- Accumulation of Foxp3(+) T Regulatory Cells in Draining Lymph Nodes Correlates with Disease Progression and Immune Suppression in Colorectal Cancer Patients
[作者：Deng, LF; Zhang, HZ; Luan, Y; Zhang, JF; Xing, QA; Dong, SX; Wu, XR; Liu, MY; Wang, SD,期刊：Clinical Cancer Research, 页码：4105-4112 , 文章类型： Article，,卷期：2010年16-16]
- Purpose: To assess the relation of Foxp3(+) regulatory T cells (Treg) in tumor draining lymph nodes (TDLNs) with tumor progression and immune suppression in colorectal cancer (CRC).Experimental Design: Flow cytometry was...
- The Oncoprotein SF2/ASF Promotes Non-Small Cell Lung Cancer Survival by Enhancing Survivin Expression
[作者：Ezponda, T; Pajares, MJ; Agorreta, J; Echeveste, JI; Lopez-Picazo, JM; Torre, W; Pio, R; Montuenga, LM,期刊：Clinical Cancer Research, 页码：4113-4125 , 文章类型： Article，,卷期：2010年16-16]
- Purpose: SF2/ASF is a splicing factor recently described as an oncoprotein. In the present work, we examined the role of SF2/ASF in human non-small cell lung cancer (NSCLC) and analyzed the molecular mechanisms involved ...
- SMAD4 Immunohistochemistry Reflects Genetic Status in Juvenile Polyposis Syndrome
[作者：Langeveld, D; van Hattem, WA; de Leng, WWJ; Morsink, FH; ten Kate, FJW; Giardiello, FM; Offerhaus, GJA; Brosens, LAA,期刊：Clinical Cancer Research, 页码：4126-4134 , 文章类型： Article，,卷期：2010年16-16]
- Purpose: Juvenile polyposis syndrome (JPS) can be caused by a germline defect of the SMAD4 gene. Somatic inactivation of SMAD4 occurs in pancreatic and colorectal cancers and is reflected by loss of SMAD4 immunohistochem...
- NF1 Inactivation in Adult Acute Myelogenous Leukemia
[作者：Parkin, B; Ouillette, P; Wang, Y; Liu, Y; Wright, W; Roulston, D; Purkayastha, A; Dressel, A; Karp, J; Bockenstedt, P; Al-Zoubi, A; Talpaz, M; Kujawski, L; Liu, Y; Shedden, K; Shakhan, S; Li, C; Erba, H; Malek, SN,期刊：Clinical Cancer Research, 页码：4135-4147 , 文章类型： Article，,卷期：2010年16-16]
- Purpose: This study was conducted to identify novel genes with importance to the biology of adult acute myelogenous leukemia (AML).Experimental Design: We analyzed DNA from highly purified AML blasts and paired buccal ce...
- Mutation of SDHB is a Cause of Hypoxia-Related High-Altitude Paraganglioma
[作者：Cerecer-Gil, NY; Figuera, LE; Llamas, FJ; Lara, M; Escamilla, JG; Ramos, R; Estrada, G; Hussain, AK; Gaal, J; Korpershoek, E; de Krijger, RR; Dinjens, WNM; Devilee, P; Bayley, JP,期刊：Clinical Cancer Research, 页码：4148-4154 , 文章类型： Article，,卷期：2010年16-16]
- Purpose: Paragangliomas of the head and neck are neuroendocrine tumors and are associated with germ line mutations of the tricarboxylic acid cycle-related genes SDHB, SDHC, SDHD, and SDHAF2. Hypoxia is important in most ...
- Genomic Profiling Reveals Alternative Genetic Pathways of Meningioma Malignant Progression Dependent on the Underlying NF2 Status
[作者：Goutagny, S; Yang, HW; Zucman-Rossi, J; Chan, J; Dreyfuss, JM; Park, PJ; Black, PM; Giovannini, M; Carroll, RS; Kalamarides, M,期刊：Clinical Cancer Research, 页码：4155-4164 , 文章类型： Article，,卷期：2010年16-16]
- Purpose: Meningiomas are the most common central nervous system tumors in the population of age 35 and older. WHO defines three grades predictive of the risk of recurrence. Clinical data supporting histologic malignant p...
