- The Efficacy of the Novel Dual PI3-Kinase/mTOR Inhibitor NVP-BEZ235 Compared with Rapamycin in Renal Cell Carcinoma
[作者:Cho, DC; Cohen, MB; Panka, DJ; Collins, M; Ghebremichael, M; Atkins, MB; Signoretti, S; Mier, JW,期刊:Clinical Cancer Research, 页码:3628-3638 , 文章类型: Article,,卷期:2010年16-14]
- Purpose: Inhibitors of TORC1 have been shown to be active in patients with metastatic renal cell carcinoma (RCC). As the phosphatidylinositol 3-kinase (PI3K) pathway activates numerous other kinases, transcription factor...
- Augmentation of Radiation Response by Motesanib, a Multikinase Inhibitor that Targets Vascular Endothelial Growth Factor Receptors
[作者:Kruser, TJ; Wheeler, DL; Armstrong, EA; Iida, M; Kozak, KR; van der Kogel, AJ; Bussink, J; Coxon, A; Polverino, A; Harari, PM,期刊:Clinical Cancer Research, 页码:3639-3647 , 文章类型: Article,,卷期:2010年16-14]
- Background: Motesanib is a potent inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3, platelet-derived growth factor receptor, and Kit receptors. In this report we examine the interaction betwe...
- Pralatrexate Is Synergistic with the Proteasome Inhibitor Bortezomib in In vitro and In vivo Models of T-Cell Lymphoid Malignancies
[作者:Marchi, E; Paoluzzi, L; Scotto, L; Seshan, VE; Zain, JM; Zinzani, PL; O'Connor, OA,期刊:Clinical Cancer Research, 页码:3648-3658 , 文章类型: Article,,卷期:2010年16-14]
- Purpose: Pralatrexate (10-propargyl-10-deazaaminopterin) is an antifolate with improved cellular uptake and retention due to greater affinity for the reduced folate carrier (RFC-1) and folyl-polyglutamyl synthase. Based ...
- Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3 ' Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical Models
[作者:O'Brien, C; Wallin, JJ; Sampath, D; GuhaThakurta, D; Savage, H; Punnoose, EA; Guan, J; Berry, L; Prior, WW; Amler, LC; Belvin, M; Friedman, LS; Lackner, MR,期刊:Clinical Cancer Research, 页码:3670-3683 , 文章类型: Article,,卷期:2010年16-14]
- Purpose: The class I phosphatidylinositol 3' kinase (PI3K) plays a major role in proliferation and survival in a wide variety of human cancers. A key factor in successful development of drugs targeting this pathway is li...
- Development of an Orthotopic Model of Invasive Pancreatic Cancer in an Immunocompetent Murine Host
[作者:Tseng, WW; Winer, D; Kenkel, JA; Choi, O; Shain, AH; Pollack, JR; French, R; Lowy, AM; Engleman, EG,期刊:Clinical Cancer Research, 页码:3684-3695 , 文章类型: Article,,卷期:2010年16-14]
- Purpose: The most common preclinical models of pancreatic adenocarcinoma utilize human cells or tissues that are xenografted into immunodeficient hosts. Several immunocompetent, genetically engineered mouse models of pan...
- Potent Antitumor Activity in Experimental Hepatocellular Carcinoma by Adenovirus-Mediated Coexpression of TRAIL and shRNA against COX-2
[作者:Chen, Q; Lou, WJ; Shen, JJ; Ma, LN; Yang, Z; Liu, L; Luo, JJ; Qian, C,期刊:Clinical Cancer Research, 页码:3696-3705 , 文章类型: Article,,卷期:2010年16-14]
- Purpose: Recent studies have indicated that short hairpin RNA (shRNA) driven by RNA polymerase (Pol) II promoters can be transcribed into precursor mRNAs together with transgenes. It remains unclear, however, whether coe...
- Prognostic Significance of Telomerase Polymorphism in Non-Small Cell Lung Cancer
[作者:Catarino, R; Araujo, A; Coelho, A; Gomes, M; Nogueira, A; Lopes, C; Medeiros, RM,期刊:Clinical Cancer Research, 页码:3706-3712 , 文章类型: Article,,卷期:2010年16-14]
- Purpose: Lung cancer is the leading cause of death in oncologic patients of western countries, with very low survival rates. Telomerase main components are the catalytic subunit (hTERT) and the RNA template (hTR). A func...
