmstrom, PU; Loskog, ASI; Lindqvist, CA; Mangsbo, SM; Fransson, M; Wanders, A; Gardmark, T; Totterman, TH,期刊：Clinical Cancer Research, 页码：3279-3287 , 文章类型： Article，,卷期：2010年16-12] Purpose: Immunotherapy with Bacillus Calmette-Guerin ( BCG) instillation is recommended for high-risk, non-muscle invasive bladder cancer. Bacillus Calmette-Guerin is not effective in advanced tumors, and better alternat... Imatinib Mesylate as a Preoperative Therapy in Dermatofibrosarcoma: Results of a Multicenter Phase II Study on 25 Patients [作者：Kerob, D; Porcher, R; Verola, O; Dalle, S; Maubec, E; Aubin, F; D'Incan, M; Bodokh, I; Boulinguez, S; Madelaine-Chambrin, I; Mathieu-Boue, A; Servant, JM; de Kerviler, E; Janin, A; Calvo, F; Pedeutour, F; Lebbe, C,期刊：Clinical Cancer Research, 页码：3288-3295 , 文章类型： Article，,卷期：2010年16-12] Aims: The treatment of dermatofibrosarcoma protuberans ( DFSP) involves wide local excision with frequent need for reconstructive surgery. A t(17;22) translocation resulting in COL1A1-PDGFB fusion is present in >95% of c... Inhibition of the PI3K Pathway: Hope We Can Believe in? [作者：van der Heijden, MS; Bernards, R,期刊：Clinical Cancer Research, 页码：3094-3099 , 文章类型： Article，,卷期：2010年16-12] The phosphoinositide 3-kinase ( PI3K) pathway is one of the most commonly activated pathways in human cancer and has roles in cell proliferation, apoptosis, protein synthesis, and metabolism. The PI3K pathway can be acti... Immunogenic Tumor Cell Death for Optimal Anticancer Therapy: The Calreticulin Exposure Pathway [作者：Zitvogel, L; Kepp, O; Senovilla, L; Menger, L; Chaput, N; Kroemer, G,期刊：Clinical Cancer Research, 页码：3100-3104 , 文章类型： Article，,卷期：2010年16-12] In response to some chemotherapeutic agents such as anthracyclines and oxaliplatin, cancer cells undergo immunogenic apoptosis, meaning that their corpses are engulfed by dendritic cells and that tumor cell antigens are ... Controversies in Cancer Stem Cells: Targeting Embryonic Signaling Pathways [作者：Takebe, N; Ivy, SP,期刊：Clinical Cancer Research, 页码：3106-3112 , 文章类型： Article，,卷期：2010年16-12] Selectively targeting cancer stem cells (CSC) or tumor-initiating cells (TIC; from this point onward referred to as CSCs) with novel agents is a rapidly emerging field of oncology. Our knowledge of CSCs and their niche m... Cancer Stem Cells and Self-renewal [作者：O'Brien, CA; Kreso, A; Jamieson, CHM,期刊：Clinical Cancer Research, 页码：3113-3120 , 文章类型： Article，,卷期：2010年16-12] The cancer stem cell (CSC) or cancer-initiating cancer (C-IC) model has garnered considerable attention over the past several years since Dick and colleagues published a seminal report showing that a hierarchy exists amo... The Difficulty of Targeting Cancer Stem Cell Niches [作者：LaBarge, MA,期刊：Clinical Cancer Research, 页码：3121-3129 , 文章类型： Article，,卷期：2010年16-12] Normal stem cell niches typically are identified by their distinctive anatomical features and by association with tissue-specific stem cells. Identifying cancer stem cell ( CSC) niches presents a special problem because ... Targeting Hedgehog - a Cancer Stem Cell Pathway [作者：Merchant, AA; Matsui, W,期刊：Clinical Cancer Research, 页码：3130-3140 , 文章类型： Article，,卷期：2010年16-12] The Hedgehog ( Hh) pathway has been implicated in a wide variety of human tumors, and early clinical trials with pathway antagonists have validated Hh signaling as a bona fide anticancer target. Despite these encouraging... Targeting Notch to Target Cancer Stem Cells [作者：Pannuti, A; Foreman, K; Rizzo, P; Osipo, C; Golde, T; Osborne, B; Miele, L,期刊：Clinical Cancer Research, 页码：3141-3152 , 文章类型： Article，,卷期：2010年16-12] The cellular heterogeneity of neoplasms has been at the center of considerable interest since the "cancer stem cell hypothesis", originally formulated for hematologic malignancies, was extended to solid tumors. The origi... Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells? [作者：Takahashi-Yanaga, F; Kahn, M,期刊：Clinical Cancer Research, 页码：3153-3162 , 文章类型： Article，,卷期：2010年16-12] The Wnt signaling pathways have been conserved throughout evolution and regulate cell proliferation, morphology, motility, and fate during embryonic development. These pathways also play important roles throughout adult ... Molecular Diagnosis of Activating EGFR Mutations in Non-Small Cell Lung Cancer Using Mutation-Specific Antibodies for Immunohistochemical Analysis [作者：Kawahara, A; Yamamoto, C; Nakashima, K; Azuma, K; Hattori, S; Kashihara, M; Aizawa, H; Basaki, Y; Kuwano, M; Kage, M; Mitsudomi, T; Ono, M,期刊：Clinical Cancer Research, 页码：3163-3170 , 文章类型： Article，,卷期：2010年16-12] Purpose: Therapeutic responses of non-small cell lung carcinoma (NSCLC) to epidermal growth factor receptor (EGFR)-targeted drugs, such as gefitinib and erlotinib, are closely associated with activating EGFR mutations. T... Aurora Kinase A Promotes Ovarian Tumorigenesis through Dysregulation of the Cell Cycle and Suppression of BRCA2 [作者：Yang, G; Chang, B; Yang, F; Guo, XQ; Cai, KQ; Xiao, X; Wang, HM; Sen, S; Hung, MC; Mills, GB; Chang, S; Multani, AS; Mercado-Uribe, I; Liu, JS,期刊：Clinical Cancer Research, 页码：3171-3181 , 文章类型： Article，,卷期：2010年16-12] Purpose: Aurora kinase A ( Aurora-A) is known to regulate genomic instability and tumorigenesis in multiple human cancers. The underlying mechanism, however, is not fully understood. We examined the molecular mechanism o... FTY720 Shows Promising In vitro and In vivo Preclinical Activity by Downmodulating Cyclin D1 and Phospho-Akt in Mantle Cell Lymphoma [作者：Liu, Q; Alinari, L; Chen, CS; Yan, FT; Dalton, JT; Lapalombella, R; Zhang, XL; Mani, R; Lin, T; Byrd, JC; Baiocchi, RA; Muthusamy, N,期刊：Clinical Cancer Research, 页码：3182-3192 , 文章类型： Article，,卷期：2010年16-12] Purpose: Despite the progress that has been made in the treatment of mantle cell lymphoma (MCL), all patients invariably relapse with the currently available therapies. Because of the absence of curative therapy for MCL,... Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development [作者：Pitts, TM; Tan, AC; Kulikowski, GN; Tentler, JJ; Brown, AM; Flanigan, SA; Leong, S; Coldren, CD; Hirsch, FR; Varella-Garcia, M; Korch, C; Eckhardt, SG,期刊：Clinical Cancer Research, 页码：3193-3204 , 文章类型： Article，,卷期：2010年16-12] Background: A plethora of agents is in early stages of development for colorectal cancer (CRC), including those that target the insulin-like growth factor I receptor (IGFIR) pathway. In the current environment of numerou... Molecular Imaging of N-linked Glycosylation Suggests Glycan Biosynthesis Is a Novel Target for Cancer Therapy [作者：Contessa, JN; Bhojani, MS; Freeze, HH; Ross, BD; Rehemtulla, A; Lawrence, TS,期刊：Clinical Cancer Research, 页码：3205-3214 , 文章类型： Article，,卷期：2010年16-12] Purpose: Redundant receptor tyrosine kinase (RTK) signaling is a mechanism for therapeutic resistance to epidermal growth factor receptor (EGFR) inhibition. A strategy to reduce parallel signaling by coexpressed RTKs ... Drug-Induced Vessel Remodeling in Bone Metastases as Assessed by Dynamic Contrast Enhanced Magnetic Resonance Imaging and Vessel Size Imaging: A Longitudinal In vivo Study [作者：Bauerle, T; Merz, M; Komljenovic, D; Zwick, S; Semmler, W,期刊：Clinical Cancer Research, 页码：3215-3225 , 文章类型： Article，,卷期：2010年16-12] Purpose: The aim of this study was to assess the antiangiogenic treatment effects of zoledronic acid (ZA) and sunitinib malate (SM) noninvasively in experimental breast cancer bone metastases by dynamic contrast-enhanced...