- Gene Array and Fluorescence In situ Hybridization Biomarkers of Activity of Saracatinib (AZD0530), a Src Inhibitor, in a Preclinical Model of Colorectal Cancer
[作者：Arcaroli, JJ; Touban, BM; Tan, AC; Varella-Garcia, M; Powell, RW; Eckhardt, SG; Elvin, P; Gao, DX; Messersmith, WA,期刊：Clinical Cancer Research, 页码：4165-4177 , 文章类型： Article，,卷期：2010年16-16]
- Purpose: To evaluate the efficacy of saracatinib (AZD0530), an oral Src inhibitor, in colorectal cancer (CRC) and to identify biomarkers that predict antitumor activity.Experimental Design: Twenty-three CRC cell lines we...
- Biological Evidence for Dual Antiangiogenic-Antiaromatase Activity of the VEGFR Inhibitor PTK787/ZK222584 In vivo
[作者：Banerjee, S; A'Hern, R; Detre, S; Littlewood-Evans, AJ; Evans, DB; Dowsett, M; Martin, LA,期刊：Clinical Cancer Research, 页码：4178-4187 , 文章类型： Article，,卷期：2010年16-16]
- Purpose: Targeting vascular endothelial growth factor (VEGF) and estrogen receptor signaling pathways concomitantly may enhance benefit in estrogen receptor-positive breast cancer. We had shown previously that the VEGF r...
- Influence of Oct1/Oct2-Deficiency on Cisplatin-Induced Changes in Urinary N-Acetyl-beta-D-Glucosaminidase
[作者：Franke, RM; Kosloske, AM; Lancaster, CS; Filipski, KK; Hu, CX; Zolk, O; Mathijssen, RH; Sparreboom, A,期刊：Clinical Cancer Research, 页码：4198-4206 , 文章类型： Article，,卷期：2010年16-16]
- Purpose: This study aimed to test the influence of functional renal organic cation transporters (OCT2 in humans, Oct1 and Oct2 in mice) on biomarkers of cisplatin nephrotoxicity, such as urinary activity of N-acetyl-beta...
- Inhibition of Hypoxia Inducible Factor-1 alpha by Dihydroxyphenylethanol, a Product from Olive Oil, Blocks Microsomal Prostaglandin-E Synthase-1/Vascular Endothelial Growth Factor Expression and Reduces Tumor Angiogenesis
[作者：Terzuoli, E; Donnini, S; Giachetti, A; Iniguez, MA; Fresno, M; Melillo, G; Ziche, M,期刊：Clinical Cancer Research, 页码：4207-4216 , 文章类型： Article，,卷期：2010年16-16]
- Purpose: 2-(3,4-dihydroxyphenil)-ethanol (DPE), a polyphenol present in olive oil, has been found to attenuate the growth of colon cancer cells, an effect presumably related to its anti-inflammatory activity.Experimental...
- Diminished Sensitivity of Chronic Lymphocytic Leukemia Cells to ABT-737 and ABT-263 Due to Albumin Binding in Blood
[作者：Vogler, M; Furdas, SD; Jung, M; Kuwana, T; Dyer, MJS; Cohen, GM,期刊：Clinical Cancer Research, 页码：4217-4225 , 文章类型： Article，,卷期：2010年16-16]
- Purpose: Inhibition of the antiapoptotic BCL2 family is one of the most promising areas of anticancer drug development. However, ABT-737, a specific BCL2 inhibitor, is neither orally bioavailable nor metabolically stable...
- Quantitation of p95HER2 in Paraffin Sections by Using a p95-Specific Antibody and Correlation with Outcome in a Cohort of Trastuzumab-Treated Breast Cancer Patients
[作者：Sperinde, J; Jin, XG; Banerjee, J; Penuel, E; Saha, A; Diedrich, G; Huang, WD; Leitzel, K; Weidler, J; Ali, SM; Fuchs, EM; Singer, CF; Kostler, WJ; Bates, M; Parry, G; Winslow, J; Lipton, A,期刊：Clinical Cancer Research, 页码：4226-4235 , 文章类型： Article，,卷期：2010年16-16]
- Purpose: p95HER2 is an NH2-terminally truncated form of HER2 that lacks the trastuzumab binding site and is therefore thought to confer resistance to trastuzumab treatment. In this report, we introduce a new antibody tha...
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