- Mature MicroRNA Sequence Polymorphism in MIR196A2 Is Associated with Risk and Prognosis of Head and Neck Cancer
[作者:Christensen, BC; Avissar-Whiting, M; Ouellet, LG; Butler, RA; Nelson, HH; McClean, MD; Marsit, CJ; Kelsey, KT,期刊:Clinical Cancer Research, 页码:3713-3720 , 文章类型: Article,,卷期:2010年16-14]
- Purpose: The central role of microRNAs as regulators of translation has been well established, whereas the relationships between genetic variation in microRNAs and disease risk is only beginning to be explored. A polymor...
- Dynamic Single-Cell Network Profiles in Acute Myelogenous Leukemia Are Associated with Patient Response to Standard Induction Therapy
[作者:Kornblau, SM; Minden, MD; Rosen, DB; Putta, S; Cohen, A; Covey, T; Spellmeyer, DC; Fantl, WJ; Gayko, U; Cesano, A,期刊:Clinical Cancer Research, 页码:3721-3733 , 文章类型: Article,,卷期:2010年16-14]
- Purpose: Complete response to induction chemotherapy is observed in similar to 60% of patients with newly diagnosed non-M3 acute myelogenous leukemia (AML). However, no methods exist to predict with high accuracy at the ...
- High Levels of Nucleolar Expression of Nucleolin Are Associated with Better Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma
[作者:Peng, L; Liang, J; Wang, H; Song, XZ; Rashid, A; Gomez, HF; Corley, LJ; Abbruzzese, JL; Fleming, JB; Evans, DB; Wang, HM,期刊:Clinical Cancer Research, 页码:3734-3742 , 文章类型: Article,,卷期:2010年16-14]
- Purpose: Nucleolin is a major nucleolar protein that has been shown to be overexpressed in rapidly dividing cells and plays an essential role in cell proliferation and survival. However, the expression and significance o...
- Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features
[作者:Solis, LM; Behrens, C; Dong, WL; Suraokar, M; Ozburn, NC; Moran, CA; Corvalan, AH; Biswal, S; Swisher, SG; Bekele, BN; Minna, JD; Stewart, DJ; Wistuba, II,期刊:Clinical Cancer Research, 页码:3743-3753 , 文章类型: Article,,卷期:2010年16-14]
- Purpose: To understand the role of nuclear factor erythroid-2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) in non-small cell lung cancer (NSCLC), we studied their expression in a large series o...
- Ten Common Genetic Variants Associated with Colorectal Cancer Risk Are Not Associated with Survival after Diagnosis
[作者:Tenesa, A; Theodoratou, E; Din, FVN; Farrington, SM; Cetnarskyj, R; Barnetson, RA; Porteous, ME; Campbell, H; Dunlop, MG,期刊:Clinical Cancer Research, 页码:3754-3759 , 文章类型: Article,,卷期:2010年16-14]
- Purpose: To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival.Experimental Desi...
- Development of Autoantibody Signatures as Novel Diagnostic Biomarkers of Non-Small Cell Lung Cancer
[作者:Wu, LL; Chang, WJ; Zhao, JF; Yu, YW; Tan, XJ; Su, T; Zhao, LJ; Huang, SD; Liu, SY; Cao, GW,期刊:Clinical Cancer Research, 页码:3760-3768 , 文章类型: Article,,卷期:2010年16-14]
- Purpose: To select autoantibody signatures as noninvasive biomarkers of non-small cell lung cancer (NSCLC).Experimental Design: A phage cDNA expression library was constructed with fresh samples from 30 lung cancer patie...
- Intercohort Gene Expression Co-Analysis Reveals Chemokine Receptors as Prognostic Indicators in Ewing's Sarcoma
[作者:Bennani-Baiti, IM; Cooper, A; Lawlor, ER; Kauer, M; Ban, J; Aryee, DNT; Kovar, H,期刊:Clinical Cancer Research, 页码:3769-3778 , 文章类型: Article,,卷期:2010年16-14]
- Purpose: We report a novel analytic method, named intercohort co-analysis or Ican, which aids in the discovery of genes with predictive value for the progression or outcome of diseases from small-size cohorts. We tested ...
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