- Role of Type 1 IFNs in Antiglioma Immunosurveillance-Using Mouse Studies to Guide Examination of Novel Prognostic Markers in Humans
[作者:Fujita, M; Scheurer, ME; Decker, SA; McDonald, HA; Kohanbash, G; Kastenhuber, ER; Kato, H; Bondy, ML; Ohlfest, JR; Okada, H,期刊:Clinical Cancer Research, 页码:3409-3419 , 文章类型: Article,,卷期:2010年16-13]
- Purpose: We hypothesized that the type 1 IFNs would play a pivotal role in antiglioma immunosurveillance through promotion of type 1 adaptive immunity and suppression of immunoregulatory cells.Experimental Design: We ind...
- Depletion of Tumor-Associated Macrophages Enhances the Effect of Sorafenib in Metastatic Liver Cancer Models by Antimetastatic and Antiangiogenic Effects
[作者:Zhang, W; Zhu, XD; Sun, HC; Xiong, YQ; Zhuang, PY; Xu, HX; Kong, LQ; Wang, L; Wu, WZ; Tang, ZY,期刊:Clinical Cancer Research, 页码:3420-3430 , 文章类型: Article,,卷期:2010年16-13]
- Purpose: To investigate the role of macrophages in tumor progression under sorafenib treatment and to explore whether combination of drugs that deplete macrophages improved the antitumor effect of sorafenib.Experimental ...
- Rapid and Robust Transgenic High-Grade Glioma Mouse Models for Therapy Intervention Studies
[作者:de Vries, NA; Bruggeman, SW; Hulsman, D; de Vries, HI; Zevenhoven, J; Buckle, T; Hamans, BC; Leenders, WP; Beijnen, JH; van Lohuizen, M; Berns, AJM; van Tellingen, O,期刊:Clinical Cancer Research, 页码:3431-3441 , 文章类型: Article,,卷期:2010年16-13]
- Purpose: To develop a transgenic mouse model of glioma that can be conveniently used for testing therapy intervention strategies. High-grade glioma is a devastating and uniformly fatal disease for which better therapy is...
- Prognostic Significance of TRAIL Signaling Molecules in Stage II and III Colorectal Cancer
[作者:McLornan, DP; Barrett, HL; Cummins, R; McDermott, U; McDowell, C; Conlon, SJ; Coyle, VM; Van Schaeybroeck, S; Wilson, R; Kay, EW; Longley, DB; Johnston, PG,期刊:Clinical Cancer Research, 页码:3442-3451 , 文章类型: Article,,卷期:2010年16-13]
- Purpose: We previously found that cellular FLICE-inhibitory protein (c-FLIP), caspase 8, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor 2 (DR5) are major regulators of cell viability and che...
- Development of a Multiplexed Tumor-Associated Autoantibody-Based Blood Test for the Detection of Non-Small Cell Lung Cancer
[作者:Farlow, EC; Patel, K; Basu, S; Lee, BS; Kim, AW; Coon, JS; Faber, LP; Bonomi, P; Liptay, MJ; Borgia, JA,期刊:Clinical Cancer Research, 页码:3452-3462 , 文章类型: Article,,卷期:2010年16-13]
- Purpose: Non-small cell lung cancer (NSCLC) has an overall 5-year survival of <15%; however, the 5-year survival for stage I disease is over 50%. Unfortunately, 75% of NSCLC is diagnosed at an advanced stage not amenable...
- Molecular Analysis of Plasma DNA for the Early Detection of Lung Cancer by Quantitative Methylation-Specific PCR
[作者:Ostrow, KL; Hoque, MO; Loyo, M; Brait, M; Greenberg, A; Siegfried, JM; Grandis, JR; Davis, AG; Bigbee, WL; Rom, W; Sidransky, D,期刊:Clinical Cancer Research, 页码:3463-3472 , 文章类型: Article,,卷期:2010年16-13]
- Purpose: Aberrant promoter hypermethylation of tumor suppressor genes is a promising marker for lung cancer detection. We investigated the likelihood of detecting aberrant DNA methylation of tumor suppressor genes in pla...
- DNA Cytometry Testing for Cervical Cancer Screening - Response
[作者:Tong, H; Shen, R; Kan, YJ; Wang, ZM; Wang, YQ; Li, FS; Wang, FZ; Yang, J; Wang, F; Guo, XR,期刊:Clinical Cancer Research, 页码:U39-3519 , 文章类型: Letter,,卷期:2010年16-13]
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- Diverse Associations between ESR1 Polymorphism and Breast Cancer Development and Progression
[作者:Ding, SL; Yu, JC; Chen, ST; Hsu, GC; Hsu, HM; Ho, JY; Lin, YH; Chang, CC; Fann, CSJ; Cheng, CW; Wu, PE; Shen, CY,期刊:Clinical Cancer Research, 页码:3473-3484 , 文章类型: Article,,卷期:2010年16-13]
- Purpose: To test the hypothesis that polymorphisms of ESR1, the gene encoding estrogen receptor alpha (ER alpha), are associated with susceptibility, clinical phenotype, and progression of breast cancer.Patients and Meth...
- Tremelimumab in Combination with Exemestane in Patients with Advanced Breast Cancer and Treatment-Associated Modulation of Inducible Costimulator Expression on Patient T Cells
[作者:Vonderheide, RH; LoRusso, PM; Khalil, M; Gartner, EM; Khaira, D; Soulieres, D; Dorazio, P; Trosko, JA; Ruter, J; Mariani, GL; Usari, T; Domchek, SM,期刊:Clinical Cancer Research, 页码:3485-3494 , 文章类型: Article,,卷期:2010年16-13]
- Purpose: Tremelimumab is a fully human monoclonal antibody specific for CTL-associated antigen 4 (CTLA4) with single-agent activity in certain tumors but has not been evaluated in patients with breast cancer.Experimental...
- Results from a Phase I Clinical Study of the Novel Ii-Key/HER-2/neu(776-790) Hybrid Peptide Vaccine in Patients with Prostate Cancer
[作者:Perez, SA; Kallinteris, NL; Bisias, S; Tzonis, PK; Georgakopoulou, K; Varla-Leftherioti, M; Papamichail, M; Thanos, A; von Hofe, E; Baxevanis, CN,期刊:Clinical Cancer Research, 页码:3495-3506 , 文章类型: Article,,卷期:2010年16-13]
- Purpose: Active immunotherapy is emerging as a potential therapeutic approach for prostate cancer. We conducted the first phase I trial of an Ii-Key/HER-2/neu(776-790) hybrid peptide vaccine (AE37) with recombinant granu...
- A Phase I Study of Foretinib, a Multi-Targeted Inhibitor of c-Met and Vascular Endothelial Growth Factor Receptor 2
[作者:Eder, JP; Shapiro, GI; Appleman, LJ; Zhu, AX; Miles, D; Keer, H; Cancilla, B; Chu, F; Hitchcock-Bryan, S; Sherman, L; McCallum, S; Heath, EI; Boerner, SA; LoRusso, PM,期刊:Clinical Cancer Research, 页码:3507-3516 , 文章类型: Article,,卷期:2010年16-13]
- Purpose: Foretinib is an oral multikinase inhibitor targeting Met, RON, Axl, and vascular endothelial growth factor receptor. We conducted a phase I, first-time-in-human, clinical trial using escalating doses of oral for...
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