- Synthesis and antitumor activity of new shikonin glycosides
[作者:Su, YH; Xie, JS; Wang, YG; Hu, X; Lin, XF,期刊:European Journal of Medicinal Chemistry, 页码:2713-2718 , 文章类型: Article,,卷期:2010年45-7]
- Eleven shikonin glycosides were synthesized and evaluated for their antitumor activity in vitro. Some of them were found to exhibit cytotoxic activities against both drug sensitive cell lines (K562, MCF-7 and HL60) and t...
- A note to the biological activity of benzoxazine derivatives containing the thioxo group
[作者:Waisser, K; Petrlikova, E; Perina, M; Klimesova, V; Kunes, J; Palat, K; Kaustova, J; Dahse, HM; Mollmann, U,期刊:European Journal of Medicinal Chemistry, 页码:2719-2725 , 文章类型: Article,,卷期:2010年45-7]
- New 3-benzyl-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and 3-benzyl-2H-1,3-benzoxazine-2,4(3H)-dithiones were synthesized. The compounds were tested for in vitro antimycobacterial activity against Mycobacterium tuberculosis...
- Trifluoromethyl-promoted homocamptothecins: Synthesis and biological activity
[作者:Zhu, LJ; Miao, ZY; Sheng, CQ; Guo, W; Yao, JZ; Liu, WF; Che, XY; Wang, WY; Cheng, PF; Zhang, WN,期刊:European Journal of Medicinal Chemistry, 页码:2726-2732 , 文章类型: Article,,卷期:2010年45-7]
- The homocamptothecin (hCPT) represents a new class of topoisomerase inhibitor which combines enhanced plasma stability and strong antitumor activity. Fluorine imparts desirable characteristics to drugs by modulating both...
- Evaluation of labdane derivatives as potential anti-inflammatory agents
[作者:Giron, N; Perez-Sacau, E; Lopez-Fontal, R; Amaro-Luis, JM; Hortelano, S; Estevez-Braun, A; de las Heras, B,期刊:European Journal of Medicinal Chemistry, 页码:3155-3161 , 文章类型: Article,,卷期:2010年45-7]
- In the present study, a series of labdane derivatives (2-9) were prepared from labdanediol (1) and their potential as anti-inflammatory agents were evaluated on lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. All...
- Mn(II), Co(II) and Zn(II) complexes with heterocyclic substituted thiosemicarbazones: Synthesis, characterization, X-ray crystal structures and antitumor comparison
[作者:Li, MX; Chen, CL; Zhang, D; Niu, JY; Ji, BS,期刊:European Journal of Medicinal Chemistry, 页码:3169-3177 , 文章类型: Article,,卷期:2010年45-7]
- Transition metal complexes Mn(L-1)(2) (1), Mn(L-2)(2) (2), Co(L-3)(2)Cl 4H(2)O (3), Zn(L-3)(2) DMF (4), Co(HL4)(2)(ClO4)(2) 3H(2)O (5) and Zn(L-5)(2) DMF (6) where HL1 = 2-acetylpyridine thiosemicarbazone, HL2 = 2-acetyl...
- Metal based biologically active compounds: Design, synthesis, and antibacterial/antifungal/cytotoxic properties of triazole-derived Schiff bases and their oxovanadium(IV) complexes
[作者:Chohan, ZH; Sumrra, SH; Youssoufi, MH; Hadda, TB,期刊:European Journal of Medicinal Chemistry, 页码:2739-2747 , 文章类型: Article,,卷期:2010年45-7]
- A new series of oxovanadium(IV) complexes have been designed and synthesized with a new class of triazole Schiff bases derived from the reaction of 3,5-diamino-1,2,4-triazole with 2-hydroxy-1-naphthaldehyde, pyrrole-2-ca...
- 5-Isopropylidene-3-ethyl rhodanine induce growth inhibition followed by apoptosis in leukemia cells
[作者:Ravi, S; Chiruvella, KK; Rajesh, K; Prabhu, V; Raghavan, SC,期刊:European Journal of Medicinal Chemistry, 页码:2748-2752 , 文章类型: Article,,卷期:2010年45-7]
- 5-Isopropylidene-3-ethyl rhodanine II was prepared by conventional and Microwave assisted synthesis. For the first time, we found that rhodanine II treatment led to cytotoxicity in leukemic cell line, CEM by inducing apo...
- New quinoxaline 1, 4-di-N-oxides: Anticancer and hypoxia-selective therapeutic agents
[作者:Ismail, MMF; Amin, KM; Noaman, E; Soliman, DH; Ammar, YA,期刊:European Journal of Medicinal Chemistry, 页码:2733-2738 , 文章类型: Article,,卷期:2010年45-7]
- A new series of quinoxaline 1,4-di-N-oxides was synthesized and evaluated for antitumor and hypoxic-selective cytotoxic activities. Antitumor activity against liver carcinoma (Hepg2) and brain tumor (U251) human cell lin...
- Synthesis and antiproliferative activity of indolizine derivatives incorporating a cyclopropylcarbonyl group against Hep-G(2) cancer cell line
[作者:Shen, YM; Lv, PC; Chen, W; Liu, PG; Zhang, MZ; Zhu, HL,期刊:European Journal of Medicinal Chemistry, 页码:3184-3190 , 文章类型: Article,,卷期:2010年45-7]
- Indolizine and annulated indolizine derivatives incorporating a cyclopropylcarbonyl group were synthesized in a one pot procedure by the tanden reactions of [3 + 2] cycloaddition of the corresponding N-ylide with electro...
- New 6-amino-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-ones: Synthesis, characterization and antibacterial activity evaluation
[作者:Almajan, GL; Barbuceanu, SF; Saramet, I; Draghici, C,期刊:European Journal of Medicinal Chemistry, 页码:3191-3195 , 文章类型: Article,,卷期:2010年45-7]
- (4-X-Phenylsulfonyl)phenyl] containing 6-amino-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-ones were synthesized by intermolecular condensation of 2-chloro-N-phenylacetamide, 2...
- Synthesis, structures, and urease inhibitory activities of three copper(II) and zinc(II) complexes with 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol
[作者:You, ZL; Ni, LL; Shi, DH; Bai, S,期刊:European Journal of Medicinal Chemistry, 页码:3196-3199 , 文章类型: Article,,卷期:2010年45-7]
- In order to explore novel urease inhibitors, three new mononuclear complexes of Cu(II) and Zn(II) with Schiff base 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol have been prepared and structurally character...
- Cytotoxicity and Topo I targeting activity of substituted 10-nitrogenous heterocyclic aromatic group derivatives of SN-38
[作者:Li, QY; Deng, XQ; Zu, YG; Lv, HY; Su, L; Yao, LP; Zhang, Y; Li, L,期刊:European Journal of Medicinal Chemistry, 页码:3200-3206 , 文章类型: Article,,卷期:2010年45-7]
- A series of 10-position substituted nitrogenous heterocyclic aromatic group derivatives of SN-38 were prepared. Most of these compounds possessed lower cytotoxicities than CPT. Compound 13 revealed potent cytotoxicity si...
- Molecular modeling studies of Rho kinase inhibitors using molecular docking and 3D-QSAR analysis
[作者:Qin, J; Lei, BL; Xi, LL; Liu, HX; Yao, XJ,期刊:European Journal of Medicinal Chemistry, 页码:2768-2776 , 文章类型: Article,,卷期:2010年45-7]
- Rho kinase (ROCK) has become an attractive target for the treatment of many diseases such as hypertension, stroke and cancer. In this work, molecular docking and three-dimensional quantitative structure-activity relation...
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